Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study design

Castaño‐Vinyals, Gemma; Aragonés, Núria; Pérez‐Gómez, Beatriz; Martín, Vicente; Llorca, Javier; Moreno, Vı́ctor; Altzibar, Jone M.; Ardanáz, Eva; Sanjosé, Sílvia de; Jiménez-Moleón, José Juan; Tardón, Adonina; Alguacil, Juan; Peiró, Rosana; Marcos‐Gragera, Rafael; Navarro, Carmen; Pollán, Marina; Kogevinas, Manolis

doi:10.1016/j.gaceta.2014.12.003

Cited by 173 publications

(209 citation statements)

References 23 publications

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“…The questionnaire is available on the website of the study (www.mccspain.org). Further information can be found elsewhere [15]. In the present study, we have selected only the 2,165 colorectal cancer cases recruited in MCC-Spain and their 3,912 frequency matched controls.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Relationship between drugs affecting the renin-angiotensin system and colorectal cancer: The MCC-Spain study

Dierssen-Sotos

Gómez‐Acebo

Palazuelos

et al. 2017

Preventive Medicine

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The potential protective effect of Renin-angiotensin system (RAS) inhibitors is a subject of increasing interest due to their possible role as chemopreventive agents against colorectal cancer (CRC). To evaluate this association, we conducted a case-control study with 2,165 cases of colorectal cancer, diagnosed between 2007 and 2012, and 3,912 population controls frequency matched (by age, sex and region) from the Spanish multicenter case-control study MCC-Spain. We found a significant protective effect of the Angiotensin-converting enzyme Inhibitors (ACEIs) against CRC, limited to the under-65 years group (OR=0.65 95%CI (0.48-0.89)) and to a lesser degree to men (OR=0.81 95%CI (0.66-0.99). In contrast, the angiotensin receptor blockers (ARBs) did not show a significant effect. Regarding the duration of use, a greater protection was observed in men as the length of consumption increases. In contrast, in the under-65 stratum, the strongest association was found in short-term treatments. Finally, by analyzing ACEIs effect by colon subsite, we found no differences, except for under 65 years old, where the maximum protection was seen in the proximal intestine, descending in the distal and rectum (without statistical significance). In conclusion, our study shows a protective effect on CRC of the ACEis limited to males and people under 65 years old, which increases in proximal colon in the latter. If confirmed, these results may suggest a novel approach to proximal CRC prevention, given the shortcomings of colonoscopy screening in this location.

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Section: Accepted Manuscriptmentioning

confidence: 99%

Relationship between drugs affecting the renin-angiotensin system and colorectal cancer: The MCC-Spain study

Dierssen-Sotos

Gómez‐Acebo

Palazuelos

et al. 2017

Preventive Medicine

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“…The aim of MCC-Spain was to study factors related to some of the most relevant tumors in the Spanish population (breast, colorectal, gastroesophageal, and prostate cancer and chronic lymphocytic leukemia) in seven Spanish regions (Castano-Vinyals et al, 2015). Controls were randomly selected using population health data centers and contacted telephonically.…”

Section: Study Populationmentioning

confidence: 99%

“…The protocol of MCC-Spain was approved by the ethics committees of the participating institutions. All participants were informed about the study objectives and signed an informed consent form (Castano-Vinyals et al, 2015).…”

Section: Study Populationmentioning

confidence: 99%

“…The questionnaires included lifestyle factors, sociodemographic characteristics, occupational and personal factors, and medical and family histories. A self-administered questionnaire on dietary habits during the previous year was also administered to participants (Castano-Vinyals et al, 2015). The questionnaires are supplied as supplementary material.…”

Section: Independent Variablesmentioning

confidence: 99%

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Levels and predictors of persistent organic pollutants in an adult population from four Spanish regions

Fernández-Rodríguez

Arrebola

Artacho‐Cordón

et al. 2015

Science of The Total Environment

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“…This study is part of a population-based case-control study of colorectal cancer, which in turn is part of a larger multicase- 46 A subset of population-based controls who provided a blood sample (81% among the recruited) were selected using a stratified random selection based on residence in Barcelona metropolitan area (4 municipalities), age at recruitment (>60 years), and availability of lifetime estimates of THM levels (see below). Study subjects were frequency matched by age group (60-70 vs. 70-80 y) and THM levels (<85 mg/L vs. 85 mg/L, the median).…”

Section: Study Populationmentioning

confidence: 99%

DNA methylation levels and long-term trihalomethane exposure in drinking water: an epigenome-wide association study

et al. 2015

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Trihalomethanes (THM) are undesired disinfection byproducts (DBPs) formed during water treatment. Mice exposed to DBPs showed global DNA hypomethylation and c-myc and c-jun gene-specific hypomethylation, while evidence of epigenetic effects in humans is scarce. We explored the association between lifetime THM exposure and DNA methylation through an epigenome-wide association study. We selected 138 population-based controls from a casecontrol study of colorectal cancer conducted in Barcelona, Spain, exposed to average lifetime THM levels 85 mg/L vs. >85 mg/L (N D 68 and N D 70, respectively). Mean age of participants was 70 years, and 54% were male. Average lifetime THM level in the exposure groups was 64 and 130 mg/L, respectively. DNA was extracted from whole blood and was bisulphite converted to measure DNA methylation levels using the Illumina HumanMethylation450 BeadChip. Data preprocessing was performed using RnBeads. Methylation was compared between exposure groups using empirical Bayes moderated linear regression for CpG sites and Gaussian kernel for CpG regions. ConsensusPathDB was used for gene set enrichment. Statistically significant differences in methylation between exposure groups was found in 140 CpG sites and 30 gene-related regions, after false discovery rate <0.05 and adjustment for age, sex, methylation first principal component, and blood cell proportion. The annotated genes were localized to several cancer pathways. Among them, 29 CpGs had methylation levels associated with THM levels (|Db| 0.05) located in 11 genes associated with cancer in other studies. Our results suggest that THM exposure may affect DNA methylation in genes related to tumors, including colorectal and bladder cancers. Future confirmation studies are required.

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Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study design

Abstract: This study, conducted within the Spanish Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), is a unique initiative to evaluate etiological factors for common cancers and will promote cancer research and prevention in Spain.

Cited by 173 publications

References 23 publications

Relationship between drugs affecting the renin-angiotensin system and colorectal cancer: The MCC-Spain study

Relationship between drugs affecting the renin-angiotensin system and colorectal cancer: The MCC-Spain study

Levels and predictors of persistent organic pollutants in an adult population from four Spanish regions

DNA methylation levels and long-term trihalomethane exposure in drinking water: an epigenome-wide association study

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