Population‐based study for human papillomavirus (HPV) infection in young women in Japan: A multicenter study by the Japanese human papillomavirus disease education research survey group (J‐HERS)

Abstract

A multi-center study was conducted to examine 6,628 eligible Japanese women aged from 16 to 50 years for uterine cervical abnormality and HPV infection with a liquid based-cytology test and a novel HPV test using the PCR-SSOP-Luminex(®) method identifying 31 HPV genotypes. In 3,047 normal subjects, the overall prevalence across all HPV types was 25%, while that of the common 13 high-risk (Common-13HR) types (HPV-16, 18. 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68) was 17%, and that of the definite high-risk (Definite-HR) types (HPV-16, 18. 31, 33, 35, 45, 52, and 58) was 12%. For Definite-HR, HPV-52, 16, and 58 were the most common, HPV-31 was relatively common, and HPV-18 was less common, while HPV-33, 35, and 45 were rare. Seven Definite-HR excluding HPV-45 and seven Possible-HR (HPV-39, 51, 56, 66, 68, 70, and 82) HPV types were identified as a single type infection in patients with high-grade squamous intraepithelial lesion (HSIL) or worse. The Common-13HR types were detected in 89% of subjects with HSIL, whereas either Definite-HR or Possible-HR types were detected in 95% of HSIL. These 1420 HPV types appear to be involved with HSIL or worse in Japan. The prevalences of multiple-type HPV infections were identified in roughly half of HPV-positive subjects, and decreased significantly with age in normal population and abnormal cytology groups, although the prevalences of single-type infections increased with age in the latter group. Most HPV infections are cleared for some years, while a certain HR-HPV type persists to induce HSIL.

A population-based study of cervical cytology findings and human papillomavirus infection in a suburban area of Thailand

“…This study revealed low HR-HPV prevalence (5.6% overall, 4.1% in women with normal cytology) in women from a suburban area of Thailand, which was lower than that reported in population-based studies from Western countries (24.0–28.3%) (Bonde et al, 2014, Tachezy et al, 2013). Compared with other population-based studies in Asia, this HR-HPV rate was lower than reported in Japan (17%), China (21.07%), India (10.3%), Indonesia (7.9%), and Nepal (6.1%), but marginally higher than reported in Bangladesh (4.2%) (Nahar et al, 2014, Sankaranarayanan et al, 2009, Sasagawa et al, 2016, Sherpa et al, 2010, Vet et al, 2008, Wang et al, 2015). …”

“…2A). HPV-52 is particularly prevalent in Asian populations (Sasagawa et al, 2016, Vet et al, 2008, Wang et al, 2015). However, the number of women with each HPV type in this study was too low to definitively confirm the most common HPV type.…”

A study of the relationship between nuclear contour thickening, nuclear enlargement and human papillomavirus infection in squamous cells

“…All samples tested positive for β-globin, demonstrating that amplifiable DNA had been extracted from the specimens. Only high-risk HPV types were detected in the present study, namely HPV-16, -18, -31, -33, -35, -39, -45, -51, -52, -56, -58, -59 and -68 11.…”

Systematic review of the incidence and prevalence of genital warts

“…Among studies with the general female population, the reported annual incidence of any AGWs (including new and recurrent) per 100,000 population ranged between 99 among women of all ages in Germany [37] and 251 among 10- to 59-year-old women attending Pap screening in Japan [42], with a median of 224 (Table 1) [2,27,29,37-40,42,43]. The Italian prospective study [41] reported a much lower incidence compared to this range, of four cases per 100,000 females listed with GPs.…”