Population Genetics of<i>Campylobacter</i>

Sheppard, Samuel K.; Maiden, Martin C. J.; Falush, Daniel

doi:10.1002/9780470600122.ch10

Cited by 5 publications

(5 citation statements)

References 56 publications

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“…Bacteria from both species show evidence of recombination within species and clade (for C. coli ) from a version of the four gamete test applied to the two most common MLST alleles in each clade population (Sheppard et al . ). This has contributed to generating the ‘star‐like’ phylogenies amongst the C. coli clade 2 and 3 isolates in our sample (Fig.…”

Section: Discussionmentioning

confidence: 97%

Progressive genome‐wide introgression in agricultural Campylobacter coli

et al. 2012

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Hybridization between distantly related organisms can facilitate rapid adaptation to novel environments, but is potentially constrained by epistatic fitness interactions among cell components. The zoonotic pathogens Campylobacter coli and C. jejuni differ from each other by around 15% at the nucleotide level, corresponding to an average of nearly 40 amino acids per protein-coding gene. Using whole genome sequencing, we show that a single C. coli lineage, which has successfully colonized an agricultural niche, has been progressively accumulating C. jejuni DNA. Members of this lineage belong to two groups, the ST-828 and ST-1150 clonal complexes. The ST-1150 complex is less frequently isolated and has undergone a substantially greater amount of introgression leading to replacement of up to 23% of the C. coli core genome as well as import of novel DNA. By contrast, the more commonly isolated ST-828 complex bacteria have 10–11% introgressed DNA, and C. jejuni and nonagricultural C. coli lineages each have <2%. Thus, the C. coli that colonize agriculture, and consequently cause most human disease, have hybrid origin, but this cross-species exchange has so far not had a substantial impact on the gene pools of either C. jejuni or nonagricultural C. coli. These findings also indicate remarkable interchangeability of basic cellular machinery after a prolonged period of independent evolution.

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Section: Discussionmentioning

confidence: 97%

Progressive genome‐wide introgression in agricultural Campylobacter coli

et al. 2012

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“…There is good evidence that novel diversity in Campylobacter is generated frequently by the continued movement of genes between lineages, more so even than by the evolution of new variants through mutation (Wilson et al , 2009; Sheppard et al , 2010). High levels of recombination lead to mosaic genomes with differing ancestral histories, and the full evolution of samples cannot be represented by a coalescent genealogy.…”

Section: Methodsmentioning

confidence: 99%

Rapid host switching in generalist Campylobacter strains erodes the signal for tracing human infections

et al. 2015

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Campylobacter jejuni and Campylobacter coli are the biggest causes of bacterial gastroenteritis in the developed world, with human infections typically arising from zoonotic transmission associated with infected meat. Because Campylobacter is not thought to survive well outside the gut, host-associated populations are genetically isolated to varying degrees. Therefore, the likely origin of most strains can be determined by host-associated variation in the genome. This is instructive for characterizing the source of human infection. However, some common strains, notably isolates belonging to the ST-21, ST-45 and ST-828 clonal complexes, appear to have broad host ranges, hindering source attribution. Here whole-genome sequencing has the potential to reveal fine-scale genetic structure associated with host specificity. We found that rates of zoonotic transmission among animal host species in these clonal complexes were so high that the signal of host association is all but obliterated, estimating one zoonotic transmission event every 1.6, 1.8 and 12 years in the ST-21, ST-45 and ST828 complexes, respectively. We attributed 89% of clinical cases to a chicken source, 10% to cattle and 1% to pig. Our results reveal that common strains of C. jejuni and C. coli infectious to humans are adapted to a generalist lifestyle, permitting rapid transmission between different hosts. Furthermore, they show that the weak signal of host association within these complexes presents a challenge for pinpointing the source of clinical infections, underlining the view that whole-genome sequencing, powerful though it is, cannot substitute for intensive sampling of suspected transmission reservoirs.

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“…b Llewellyn et al (2009aLlewellyn et al ( d , 2009bLlewellyn et al ( , 2011 b ) Sarkar and Guttman (2004) b,e Lymbery and Thompson (2012) c Sheppard et al (2010) b Minning et al (2011) a,b Smyth and Robinson (2010) b,e Miotto et al (2013) …”

Section: The Model Of Predominant Clonal Evolution and Its Last Develmentioning

confidence: 99%

“…Campylobacter coli is subdivided into three clearly differentiated clades (near-clades) (Sheppard et al, 2010).…”

Section: Bacteriamentioning

confidence: 99%

Is Predominant Clonal Evolution a Common Evolutionary Adaptation to Parasitism in Pathogenic Parasitic Protozoa, Fungi, Bacteria, and Viruses?

Tibayrenc

Ayala

2017

Advances in Parasitology

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Population Genetics ofCampylobacter

Cited by 5 publications

References 56 publications

Progressive genome‐wide introgression in agricultural Campylobacter coli

Progressive genome‐wide introgression in agricultural Campylobacter coli

Rapid host switching in generalist Campylobacter strains erodes the signal for tracing human infections

Is Predominant Clonal Evolution a Common Evolutionary Adaptation to Parasitism in Pathogenic Parasitic Protozoa, Fungi, Bacteria, and Viruses?

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