Population-based estimates of the relation between breast cancer risk, tumor subtype, and family history

Welsh, Megan L.; Buist, Diana S.M.; Bowles, Erin J. Aiello; Anderson, Melissa L.; Elmore, Joann G.; Li, Christopher I.

doi:10.1007/s10549-008-0026-1

Cited by 23 publications

(22 citation statements)

References 32 publications

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“…The association with family history of breast cancer has been similar across breast cancer subtypes,(3, 6–11, 40) stronger for ER+ breast cancer,(12, 41) and stronger for ER− or TN breast cancer. (13, 14, 42) The strongest evidence comes from a pooled analysis of 12 studies in the Breast Cancer Association Consortium, where an association with family history of breast cancer was present across subtypes, but with a stronger association for basal-like breast cancer.…”

Section: Discussionmentioning

confidence: 92%

“…(1) Among African American women, estimates of the relative risk for first degree family history of breast cancer range from 1.65 to1.78,(2, 3) similar to findings from studies of European American and Asian women. (1, 4, 5) Among studies that reported results separately for estrogen receptor (ER) positive and ER− breast cancer, most reported similar associations by subtype,(3, 6–11) while one reported a stronger association with ER+ cancer(12) and two reported a stronger relation for ER− breast cancer. (13, 14) Only the Black Women’s Health Study reported on family history separately for ER+ and ER− breast cancer in African American women, with similar increases by subtype, but findings were based on small numbers.…”

Section: Introductionmentioning

confidence: 99%

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Family History of Cancer in Relation to Breast Cancer Subtypes in African American Women

Bethea

Rosenberg

Castro‐Webb

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Evidence on the relation of family history of cancers other than breast cancer to breast cancer risk is conflicting and most studies have not assessed specific breast cancer subtypes. Methods We assessed the relation of first degree family history of breast, prostate, lung, colorectal, ovarian, cervical cancer, and lymphoma or leukemia, to risk of estrogen receptor positive (ER+), ER−, and triple negative breast cancer in data from the African American Breast Cancer Epidemiology and Risk Consortium. Multivariable logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Results There were 3,023 ER+ and 1,497 ER− breast cancer cases (including 696 triple negative cases) and 17,420 controls. First degree family history of breast cancer was associated with increased risk of each subtype: OR=1.76 (95% CI 1.57–1.97) for ER+, 1.67 (1.42–1.95) for ER−, and 1.72 (1.38–2.13) for triple negative breast cancer. Family history of cervical cancer was associated with increased risk of ER− (OR=2.39, 95% CI 1.36–4.20), but not ER+ cancer. Family history of both breast and prostate cancer was associated with increased risk of ER+ (3.40, 2.42–4.79) and ER− (2.09, 1.21–3.63) cancer, but family history of both breast and lung cancer was associated only with ER− cancer (2.11, 1.29–3.46). Conclusions A family history of cancers other than breast may influence risk of breast cancer and associations may differ by subtype. Impact Greater surveillance and counseling for additional screening may be warranted for women with a family history of cancer.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Family History of Cancer in Relation to Breast Cancer Subtypes in African American Women

Bethea

Rosenberg

Castro‐Webb

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…We also did not consider the age at breast cancer diagnosis for relatives which can influence the breast cancer risk associated with family history (36). However, a recent population-based study suggested that the age of diagnosis of breast cancer in relatives does not substantially influence the risk of breast cancer associated with family history in women diagnosed over the age of 40 (48).…”

Section: Discussionmentioning

confidence: 99%

“…However, breast cancer in seconddegree relatives is reported with less accuracy than that in first-degree relatives (46), and is associated with lower risk of breast cancer than that in first-degree relatives (47,48). In one of the screening populations (NBSS) included in the present study, we have shown that compared with women with no family history, the relative risk of breast cancer for women with at least one affected first-degree was 1.44 (95% CI, 0.94-2.20) whereas for women with any first-or second-degree relative with breast cancer, the relative risk was only 1.14 (95% CI, 0.83-1.57; ref.…”

Section: Discussionmentioning

confidence: 99%

Family History, Mammographic Density, and Risk of Breast Cancer

Martin

Melnichouk

Guo

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Purpose: Mammographic density is a strong and highly heritable risk factor for breast cancer. The purpose of this study was to examine the extent to which mammographic density explains the association of family history of breast cancer with risk of the disease.Subjects and Methods: We carried out three nested case-control studies in screening programs that included in total 2,322 subjects (1,164 cases and 1,158 controls). We estimated the independent and combined associations of family history and percent mammographic density at baseline with subsequent breast cancer risk.Results: After adjustment for age and other risk factors, compared with women with no affected firstdegree relatives, percent mammographic density was 3.1% greater for women with one affected first-degree relative, and 7.0% greater for women with two or more affected relatives (P = 0.001 for linear trend across family history categories). The odds ratios for breast cancer risk were 1.37 [95% confidence interval (95% CI), 1.10-1.72] for having one affected relative, and 2.45 (95% CI, 1.30-4.62) for having two or more affected relatives (P for trend = 0.0002). Adjustment for percent mammographic density reduced these odds ratios by 16% and 14%, respectively. Percent mammographic density explained 14% (95% CI, 4-39%) of the association of family history (at least one affected first-degree relative) with breast cancer risk.Conclusions: Percent mammographic density has features of an intermediate marker for breast cancer, and some of the genes that explain variation in percent mammographic density might be associated with familial risk of breast cancer. Cancer Epidemiol Biomarkers Prev; 19(2); 456-63. ©2010 AACR.

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“…8,11 Furthermore, there have been many studies that compared epidemiological factors between tumor subtypes based on hormone receptor (HR) and HER2 status in the Western population [12][13][14][15][16][17][18][19] ; however, there has been only a few studies in the Asian population. 20,21 In this study, we describe the characteristics of breast cancer classified into tumor subtypes based on ER, PR and HER2 statuses and assess the heterogeneity in association with the epidemiological factors within tumor subtypes as evidence for the etiological differences between breast cancer subtypes through casecase analyses.…”

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confidence: 99%

Heterogeneity of epidemiological factors by breast tumor subtypes in Korean women: A case-case study

et al. 2014

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Breast cancer is heterogeneous in clinical behavior by subtypes; however, it is unclear how this heterogeneity is related to epidemiological factors. To evaluate the differences in epidemiological factors by breast tumor subtypes, we investigated the associations of epidemiological factors between tumor subtypes in Korean women. From the Seoul Breast Cancer Study, a total of 3,058 patients with breast cancer were included in the analyses. Tumor subtypes were classified based on hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) statuses. The epidemiological factors of each subtype were compared through case-case analyses using multivariate a polytomous logistic regression model adjusted for age and recruiting centers. The distribution of the subtypes was as follows: 1,714 HR1 HER22 (56.0%), 414 HR1 HER21 (13.5%), 423 HR2 HER21 (13.9%) and 507 HR2 HER22 (16.6%) patients with breast cancer. There were significant differences in age, menopausal status, age at menarche, number of children, age at first full-term pregnancy (FFTP), duration of breastfeeding and duration of endogenous estrogen exposure between tumor subtypes (p < 0.05). Compared to HR1 HER22 patients, the other subtype patients showed more frequency in having more numbers of children and less frequency in having earlier menarche, later FFTP and longer endogenous estrogen exposure. Although HR2 HER21 patients were less obese, HR2 HER22 patients were younger and more obese. In conclusion, age, body mass index and reproductive factors were differentially associated with breast tumor subtypes suggesting a possible distinct etiology for tumor progression.Breast cancer is a heterogeneous disease in terms of clinical behavior. Breast tumors have been classified into intrinsic subtypes using gene expression patterns measured by microarrays.1-3 The intrinsic subtypes were explained as the clinicopathological definition based on the expression of estrogen and progesterone receptors (ER and PR), human epidermal growth factor receptor 2 (HER2) and For the basallike subtype of breast cancer, epidermal growth factor receptor (EGFR) and cytokeratin 5/6 (CK 5/6) were also used as surrogates.5 These tumor subtypes have shown significant differences in their clinical features. 2,3,6 Notwithstanding the clinical heterogeneity of the tumor subtype, the etiological heterogeneity has not been established.7 Through previous epidemiological studies, several reproductive factors, such as early menarche, late menopause and late age at first full-term pregnancy (FFTP), and family history have been established as risk factors of breast cancer, and obesity has been probable as protective or a risk factor of breast cancer depending on the menopausal status. [8][9][10] Furthermore, well-known risk factors of breast cancer have been associated with the ER-positive subtype rather than the ER-negative subtype.

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Population-based estimates of the relation between breast cancer risk, tumor subtype, and family history

Cited by 23 publications

References 32 publications

Family History of Cancer in Relation to Breast Cancer Subtypes in African American Women

Family History of Cancer in Relation to Breast Cancer Subtypes in African American Women

Family History, Mammographic Density, and Risk of Breast Cancer

Heterogeneity of epidemiological factors by breast tumor subtypes in Korean women: A case-case study

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