Population Genetic Studies of Red Cell Enzyme Polymorphisms in Four Spanish Populations

Goedde, H. W.; Hirth, L.; Benkmann, Heide‐G.; Pellicer, Antonio; Pellicer, T.; Stahn, Margrit; Singh, Sonika

doi:10.1159/000152537

Cited by 23 publications

(15 citation statements)

References 5 publications

(6 reference statements)

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“…19817 Moral et al, 19868 Ribo etal., 19869 Moral etal., 198510 Moral, 198611 M. de Pancorbo,198212 Martell et al, 1986 ards are shown in table 3. The values of ACP*A and ACP*B alleles found in this study are within the range of variation in the Basque populations previously stud ied, but the comparison with the yj test produced some significant differences with Basques [Goedde et al, 1972] and Biscayans [Iturrioz et al, 1983]. The heter ogeneity detected was caused by the lower values of allele ACP*C in our sample which, together with the Arratia popula tion [M. de Pancorbo et al, 1986], is the lowest value described in Basques.…”

Section: Resultssupporting

confidence: 81%

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Acid Phosphatase, Adenosine Deaminase and Esterase D Polymorphisms in the Spanish Basque Population

Aguirre

Vicario²,

Mazon³

et al. 1991

Hum Hered

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The 3 red-cell polymorphic systems acid phosphatase (ACP), adenosine deaminase (ADA) and esterase D (ESD) have been studied in a random sample of 1,112 individuals from the Basque country: The allelic frequencies obtained were ACP*A = 0.275, ACP*B = 0.718 and ACP*C = 0.007; ADA*2 = 0.021, and, ESD*2 = 0.066. The allelic frequencies have been compared with those of other Basque and other European populations. In comparison with Basques, significant differences were detected only for ACP, whereas as regards other Europeans significant differences were obtained with practically all the populations compared for the 3 genetic systems studied. The low values of the less frequent alleles, especially that for the ACP*C allele which is the lowest reported in Europe, are noteworthy.

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Section: Resultssupporting

confidence: 81%

“…1 Goedde et al, 19722 Vergnesetah, 1980a3 Iturrioz et ah, 19834 M. de Pancorbo et ah, 19865 Carracedo and Concheiro, 19826 Moreno and Moral. 19817 Ribo et ah, 19868 Moral et ah, 19869 Martell et ah, 1986 ing to the birth place of their grandparents.…”

Section: Introductionmentioning

confidence: 99%

Acid Phosphatase, Adenosine Deaminase and Esterase D Polymorphisms in the Spanish Basque Population

Aguirre

Vicario²,

Mazon³

et al. 1991

Hum Hered

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“…As for their genetic structure, the existence of a certain degree of genetic heterogeneity within the Basques has been suggested since the first population-based genetic analyses were performed (Goedde et al 1972(Goedde et al , 1973. On the one hand, some authors have claimed a lack of genetic substructure among the Basques based on investigations using both classical markers (Calafell and Bertranpetit 1994) and HLA genetic markers (Comas et al 1998).…”

Section: Introductionmentioning

confidence: 99%

Microsatellite data support subpopulation structuring among Basques

et al. 2005

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Genomic diversity based on 13 short tandem repeat (STR) loci (D3S1358, vWA, FGA, D8S1179, D21S11, D18S51, D5S818, D13S317, D7S820, D16S539, TH01, TPOX, and CSF1PO) is reported for the first time in Basques from the provinces of Guipu´zcoa and Navarre (Spain). STR data from previous studies on Basques from Alava and Vizcaya provinces were also examined using hierarchal analysis of molecular variance (AMOVA) and genetic admixture estimations to ascertain whether the Basques are genetically heterogeneous. To assess the genetic position of Basques in a broader geographic context, we conducted phylogenetic analyses based on F ST genetic distances [neighbor-joining trees and multidimensional scaling (MDS)] using data compiled in previous publications. The genetic profile of the Basque groups revealed distinctive regional partitioning of short tandem repeat (STR) diversity. Consistent with the above, native Basques clearly segregated from other populations from Europe (including Spain), North Africa, and the Middle East. The main line of genetic discontinuity inferred from the spatial variability of the microsatellite diversity in Basques significantly overlapped the geographic distribution of the Basque language. The genetic heterogeneity among native Basque groups correlates with the peculiar geography of peopling and marital structure in rural Basque zones and with language boundaries resulting from the uneven impact of Romance languages in the different Basque territories.

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“…The Ibiza pop ulation, as well as those of the other Balea ric islands [Miguel, 1988;Moral, 1986], ex hibits frequencies for ACPI*A similar to those published for the Basque country (north Spain) [Martinez de Pancorbo, 1982;Aguirre, 1987] and other Mediterra nean populations [Tsiakalos et al, 1981;Bonne-Tamir et al, 1978;Tills et al, 1983]. However, they differ from those reported from central and southern Spain [Goedde et al, 1972] and from central and northern European populations, which are charac terized by higher frequencies of this allele.…”

Section: Resultsmentioning

confidence: 51%

Red-Cell Enzyme Polymorphisms in Ibiza (Balearic Islands, Spain)

Miguel¹,

Petitpierre²

1989

Hum Hered

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A sample of 390 individuals from Ibiza (Balearic islands, Spain) was studied for the red-cell enzyme polymorphisms: esterase D (ESD), acid phosphatase 1 (ACP1), glyoxalase I (GLO), 6-phosphogluconate dehydrogenase (PGD), phosphoglucomutase 1 (PGM1) and adenylate kinase 1 (AK1). The following allele frequencies were observed: ESD*2 = 0.181; ACP*A = 0.249; ACP*B = 0.719; ACP*C = 0.032; GLO*2 = 0.556; PGD*C = 0.018; PGM1*2 = 0.235, and AK1*2 = 0.032. These results were compared with those reported from other Balearic populations. There was a heterogeneity between island samples in the ESD and PGD systems. In spite of this, the whole Balearic population could be differentiated from most European and circum-Mediterranean populations.

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Population Genetic Studies of Red Cell Enzyme Polymorphisms in Four Spanish Populations

Cited by 23 publications

References 5 publications

Acid Phosphatase, Adenosine Deaminase and Esterase D Polymorphisms in the Spanish Basque Population

Acid Phosphatase, Adenosine Deaminase and Esterase D Polymorphisms in the Spanish Basque Population

Microsatellite data support subpopulation structuring among Basques

Red-Cell Enzyme Polymorphisms in Ibiza (Balearic Islands, Spain)

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