Population-Based Estimates of the Occurrence of Multiple vs First Primary Basal Cell Carcinomas in 4 European Regions

Abstract

To estimate the population-based incidence of first and multiple basal cell carcinomas (BCCs) throughout Europe.Design: The registry practices of 4 population-based cancer registries that routinely register BCC incidence were evaluated for inclusion of first and subsequent histologically confirmed BCCs. Where multiple BCCs were not routinely registered, comparisons with hospital databases were made.Data Sources: Cancer registry databases from Finland, Malta, the Netherlands (Eindhoven), and Scotland were inspected for registry of first and multiple BCCs in recent years. Cross-checks with hospital and pathology databases were made to check for completeness.Results: Age-standardized first BCC incidence rates varied between 77 (Malta) and 158 (Eindhoven) per 100 000 person-years. Generally, rates were higher in males than in females, and incidences increased steeply with increasing age. There were approximately 30% more patients with a BCC and 40% to 100% more BCC tumors diagnosed in a given calendar year than were routinely reported for patients with a first primary BCC. The difference between the number of first primary BCCs and the total number of BCCs in a calendar year was generally slightly higher for males than for females and increased substantially with increasing age. Conclusion:Currently, routinely reported first BCC incidence rates of the included countries should be multiplied by a factor of 1.3 for an estimate of total number of patients diagnosed as having a BCC in a given year.

Incidence of lentigo maligna in Olmsted County, Minnesota, 1970 to 2007

“…During the same study period, we found a higher incidence of LM and also a steady increase in the incidence rate among men and women between 50 and 70 years of age. For another perspective, the overall incidence of LM in our study was 6.3 per 100,000 person-years, whereas in 4 European population-based studies, the incidence of new patients with basal cell carcinoma ranged from 77 to 158 per 100,000 person-years (11). …”

The patient journey: a report of skin cancer care across Europe

“…The EPIDERM project investigating skin cancers across Europe 13 has identified and confirmed variations in skin cancer incidence 14,15 and treatment 16 that exist between the participating centres. These variations may be attributed to inherent differences in the populations under study (for example skin colour, dietary variations, sun exposure practices etc.)…”

Expression of CXCR4 Is Associated with Progression and Invasion in Patients with Nasal-Surface Basal Cell Carcinoma

“…In addition, the incidence of BCC appears to be increasing worldwide [1,2,26]. With an aging society, longevity of the general population is thought to be the major cause of the increasing incidence of this cancer.…”

“…Basal cell carcinoma (BCC) is the most common skin cancer with an increasing incidence worldwide, especially in Europe and Australia [1,2]. The major cause of BCC is a combination of cumulative ultraviolet light exposure or occasional intense ultraviolet exposure and overexposure to X-rays or other forms of radiation [3].…”