Population dynamics of potentially harmful haplotypes: a pedigree analysis
Katherine D. Arias,
Iván Fernández,
Juan Pablo Gutiérrez
et al.
Abstract:Background
The identification of low-frequency haplotypes, never observed in homozygous state in a population, is considered informative on the presence of potentially harmful alleles (candidate alleles), putatively involved in inbreeding depression. Although identification of candidate alleles is challenging, studies analyzing the dynamics of potentially harmful alleles are lacking. A pedigree of the highly endangered Gochu Asturcelta pig breed, including 471 individuals belonging to 51 differ… Show more
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