Population Pharmacokinetics and Limited Sampling Strategy of Mycophenolate Mofetil for Indian Patients With Lupus Nephritis
Kévin Koloskoff,
Ritika Panwar,
Manish Rathi
et al.
Abstract:Background:
Mycophenolic acid is widely used to treat lupus nephritis (LN). However, it exhibits complex pharmacokinetics with large interindividual variability. This study aimed to develop a population pharmacokinetic (popPK) model and a 3-sample limited sampling strategy (LSS) to optimize therapeutic drug monitoring in Indian patients with LN.
Methods:
Five blood samples from each LN patient treated with mycophenolic acid were collected at steady-stat… Show more
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