Population-based prevalence of fetal alcohol spectrum disorder in Canada

Popova, Svetlana; Lange, Shannon; Poznyak, Vladimir; Chudley, Albert E.; Shield, Kevin D.; Reynolds, James N.; Murray, Margaret; Rehm, Jürgen

doi:10.1186/s12889-019-7213-3

Cited by 90 publications

(78 citation statements)

References 18 publications

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“…Alcohol consumption during pregnancy and the peri-conception period is associated with fetal alcohol spectrum disorders (FASD), and a host of other obstetric complications [4,6,7]. FASD is a grave, yet preventable, complication of maternal alcohol consumption.…”

Section: Introductionmentioning

confidence: 99%

Alcohol use and its associated factors during pregnancy in Ethiopia: a population-based survey

Addis

Azage

Nigatu

et al. 2020

Preprint

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Background: Alcohol use during pregnancy is a modifiable health behavior that causes a range of health problems in infants, including impaired growth, stillbirth, and fetal alcohol spectrum disorder. However, there is lack of comprehensive information on alcohol use and associated factors during pregnancy using a population-based dataset in Ethiopia. Therefore, this study aimed to assess the prevalence of alcohol use during pregnancy and associated factors using a national, population-based survey.Methods: The study utilized data from the 2011 and 2016 Ethiopian Demographic and Health Survey, a cross-sectional survey conducted on a nationally representative sample. The survey employed a multistage cluster sampling method to generate representative national and sub-national health and health related indicators. A total of 2,341 pregnant women were included in the analysis. Factors associated with alcohol use were identified using multivariable logistic regression model. Adjusted odds ratios (AOR) with 95% confidence interval (CI) were computed to quantify the degree of association between independent variables and alcohol use.Results: In Ethiopia, the prevalence of alcohol use among pregnant women was 30.2% (95% CI: 28.4%-32.2%). The study identified that being employed (AOR: 2.07; 95%CI: 1.55-2.77), ever attempted termination of pregnancy (AOR: 2.21; 95% CI: 1.60-3.05), having two (AOR: 2.56; 95% CI: 1.76-3.72), or three (AOR: 2.98; 95% CI: 1.40-6.35) sexual partners in lifetime and chat chewing (AOR: 8.91; 95% CI: 4.61-17.23) had increased the odds of alcohol use during pregnancy.Conclusion: In this study, the prevalence of alcohol use during pregnancy among Ethiopian mothers was high. Working status, ever used something to terminate the pregnancy, more than one lifetime partner, and chat chewing were factors associated with alcohol use during pregnancy. Thus, prevention interventions and strategies can draw on the identified modifiable health behaviors.

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Section: Introductionmentioning

confidence: 99%

Alcohol use and its associated factors during pregnancy in Ethiopia: a population-based survey

Addis

Azage

Nigatu

et al. 2020

Preprint

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“…ACA studies in elementary schools emerged as an effective approach to fill this knowledge gap. Studies of whole communities were published from South Africa, Italy, Croatia, and Canada (May et al, 2000, 2006, 2007, 2011a, 2013a, 2016a, 2016b, 2017a; Okulicz‐Kozaryn et al, 2017; Petkovic and Barisic, 2010, 2013; Popova et al, 2019; Urban et al, 2008, 2015; Viljoen et al, 2002, 2005). Rates of FAS and FASD varied in these studies by county and over time.…”

Section: Previous Epidemiology Studies Of Children With Fasdmentioning

confidence: 99%

Fetal Alcohol Spectrum Disorders in a Southeastern County of the United States: Child Characteristics and Maternal Risk Traits

May

Hasken

Stegall

et al. 2020

Alcoholism Clin & Exp Res

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Objective: To detail the characteristic traits of children with fetal alcohol spectrum disorders (FASDs) and maternal risk factors in a southeastern U.S. County.Methods: Independent samples were drawn from 2 different cohorts of first-grade students. All consented children (49.8%) were measured for height, weight, and head circumference, and those ≤ 25th centile entered the study along with a random sample drawn from all enrolled students. Study children were examined for physical growth, dysmorphology, and neurobehavior, and their mothers were interviewed.Results: Total dysmorphology scores discriminated well the physical traits of children across the FASD continuum: fetal alcohol syndrome (FAS) = 15.8, partial FAS (PFAS) = 10.8, alcohol-related neurobehavioral disorder (ARND) = 5.2, and typically developing controls = 4.4. Additionally, a neurobehavioral battery distinguished children with each FASD diagnosis from controls. Behavioral problems qualified more children for FASD diagnoses than cognitive traits. Significant proximal maternal risk variables were as follows: reports of prepregnancy drinking, drinking in any trimester, and comorbid use of other drugs in lifetime and during pregnancy, especially alcohol and marijuana (14.9% among mothers of children with FASD vs. 0.4% for controls). Distal maternal risks included reports of other health problems (e.g., depression), living unmarried with a partner during pregnancy, and a lower level of spirituality. Controlling for other drug use during pregnancy, having a child diagnosed with a FASD was 17.5 times greater for women who reported usual consumption of 3 drinks per drinking day prior to pregnancy than for nondrinking mothers (p < 0.001, 95% CI = 5.1 to 59.9). There was no significant difference in the prevalence of FASD by race, Hispanic ethnicity, or socioeconomic status. The prevalence of FASD was not lower than 17.3 per 1,000, and weighted estimated prevalence was 49.0 per 1,000 or 4.9%.Conclusion: This site had the second lowest rate in the CoFASP study, yet children with FASD are prevalent.

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“…Of 187 countries, South Africa was estimated to have the highest prevalence of FASD at 7% to 16% population, followed by Croatia at 3% to 8%, and Ireland at 3% to 7% of population (Lange et al, ; Popova, Lange, Probst, Gmel, & Rehm, ). Additionally, FASD has been recognized as an important economic and health burden on the society (Popova et al, ). Considering that prenatal alcohol exposure is perhaps one of the most preventable causes of birth defects and developmental delay problems, it is therefore crucial to understand the causes of FASD.…”

Section: Chemical Agentsmentioning

confidence: 99%

The role of teratogens in neural crest development

Cerrizuela

Vega-Lopez

Aybar

2020

Birth Defects Research

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The neural crest (NC), discovered by Wilhelm His 150 years ago, gives rise to a multipotent migratory embryonic cell population that generates a remarkably diverse and important array of cell types during the development of the vertebrate embryo. These cells originate in the neural plate border (NPB), which is the ectoderm between the neural plate and the epidermis. They give rise to the neurons and glia of the peripheral nervous system, melanocytes, chondrocytes, smooth muscle cells, odontoblasts and neuroendocrine cells, among others. Neurocristopathies are a class of congenital diseases resulting from the abnormal induction, specification, migration, differentiation or death of NC cells (NCCs) during embryonic development and have an important medical and societal impact. In general, congenital defects affect an appreciable percentage of newborns worldwide. Some of these defects are caused by teratogens, which are agents that negatively impact the formation of tissues and organs during development. In this review, we will discuss the teratogens linked to the development of many birth defects, with a strong focus on those that specifically affect the development of the NC, thereby producing neurocristopathies.Although increasing attention is being paid to the effect of teratogens on embryonic development in general, there is a strong need to critically evaluate the specific role of these agents in NC development. Therefore, increased understanding of the role of these factors in NC development will contribute to the planning of strategies aimed at the prevention and treatment of human neurocristopathies, whose etiology was previously not considered.

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Population-based prevalence of fetal alcohol spectrum disorder in Canada

Cited by 90 publications

References 18 publications

Alcohol use and its associated factors during pregnancy in Ethiopia: a population-based survey

Alcohol use and its associated factors during pregnancy in Ethiopia: a population-based survey

Fetal Alcohol Spectrum Disorders in a Southeastern County of the United States: Child Characteristics and Maternal Risk Traits

The role of teratogens in neural crest development

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