Population pharmacokinetics and dosing optimization of perampanel in children with epilepsy: A real‐world study
Sichan Li,
Jiaqin Yi,
YaLi Tuo
et al.
Abstract:ObjectiveThe purposes of this study were to explore the pharmacokinetics of perampanel (PER) in children with epilepsy, identify factors that contribute to pharmacokinetic variations among subjects, evaluate the connection between PER exposure and clinical outcome, and establish an evidence‐based approach for tailoring individualized antiepileptic treatment in this specific population.MethodsIn this prospective study, PER plasma concentrations and genetic information on metabolic enzymes were obtained from 194… Show more
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