Population based studies of biological antirheumatic drug use in southern Sweden: comparison with pharmaceutical sales

Geborek, Pierre; Nitelius, E; Noltorp, Sven; Petri, H.; Jacobsson, Lennart; Larsson, Ludvig; Saxne, Tore; Leden, Ido

doi:10.1136/ard.2005.036715

Cited by 44 publications

(41 citation statements)

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“…The aim is to register all patients with rheumatological diseases who are prescribed biological drugs. Data are collected using a structured clinical protocol designed for drug monitoring 3,4 . Earlier validation against pharmaceutical sales showed that the register covers about 90% of the prescription of biological drugs in the region, where the population structure is representative for the whole of Sweden 4 .…”

Section: Methodsmentioning

confidence: 99%

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Differences in Longitudinal Disease and Treatment Characteristics of Patients with Rheumatoid Arthritis Replying and Not Replying to a Postal Questionnaire. Experience from a Biologics Register in Southern Sweden

Söderlin

Jacobsson²,

Petersson³

et al. 2009

J Rheumatol

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Patients with RA in a Swedish biologics register not replying to a postal questionnaire had more severe RA and stopped biological drug treatment more frequently. Thus a detailed analysis of prospectively collected data can clarify selection bias introduced by subjects who do not answer a postal questionnaire, which may influence the validity and interpretation of results from postal survey studies.

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Section: Methodsmentioning

confidence: 99%

“…We used the South Swedish Arthritis Treatment Group (SSATG) register, which contains prospectively collected baseline and followup data on disease severity and treatment outcome 3,4 .…”

mentioning

confidence: 99%

Differences in Longitudinal Disease and Treatment Characteristics of Patients with Rheumatoid Arthritis Replying and Not Replying to a Postal Questionnaire. Experience from a Biologics Register in Southern Sweden

Söderlin

Jacobsson²,

Petersson³

et al. 2009

J Rheumatol

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“…For example, administration of TNF blockers to patients with rheumatoid arthritis was found to increase the risk for developing lymphomas (95). Similarly, suppression or deletion of NF-jB has been associated with progression to carcinogenesis (68, 92, 261, 274, 312).…”

mentioning

confidence: 99%

Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy

Gupta

Hevia

Patchva

et al. 2012

Antioxidants & Redox Signaling

607

464

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Significance: Extensive research during the last quarter century has revealed that reactive oxygen species (ROS) produced in the body, primarily by the mitochondria, play a major role in various cell-signaling pathways. Most risk factors associated with chronic diseases (e.g., cancer), such as stress, tobacco, environmental pollutants, radiation, viral infection, diet, and bacterial infection, interact with cells through the generation of ROS. Recent Advances: ROS, in turn, activate various transcription factors (e.g., nuclear factor kappa-light-chain-enhancer of activated B cells [NF-jB], activator protein-1, hypoxia-inducible factor-1a, and signal transducer and activator of transcription 3), resulting in the expression of proteins that control inflammation, cellular transformation, tumor cell survival, tumor cell proliferation and invasion, angiogenesis, and metastasis. Paradoxically, ROS also control the expression of various tumor suppressor genes (p53, Rb, and PTEN). Similarly, c-radiation and various chemotherapeutic agents used to treat cancer mediate their effects through the production of ROS. Interestingly, ROS have also been implicated in the chemopreventive and anti-tumor action of nutraceuticals derived from fruits, vegetables, spices, and other natural products used in traditional medicine. Critical Issues: These statements suggest both ''upside'' (cancer-suppressing) and ''downside'' (cancer-promoting) actions of the ROS. Thus, similar to tumor necrosis factor-a, inflammation, and NF-jB, ROS act as a double-edged sword. This paradox provides a great challenge for researchers whose aim is to exploit ROS stress for the development of cancer therapies. Future Directions: The various mechanisms by which ROS mediate paradoxical effects are discussed in this article. The outstanding questions and future directions raised by our current understanding are discussed. Antioxid. Redox Signal. 16, 1295Signal. 16, -1322

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“…Exposure to anti-TNF treatment has been recorded continuously and independently as part of a regional follow-up system for patients with rheumatological diseases treated with biologics: the South Swedish Arthritis Treatment Group (SSATG) register (11). A total of 10 rheumatology centres report to the SSATG register, which has been compared to pharmaceutical sales data and found to cover over 90% of anti-TNF-treated patients in the area (11).…”

Section: Methodsmentioning

confidence: 99%

“…A total of 10 rheumatology centres report to the SSATG register, which has been compared to pharmaceutical sales data and found to cover over 90% of anti-TNF-treated patients in the area (11). Patients with a history of ExRA before 1 July 1997 or who had a first biological therapy other than TNF inhibitors (i.e.…”

Section: Methodsmentioning

confidence: 99%

Extra-articular manifestations in a community-based sample of patients with rheumatoid arthritis: incidence and relationship to treatment with TNF inhibitors

Petersson

Jacobsson

et al. 2012

Scandinavian Journal of Rheumatology

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Population based studies of biological antirheumatic drug use in southern Sweden: comparison with pharmaceutical sales

Cited by 44 publications

References 1 publication

Differences in Longitudinal Disease and Treatment Characteristics of Patients with Rheumatoid Arthritis Replying and Not Replying to a Postal Questionnaire. Experience from a Biologics Register in Southern Sweden

Differences in Longitudinal Disease and Treatment Characteristics of Patients with Rheumatoid Arthritis Replying and Not Replying to a Postal Questionnaire. Experience from a Biologics Register in Southern Sweden

Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy

Extra-articular manifestations in a community-based sample of patients with rheumatoid arthritis: incidence and relationship to treatment with TNF inhibitors

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