Population-Based Study of First Onset and Chronicity in Major Depressive Disorder

Eaton, William W.; Shao, Huibo; Nestadt, Gerald; Lee, Ho-Chang; Bienvenu, O. Joseph; Zandi, Peter P.

doi:10.1001/archpsyc.65.5.513

Cited by 513 publications

(419 citation statements)

References 57 publications

(59 reference statements)

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“…El porcentaje de síntomas catatónicos y característi-cas atípicas se enmarcan dentro de lo descrito 30,33 . Dado que la muestra está conformada por pacientes graves y/o con falta de respuesta terapéutica, se esperaba este porcentaje de EDM crónicos (26,8%) superior al de la población general (15%) 34 .…”

Section: Discussionunclassified

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Características clínicas del trastorno depresivo mayor en tratamiento en el nivel secundario de atención

Salvo

Saldivia

Parra³

et al. 2017

Rev. méd. Chile

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Section: Discussionunclassified

“…Si bien nuestro estudio es corto en seguimiento para recurrencia y cronicidad, la tendencia de la remisión más lo publicado por otros autores reafirman la cronicidad y menor respuesta terapéutica en un grupo de pacientes 19,21,34,46 .…”

Section: Discussionunclassified

Características clínicas del trastorno depresivo mayor en tratamiento en el nivel secundario de atención

Salvo

Saldivia

Parra³

et al. 2017

Rev. méd. Chile

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“…These disorders tend to have a relapsing course ; in the large UK birth cohort that has been followed to the age of 53, 70 % of adolescents who had emotional disorders at both ages 13 and 15 had mental disorders at age 36, 43 or 53, compared with about 25 % of the mentally healthy adolescents (Colman et al 2007). Studies of single disorders tend to have a shorter follow-up period, and depend on the severity of the first episode of disorder ; thus, Eaton et al (2008) followed first episodes of depression in a community sample for at least 13 years and showed that half had only a single episode, whereas 35 % had recurrent episodes and 15 % were unremitting. Brodaty et al (2001) followed depressives who had been admitted to hospital for 25 years, and showed that only 12 % had recovered and were well whereas 84 % had had recurrences.…”

Section: Coursementioning

confidence: 99%

Emotional disorders: Cluster 4 of the proposed meta-structure for DSM-V and ICD-11

et al. 2009

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"Emotional disorders: Cluster 4 of the proposed meta-structure for DSM-V and ICD-11." Psychological Medicine.39,12. 2043-2059. http://digitalcommons.wustl.edu/open_access_pubs/3923Emotional disorders: Cluster 4 of the proposed meta-structure for DSM-V and ICD-11Paper 5 of 7 of the thematic section : ' A proposal for a meta-structure for DSM-V and ICD-11 ' Background. The extant major psychiatric classifications DSM-IV, and ICD-10, are atheoretical and largely descriptive. Although this achieves good reliability, the validity of a medical diagnosis would be greatly enhanced by an understanding of risk factors and clinical manifestations. In an effort to group mental disorders on the basis of aetiology, five clusters have been proposed. This paper considers the validity of the fourth cluster, emotional disorders, within that proposal.Method. We reviewed the literature in relation to 11 validating criteria proposed by a Study Group of the DSM-V Task Force, as applied to the cluster of emotional disorders.Results. An emotional cluster of disorders identified using the 11 validators is feasible. Negative affectivity is the defining feature of the emotional cluster. Although there are differences between disorders in the remaining validating criteria, there are similarities that support the feasibility of an emotional cluster. Strong intra-cluster co-morbidity may reflect the action of common risk factors and also shared higher-order symptom dimensions in these emotional disorders.Conclusion. Emotional disorders meet many of the salient criteria proposed by the Study Group of the DSM-V Task Force to suggest a classification cluster.

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“…almost 75 % were in-patients, 90 % probable or definite endogenous subtype ; Solomon et al 2000), and are subject to biases that almost without question inflate these recurrence estimates (e.g. Berkson bias, the ' clinician's illusion ' ; Berkson, 1946 ;Cohen & Cohen, 1984 Baltimore site of the Epidemiologic Catchment Area (ECA) Study culled out 92 cases with a first lifetime onset of MDD occurring over a minimum follow-up period of 13 years (Eaton et al 2008). This latter investigation, using a population-based sample, provides an important counterpart to other studies on the lifetime course of depression.…”

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confidence: 99%

“…The question needs to be enlarged to face the inconvenient but inescapable fact that depression can be either, that depression as we currently conceive and define the condition is ' both '. The evidence is prima facie : approximately half of people who become depressed never do so again, and approximately half do (Eaton et al 2008). In recognizing and resolving this seeming paradox, and by adding the acute depressive conditions that do not recur to the research agenda, early indices of recurrence risk may be found, and the trajectory of depression that is so chronic, severe and disabling eventually may be altered for the betterment of so very many.…”

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confidence: 99%

Is depression a chronic mental illness?

Monroe

Harkness

2011

Psychol. Med.

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Over the past few decades, theory and research on depression have increasingly focused on the recurrent and chronic nature of the disorder. These recurrent and chronic forms of depression are extremely important to study, as they may account for the bulk of the burden associated with the disorder. Paradoxically, however, research focusing on depression as a recurrent condition has generally failed to reveal any useful early indicators of risk for recurrence. We suggest that this present impasse is due to the lack of recognition that depression can also be an acute, timelimited condition. We argue that individuals with acute, single lifetime episodes of depression have been systematically eclipsed from the research agenda, thereby effectively preventing the discovery of factors that may predict who, after experiencing a first lifetime episode of depression, goes on to have a recurrent or chronic clinical course. Greater awareness of the high prevalence of people with a single lifetime episode of depression, and the development of research designs that identify these individuals and allow comparisons with those who have recurrent forms of the disorder, could yield substantial gains in understanding the lifetime pathology of this devastating mental illness.

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Population-Based Study of First Onset and Chronicity in Major Depressive Disorder

Abstract: Major depressive disorder is unremitting in 15% of cases and recurrent in 35%. About half of those with a first-onset episode recover and have no further episodes.

Cited by 513 publications

References 57 publications

Características clínicas del trastorno depresivo mayor en tratamiento en el nivel secundario de atención

Características clínicas del trastorno depresivo mayor en tratamiento en el nivel secundario de atención

Emotional disorders: Cluster 4 of the proposed meta-structure for DSM-V and ICD-11

Is depression a chronic mental illness?

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