Population-based Borrelia burgdorferi sensu lato seroprevalence and associated risk factors in Finland

Beek, Janko van; Sajanti, Eeva; Helve, Otto; Ollgren, Jukka; Virtanen, Mikko; Rissanen, Harri; Lyytikäinen, Outi; Hytönen, Jukka; Sane, Jussi

doi:10.1016/j.ttbdis.2017.10.018

Cited by 28 publications

(29 citation statements)

References 26 publications

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“…We report the LB seroprevalence in Finland in 1968e72 to be 20.0%. The overall seroprevalence in the 1970s was five times higher than in our recent seroprevalence study from 2011 with a seroprevalence estimate of 3.9% [20]. The results of these two seroprevalence studies are not fully comparable, as only adults >29 years were included in the study from 2011 [20].…”

Section: Discussioncontrasting

confidence: 55%

“…In this study, we report the results of LB seroprevalence among the general population in Finland during the years 1968e1972, and of the related risk factors using serum samples and background data collected during a cross-sectional nationwide study. The results of this study are discussed in relation to the seroprevalence results of samples from 2011 [20], shedding light on the LB seroprevalence in Europe 50 years ago.…”

Section: Introductionmentioning

confidence: 91%

“…The IgG antibodies in serum samples towards Borrelia WCS were measured as described previously [20]. Briefly, serum samples (1:100) were allowed to adhere to wells coated with sonicate of B. burgdorferi ss B31.…”

Section: Borrelia Whole-cell Sonicate Igg Elisamentioning

confidence: 99%

“…The antibodies in the screening-positive samples towards the synthetic C6 peptide were measured according to protocol of the manufacturer and as described previously [20].The samples that were C6-positive (LI 0.9) or C6-negative (LI < 0.9, but with WCS IgG result 40 EIU) were analysed with recomBead IgG 2.0 (Mikrogen) as described previously [20]. Briefly, magnetic polystyrene beads (MagPlex beads) For an additional sample quality check, 50 samples negative in the Borrelia WCS ELISA test were analysed with recomBead IgG 2.0 as described above.…”

Section: C6 Lyme Elisa and Recombead Igg 20mentioning

confidence: 99%

“…Furthermore, in selected groups of people with outdoor activities, such as forestry workers, farmers, and orienteers [13e17], and in residents of highly endemic geographical areas [18,19], LB seroprevalence can be as high as 20%. In our recent study using the same serological algorithm, the LB seroprevalence among the general population in Finland in 2011 was estimated as 3.9% [20].…”

Section: Introductionmentioning

confidence: 99%

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Seroprevalence of Lyme borreliosis in Finland 50 years ago

Cuellar

Dub

Sane

et al. 2020

Clinical Microbiology and Infection

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Editor: S.J. Cutler Keywords:Europe Lyme borreliosis Seroprevalence historical risk factors a b s t r a c t Objectives: Lyme borreliosis (LB) is a tick-borne infection common in Europe. In Finland, the LB seroprevalence in the healthy population was 3.9% in 2011. While the present-day seroprevalence of LB is well characterized in several European areas, there are no studies on the seroprevalence of LB before the description of the infection in the late 1970s. Methods: We used a subset of historical serum samples (n ¼ 994) collected during the Finnish Mobile Clinic Health Survey, a nationwide cross-sectional health survey of the 1960s and 1970s. All samples were screened with Borrelia burgdorferi whole-cell sonicate IgG ELISA. The seropositivity of the samples was further confirmed by the C6 peptide ELISA and recomBead IgG 2.0 bead immunoassay. The association of LB seropositivity with risk factors and with self-reported diseases and symptoms relating to disseminated LB were analysed by logistic regression. Results: B. burgdorferi IgGs were detected in 199 of 994 analysed samples; hence, the overall seroprevalence was 20.0% (95% confidence interval: 17.6e22.6). The highest seroprevalence was observed in persons aged 50 years (165/696), in those currently not working (92/383), and in the regions of South and Central Finland (91/226 and 27/88, respectively). Further, perception of feeling unhealthy (129/197 versus 412/794) was higher among LB-seropositive individuals compared to LB-seronegative participants. Conclusion: LB seroprevalence was considerably higher in Finland in the late 1960s and early 1970s than in 2011. This result questions the perception of an unprecedentedly high LB seroprevalence in presentday Europe.

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Section: Discussioncontrasting

confidence: 55%

Section: Introductionmentioning

confidence: 91%

Section: Borrelia Whole-cell Sonicate Igg Elisamentioning

confidence: 99%

Section: C6 Lyme Elisa and Recombead Igg 20mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Seroprevalence of Lyme borreliosis in Finland 50 years ago

Cuellar

Dub

Sane

et al. 2020

Clinical Microbiology and Infection

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Association of Seropositivity to Borrelia burgdorferi With the Risk of Neuropsychiatric Disorders and Functional Decline in Older Adults

et al. 2020

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IMPORTANCE Exposure to Borrelia burgdorferi (Bb) has been reported to be associated with certain neuropsychiatric disorders. OBJECTIVE To establish the association between seropositivity to Bb and incidental neuropsychiatric disorders (eg, cognitive decline, incident dementia, and depressive symptoms) as well as functional decline. DESIGN, SETTING, AND PARTICIPANTS This prospective, 6-year follow-up cohort study was conducted in a rural southwestern region of France and included 689 retired farmers 65 years or older randomly recruited from the Farmer Health Insurance System who agreed to submit a blood sample and were participants in the Aging Multidisciplinary Investigation study, an ongoing epidemiological prospective study of aging initiated in 2007. The data were analyzed from April to May 2019. EXPOSURES Borrelia burgdorferi serology testing was performed in a 2-tiered approach. During the follow-up period, cognitive decline, incident dementia, depressive symptoms, and functional decline were repeatedly assessed. MAIN OUTCOMES AND MEASURES Diagnosis of dementia relied on a 3-step procedure; cognitive decline was determined using the Mini-Mental State Examination and depressive symptomatology was assessed using the Center for Epidemiologic Studies Depression scale. For disability, scores on instrumental and basic activities of daily living were investigated. RESULTS Of 689 participants, 432 (62.2%) were men and the mean (SD) age was 75.8 (6.4) years. The seroprevalence rate of Bb was 6.5%. At baseline, compared with Bb− participants, those who were Bb+ were older, predominantly men, and had lower depressive symptoms. No association between seropositivity and any of the studied outcomes (ie, cognitive decline, depressive symptoms, or functional decline) was found in the crude analysis and after adjusting for confounding variables. Regarding incident dementia, no increased risk was found among Bb+ participants (hazard ratio, 0.42; 95% CI, 0.1-1.17; adjusted for diverse confounders). CONCLUSIONS AND RELEVANCE To our knowledge, this is one of the few longitudinal studies exploring the risk of neuropsychiatric disorders and functional decline associated with exposure to Bb. Despite its limitations (eg, a lack of information if clinical manifestations of Lyme borreliosis existed, date of exposure, or treatment received), this study suggests that seropositivity to Bb is not a risk factor for incidental neuropsychiatric disorders and functional decline.

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Public Health Aspects of Lyme Borreliosis: The German Experience

Wilking

Stark

2022

Lyme Borreliosis

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Population-based Borrelia burgdorferi sensu lato seroprevalence and associated risk factors in Finland

Cited by 28 publications

References 26 publications

Seroprevalence of Lyme borreliosis in Finland 50 years ago

Seroprevalence of Lyme borreliosis in Finland 50 years ago

Association of Seropositivity to Borrelia burgdorferi With the Risk of Neuropsychiatric Disorders and Functional Decline in Older Adults

Public Health Aspects of Lyme Borreliosis: The German Experience

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