“…Historically, cannabis and its derivatives have been classified as a Schedule I controlled substance in the United States ( Mead, 2019 ), but recent changes in laws have approved its medical and recreational use in several States ( Smart and Pacula, 2019 ; Blanchette et al, 2022 ). With its increased popularity of legal and illegal consumption ( Lu et al, 2023 ), there is an increased interest in identifying methods to identify if a person is currently under the influence of cannabis or not, such as at work ( Macdonald et al, 2010 ) or while driving ( Martin et al, 2017 ). According to National Institutes of Justice, biofluid quantification of cannabis metabolites are unreliable markers of recent use ( National Institute of Justice, 2021 ), which may be attributed to their complex metabolism and lipophilic nature ( Chayasirisobhon, 2020 ), different modes of consumption ( Newmeyer et al, 2017 ; Zipursky et al, 2020 ), as well as the use of synthetic forms of cannabis ( Tagen and Klumpers, 2022 ).…”