Population differentiation of Phlebotomus perniciosus in Spain following postglacial dispersal

Aransay, Ana M.; Ready, P. D.; Morillas‐Márquez, F.

doi:10.1038/sj.hdy.6800246

Cited by 48 publications

(33 citation statements)

References 31 publications

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“…A precise dispersal pattern has not been hypothesized for P. perniciosus because too few populations have been characterized, but this sandfly requires Mediterranean summers and so it is unlikely to have followed all the colonization routes of temperate species. The analysis of allelic variation at five polymorphic microsatellite DNA loci has demonstrated strong genetic differentiation between populations of P. perniciosus from northeast Spain (including E_T_TOR) and southern Spain (Aransay et al, 2003), and the frequency distribution of GPI allele 1 in the current study (Tables II, III) is consistent with this. This conclusion might be strengthened by discovering additional polymorphic enzyme loci.…”

Section: Discussionsupporting

confidence: 85%

Postglacial dispersal ofPhlebotomus perniciosusinto France

et al. 2005

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Summary :Phlebotomus perniciosus was identified morphologically in samples from France and northeast Spain, and individuals were then characterized at three polymorphic isoenzyme loci (by isoelectrofocusing) and at the mitochondrial DNA locus (by comparative DNA sequence analysis of a fragment of the Cytochrome b gene). The four polymorphic loci gave conflicting patterns of population relationships, which can be explained by hypothesizing different amounts of gene introgression at each locus when two distinctive lineages met in southern France or northeast Spain after isolation in southern Italy and Spain during the Pleistocene Ice Ages. P. perniciosus is an important vector of Leishmania infantum and so these population differentiation studies are relevant for predicting the emergence and spread of leishmaniasis in relation to environmental changes, including climate. Résumé

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Section: Discussionsupporting

confidence: 85%

Postglacial dispersal ofPhlebotomus perniciosusinto France

et al. 2005

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“…A total of 83 intraspecific studies has been recorded in the literature (Esseghir et al, 1997;Marcondes et al, 1997;Dias et al, 1998;Aransay et al, 2000Aransay et al, , 2003Di Muccio et al, 2000;Esseghir and Ready, 2000;Mukhopadhyay et al, 2000;Yin et al, 2000;Marquez et al, 2001;Soto et al, 2001;Arrivillaga et al, 2002Arrivillaga et al, , 2003Bauzer et al, 2002a,b;Depaquit et al, , 2004aDepaquit et al, , 2005bDepaquit et al, , 2008bDepaquit et al, , 2013Depaquit et al, , 2014Hodgkinson et al, 2002Hodgkinson et al, , 2003Testa et al, 2002;Bottecchia et al, 2004;Margonari et al, 2004;Pesson et al, 2004;Yahia et al, 2004;Elnaiem et al, 2005;Meneses et al, 2005;Perrotey et al, 2005;Dvorak et al, 2006Dvorak et al, , 2011Mazzoni et al, 2006Mazzoni et al, , 2008de Souza Rocha et al, 2007;Hamarsheh et al, 2007;Moin-Vaziri et al, 2007a,b;Baron et al, 2008;Bounamous et al, 2008Bounamous et al, , 2014Lins et al, 2008…”

Section: Resultsmentioning

confidence: 99%

“…-Proteins like isoenzymes (Miles and Ward, 1978;Caillard et al, 1986;Ryan et al, 1986;Perrotti et al, 1991;Pesson et al, 1991;Zhang and Leng, 1991;Lanzaro et al, 1993;Maingon et al, 1993;Zeledon et al, 1993;Dujardin et al, 1996;RemyKristensen et al, 1996;Dujardin et al, 1997;Mukhopadhyay et al, 1998;Munstermann et al, 1998;Benabdennbi et al, 1999;Kassem et al, 1999;Lampo et al, 1999;Arrivillaga et al, 2000;Perrotey et al, 2000;Feliciangeli and Lampo, 2001;Marquez et al, 2001;Mukhopadhyay et al, 2001;Zhang and Leng, 2002;Aransay et al, 2003;Arrivillaga et al, 2003;Torgerson et al, 2003;Belen et al, 2004;Dujardin et al, 2004;Pesson et al, 2004;Meneses et al, 2005;Perrotey et al, 2005;Boussaa et al, 2008a,b;Hernández et al, 2008;…”

Section: Introductionmentioning

confidence: 96%

Molecular systematics applied to Phlebotomine sandflies: Review and perspectives

Depaquit

2014

Infection, Genetics and Evolution

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“…Monitoring of the vector showed that P. perniciosus was present, a species that has been traditionally described in Spain and Madrid [25][26][27] and was found in high density in the epidemic area. An extension of the presence of this vector both in latitude and altitude has also been observed.…”

Section: Discussionmentioning

confidence: 99%

Re-emergence of leishmaniasis in Spain: community outbreak in Madrid, Spain, 2009 to 2012

et al. 2013

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Since July 2009, there has been a community outbreak of leishmaniasis in the south-west area of the Madrid autonomous community, Spain, affecting residents from four towns that are geographically close together and share extensive park areas. As of December 2012, 446 cases were reported (6 in 2009, 97 in 2010, 196 in 2011 and 147 in 2012), a mean incidence rate of 22.2 per 100,000 inhabitants during July 2009 and December 2012. The mean age was 44 years (range: 2 months to 95 years); 61.0% were male. A total of 68 (15.2%) had immunosuppressive conditions; 160 (35.9%) had visceral leishmaniasis and 286 (64.1%) cutaneous. A total of 421 (94.4%) cases were confirmed. Leishmania infantum was identified as the agent. Monitoring revealed high densities of the vector Phlebotomus perniciosus. The surveillance system for canine leishmaniasis did not detect any increase in prevalence during the period. Environmental control measures have been taken, such as improvements in sanitation and disinsection in the risk areas and control of the overpopulation of Leporidae, as xenodiagnosis studies have shown that hares play a role as active reservoirs. This is the largest reported community outbreak of leishmaniasis in Europe. The discovery of the new reservoir stands out in the multifactorial aetiology of the outbreak. Epidemiological research and environmental intervention measures are continuing.

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Population differentiation of Phlebotomus perniciosus in Spain following postglacial dispersal

Cited by 48 publications

References 31 publications

Postglacial dispersal ofPhlebotomus perniciosusinto France

Postglacial dispersal ofPhlebotomus perniciosusinto France

Molecular systematics applied to Phlebotomine sandflies: Review and perspectives

Re-emergence of leishmaniasis in Spain: community outbreak in Madrid, Spain, 2009 to 2012

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