Population Pharmacodynamics of Midazolam Administered by Target Controlled Infusion in SICU Patients after CABG Surgery

Somma, Jacques; Donner, A.; Zomorodi, Katayoun; Sladen, Robert N.; Ramsay, James G.; Geller, Eran; Shafer, Steven L.

doi:10.1097/00000542-199812000-00021

Cited by 62 publications

(43 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To describe the possible time course of pain in absence of T, the concept of the Bvirtual drug^applied to the pharmacodynamics of midazolam in intensive care patients recovering from coronary artery bypass grafting was used (36). The Bvirtual drug^was assumed to be (i) absent at the time of skin closure with a non-linear increase with time (resembling the wane of post-surgical pain) or (ii) present in its highest concentration at the time of skin closure with a decline over time (residual anesthetic effects).…”

Section: Discussionmentioning

confidence: 99%

Population Pharmacokinetic/Pharmacodynamic Modelling of the Analgesic Effects of Tramadol in Pediatrics

et al. 2006

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Population Pharmacokinetic/Pharmacodynamic Modelling of the Analgesic Effects of Tramadol in Pediatrics

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Difficult to isolate such causal variables in patients with multiple comorbidities [62][63][64][65][66][67].…”

Section: Pathogenic Mechanismmentioning

confidence: 99%

“…By contrast, there is frequently a better quantitative relationship between a drug's plasma concentration and its effects. In healthy volunteers and critically ill patients, a relationship exists between levels of sedation induced by short-term midazolam and morphine infusions and their plasma concentrations [65][66][67]. Accordingly, understanding of the association between drug exposure and LTCI may be enhanced by further examination of plasma levels of psychoactive drugs to which the patient is exposed.…”

Section: Sedatives and Analgesicsmentioning

confidence: 99%

Pathophysiology of Delirium in the Intensive Care Unit

Gunther

Morandi

Ely

2008

Critical Care Clinics

153

101

View full text Add to dashboard Cite

“…The model, which has been described in a previous publication, 19 is based on the probability of observing a given lung deflation score at a given time according to the following relationship:…”

Section: Appendixmentioning

confidence: 99%

Bronchial blocker versus left double-lumen endotracheal tube in video-assisted thoracoscopic surgery: a randomized-controlled trial examining time and quality of lung deflation

Bussières

Somma

Castillo

et al. 2016

Can J Anesth/J Can Anesth

Self Cite

View full text Add to dashboard Cite

Bronchial blocker versus left double-lumen endotracheal tube in video-assisted thoracoscopic surgery: a randomized-controlled trial examining time and quality of lung deflation Comparaison du bloqueur bronchique à la sonde endotrachéale à double lumière gauche en chirurgie thoracoscopique vidéoassistée: une étude randomisée contrôlée examinant le temps et la qualité de l'affaissement du poumon Abstract Introduction Double-lumen endotracheal tubes (DL-ETT) and bronchial blockers (BB) have both been used for lung isolation in video-assisted thoracic surgery (VATS). Though not well studied, it is widely thought that a DL-ETT provides faster and better quality lung collapse. The aim of this study was to compare a BB technique vs a leftsided DL-ETT strategy with regard to the time and quality of lung collapse during one-lung ventilation (OLV) for elective VATS. Methods Forty patients requiring OLV for VATS were randomized to receive a BB (n = 20) or a left-sided DL-ETT (n = 20). The primary endpoint was the time from pleural opening (performed by the surgeon) until complete lung collapse. The time was evaluated offline by reviewing video recorded during the VATS. The quality of lung deflation was also graded offline using a visual scale (1 = no lung collapse; 2 = partial lung collapse; and 3 = total lung collapse) and was recorded at several time points after pleural incision. The surgeon also graded the time to complete lung collapse and quality of lung deflation during the procedure. The surgeon's guess as to which device was used for lung isolation was also recorded. Results Of the 40 patients enrolled in the study, 20 patients in the DL-ETT group and 18 in the BB group were analyzed. There mean (standard deviation) time to complete lung collapse of the operative lung was significantly faster using the BB compared with using the DL-ETT [7.5 (3.8) min vs 36.6 (29.1) min, respectively; mean difference, 29.1 min; 95% confidence interval, 1.8 to 7.2; P\0.001]. Overall, a higher proportion of patients in the BB group than in the DL-ETT group achieved a quality of lung collapse score of 3 at five minutes (57% vs 6%, respectively; P \ 0.004), ten minutes (73% vs 14%, respectively; P = 0.005), and 20 min (100% vs 25%, respectively; P = 0.002) after opening the pleura. The surgeon incorrectly guessed the type of device used in 78% of the BB group and 50% of the DL-ETT group (P = 0.10). Conclusion The time and quality of lung collapse during OLV for VATS was significantly better when using a BB than when using a left-sided DL-ETT. Surgeons could not reliably determine which device was being used based on the time and quality of lung collapse. This trial was registered at ClinicalTrials.gov number, NCT01615263. RésuméIntroduction Les sondes endotrachéales à double lumière (SET-DL) et les bloqueurs bronchiques (BB) ont tous deux été utilisés pour isoler un poumon pendant une chirurgie thoracique vidéo-assistée (CTVA). Bien que peu étudié, on pense communément qu'une SET-DL procure un affaissement du poumon plus rapide et de m...

show abstract

Population Pharmacodynamics of Midazolam Administered by Target Controlled Infusion in SICU Patients after CABG Surgery

Cited by 62 publications

References 29 publications

Population Pharmacokinetic/Pharmacodynamic Modelling of the Analgesic Effects of Tramadol in Pediatrics

Population Pharmacokinetic/Pharmacodynamic Modelling of the Analgesic Effects of Tramadol in Pediatrics

Pathophysiology of Delirium in the Intensive Care Unit

Bronchial blocker versus left double-lumen endotracheal tube in video-assisted thoracoscopic surgery: a randomized-controlled trial examining time and quality of lung deflation

Contact Info

Product

Resources

About