Population pharmacokinetics of 25-hydroxyvitamin D in healthy young adults

Milovanovic, Olivera; Milovanović, Jasmina R.; Djukic, Aleksandar; Matović, Milovan; Lucic, Aleksandra Tomic; Glumbić, Nenad; Radovanović, Ana; Janković, Slobodan M.

doi:10.5414/cp202185

Cited by 9 publications

(6 citation statements)

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“…In our study 49.3% of the participants were smokers, 13.3% consumed more than 3 alcoholic drinks weekly and 29.3% more than 3 cups of coffee daily. However, our final PPK model did not recognize any of these three covariates as important elements in 25-hydroxy vitamin D clearance, an observation which is in accordance with the results of previous PPK analysis in a healthy, young population (10). The effects of caffeine consumption in amounts larger than 300mg/day on the serum level of 25-hydroxy vitamin D has been studied in a large number of epidemiological and experimental trials and the results provide a much clearer picture of this correlation.…”

Section: Discussionsupporting

confidence: 89%

Population Pharmacokinetics of 25-Hydroxy Vitamin D in Non-Elderly Postmenopausal Women

Djoković¹,

Lucic²,

Milovanovic³

et al. 2019

Acta Poloniae Pharmaceutica - Drug Research

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Vitamin D is one of the keys to bone health, and the serum levels of this vitamin are a major concern for postmenopausal women. The aims of this study were to develop a population pharmacokinetic (PPK) model for the clearance of 25-hydroxy vitamin D in non-elderly postmenopausal women and to identify the factors which have a significant influence on its clearance. The study population consisted of postmenopausal women who had been referred for evaluation of bone mineral density (BMD) by DEXA (dual-energy x-ray absorptiometry) scanner. The population pharmacokinetics modeling was conducted using the ADVAN 1 subroutine from a non-linear mixed effects (NONMEM) program, and thirty-two covariates were assessed. A total of 75 serum concentrations were obtained from the same number of postmenopausal women and used for PPK analysis. The mean value of the participantsí age was 57.92 ± 3.93 years and their body weight was 69.76 ± 11.49 kg. A wide range of 25-hydroxy vitamin D concentrations was observed (from 3.41 to 61.92 ng/mL) with a mean value of 26.19 ± 10.95 ng/mL. A total of 32 covariates were examined and preliminary results suggested the influence of six covariates on 25-hydroxy vitamin D clearance. In the final PPK model, however, only one covariate was shown to have a significant impact on the clearance value ñ the mean daily dietary intake dose of vitamin D (DD). These findings offer a preliminary basis on which to determine the level of vitamin D supplementation required by individual postmenopausal women. It could prove particularly important in achieving optimal serum levels of vitamin D in this vulnerable population.

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Section: Discussionsupporting

confidence: 89%

Population Pharmacokinetics of 25-Hydroxy Vitamin D in Non-Elderly Postmenopausal Women

Djoković¹,

Lucic²,

Milovanovic³

et al. 2019

Acta Poloniae Pharmaceutica - Drug Research

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“…The semi-structured questionnaire designed for assessment of vitamin D status was based on previous studies concerning the topic and conducted in the same geographical area (26,27). That original questionnaire was modified and supplemented for additional variables of interest, taking into account the following: a) the questionnaires for assessment of demographic, socio-economic, nutritional and life-style habits of the country's population, used by the national public health authority (28); b) the guidelines for the assessment of status, protective and risk factors for bone and vitamin D metabolism (29,30); and c) general methodological principles (31).…”

Section: Methodsmentioning

confidence: 99%

Vitamin D Deficiency and Associated Factors in Patients with Mental Disorders Treated in Routine Practice

Ristic

Živanović

Milovanovic

et al. 2017

J Nutr Sci Vitaminol

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SummaryThis research aimed to investigate factors associated with vitamin D deficiency and to provide data about its prevalence in patients suffering from different psychiatric illnesses. The study had a cross-sectional design and it included 220 patients of both genders, aged from 19-81 y, with a wide range of mental disorders (F00-F89), and treated in routine ambulatory and hospital practice. The researchers collected data from three sources: medical records, a study questionnaire and biochemical analysis of patients' serum samples (concentration of vitamin D measured as 25(OH)D, calcium, phosphorus, magnesium, sodium and potassium). Data were analyzed using descriptive statistics, methods for hypothesis testing and binary logistic regression, at the p#0.05 level. A total of 140 patients (64%) had a deficiency of vitamin D (,12 ng/mL), and 45 (20%) had inadequate vitamin D serum levels (12-20 ng/mL), while 35 (16%) had sufficient vitamin D serum concentrations (.20 ng/mL). Among variables related to demographics, life style habits, mental illness, comorbid disorders and drugs, two of them, female gender (odds ratio (OR)52.5, 95% confidence interval (CI)51.3-4.9, p50.006) and using clozapine (OR515.6, 95% CI 1.7-144.7, p50.02), were significantly associated with vitamin D deficiency. Physical activity (OR5 0.4, p50.02), exercising (OR50.2, 95% CI , p50.02) and offal in the diet (OR50.5, 95% CI 0.3-0.9, p50.03) significantly aggregated in the patients who had a 25(OH)D serum concentration above the deficiency cut-off level. Patients with mental disorders are at high risk for vitamin D deficiency, particularly females and clozapine users as well as those having no adequate physical activity or dietary habits.

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“…According to our knowledge, there were no studies published in recent years which investigated 25(OH)D serum concentrations in our country in order to reveal the current vitamin D status for healthy people in a large sample. Yet, some studies which included the postmenopausal women and the students, measuring 25(OH)D serum concentrations during sunshine months, also found a very high frequency of vitamin D deficiency in those, apparently healthy subjects (15,16). Nevertheless, we are unable to make any conclusion about vitamin D status on the population level at present as the matter was outside the scope of our research.…”

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confidence: 67%

“…The semi-structured questionnaire for the assessment of vitamin D status was designed based on the previous studies in the field and the study was conducted within the same geographical area (7)(8). Other data were extracted from the patientsí medical files or were obtained through an interview in case of healthy subjects.…”

mentioning

confidence: 99%

Antipsychotics and Low Vitamin D – Additional Data Calling for Drug Causality Assessment

Ristic¹,

Мilоvаnоvić²,

Janjić³

et al. 2019

Acta Poloniae Pharmaceutica - Drug Research

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Population pharmacokinetics of 25-hydroxyvitamin D in healthy young adults

Abstract: The PPK model obtained determined clearance of 25-hydroxyvitamin D in a healthy young adult population in Serbia. Mean intake of vitamin D from foods and serum phosphate level are the most important covariates that influence value of 25-hydroxyvitamin D clearance in healthy young adults.

Cited by 9 publications

References 0 publications

Population Pharmacokinetics of 25-Hydroxy Vitamin D in Non-Elderly Postmenopausal Women

Population Pharmacokinetics of 25-Hydroxy Vitamin D in Non-Elderly Postmenopausal Women

Vitamin D Deficiency and Associated Factors in Patients with Mental Disorders Treated in Routine Practice

Antipsychotics and Low Vitamin D – Additional Data Calling for Drug Causality Assessment

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