Population genetic structure analysis and forensic evaluation of Xinjiang Uigur ethnic group on genomic deletion and insertion polymorphisms

Abstract

BackgroundThe Uigur ethnic minority is the largest ethnic group in the Xinjiang Uygur Autonomous Region of China, and valuable resource for the study of ethnogeny. The objective of this study was to estimate the genetic diversities and forensic parameters of 30 insertion-deletion loci in Uigur ethnic group from Xinjiang Uigur Autonomous Region of China and to analyze the genetic relationships between Xinjiang Uigur group and other previously published groups based on population data of these loci.ResultsAll the tested loci were conformed to Hardy–Weinberg equilibrium after Bonferroni correction. The observed and expected heterozygosity ranged from 0.3750 to 0.5515; and 0.4057 to 0.5037, respectively. The combined power of discrimination and probability of exclusion in the group were 0.99999999999940 and 0.9963, respectively. We analyzed the DA distance, interpopulation differentiations and population structure, conducted principal component analysis and neighbor-joining tree based on our studied group and 21 reference groups. The present results indicated that the studied Xinjiang Uigur group (represented our samples from the whole territory of Xinjiang Uigur Autonomous Region) had a close relationships with Urumchi Uigur (represented previously reported samples from Urumchi of Xinjiang) and Kazak groups.ConclusionsThe present study may provide novel biological information for the study of population genetics, and can also increase our understanding of the genetic relationships between Xinjiang Uigur group and other groups.Electronic supplementary materialThe online version of this article (doi:10.1186/s40064-016-2730-3) contains supplementary material, which is available to authorized users.

A set of novel SNP loci for differentiating continental populations and three Chinese populations

“…For Uygur, Han and Mongolian populations, previous research investigated their genetic variations based on different genetic markers (Mei et al, 2016; Tao et al, 2018). Tao et al (2018) assessed genetic polymorphisms of 12X-STRs and found that the Mongolian group showed indistinguishable genetic component distributions when compared to the components of Han populations in different regions.…”

“…Tao et al (2018) assessed genetic polymorphisms of 12X-STRs and found that the Mongolian group showed indistinguishable genetic component distributions when compared to the components of Han populations in different regions. Mei et al (2016) conducted genetic differentiation analyses between Uygur and other reference populations based on 30 InDels and found that Uygur group was far from Han populations and other Chinese populations in the PCA plot. In this study, we selected 48 SNPs to differentiate Han, Mongolian and Uygur populations.…”

Effect of zoledronic acid therapy on postmenopausal osteoporosis between the Uighur and Han population in Xinjiang: An open-label, long-term safety and efficacy study

“…Uighur is the major ethnic group there, accounting for 45.2% of the population compared with 40.6% with Han ethnicity . The Uighur population numbered 10.06 million in 2010 . They mainly live in Kashi, located in the south of Tianshan Mountain, and others are scattered in the Ili and Urumchi areas.…”

“…They mainly live in Kashi, located in the south of Tianshan Mountain, and others are scattered in the Ili and Urumchi areas. The Uighurs have their own language and their Islamic beliefs have a great influence on their culture and customs …”

Population Genetic Diversity and Clustering Analysis for Chinese Dongxiang Group With 30 Autosomal InDel Loci Simultaneously Analyzed

“…The commercially available Investigator DIPplex kit which contains 30 autosomal InDel loci and an amelogenin gene has been testified in a large majority of populations to evaluate its efficiency for forensic applications. Chinese population data including Tujia ( Shen et al, 2016 ), Uyghur ( Mei et al, 2016 ), Xibe ( Meng et al, 2015 ), Hui ( Xie et al, 2018 ), Dong ( Li et al, 2015 ), Tibetan ( Guo et al, 2016 ), Kazak ( Kong et al, 2017 ), Zhuang ( Li et al, 2015 ), and Yi ( Li et al, 2015 ) were reported previously. But data in existence did not incorporate Dongxiang ethnic minority in Gansu province of China.…”