Population‐based assessment of risks for severe COVID‐19 disease outcomes

Zerbo, Ousseny; Lewis, Ned; Fireman, Bruce; Goddard, Kristin; Skarbinski, Jacek; Sejvar, James J.; Azziz‐Baumgartner, Eduardo; Klein, Nicola P.

doi:10.1111/irv.12901

Cited by 25 publications

(22 citation statements)

References 18 publications

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“…After evaluating and assessing as much as 257 potential studies, 201 studies were removed due to outcome of interest being not available. In the end, what underlay this meta-analysis were eligible fifty-six articles with 426,261 COVID-19 patients [5] , [6] , [7] , [8] , [9] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] . The detail of selection process is shown by a chart flow in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

“…Taken together, those urged us to investigate the association between asthma and COVID-19 mortality in a specific country or region. To date, a number of individual studies have explored the association between asthma and COVID-19 mortality in the United States with conflicting results [5] , [6] , [7] , [8] , [9] , but no quantitative meta-analysis on this topic was conducted to address this issue. Therefore, we performed a quantitative meta-analysis to investigate the impact of asthma on the risk for COVID-19 mortality in the United States.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of asthma on COVID-19 mortality in the United States: Evidence based on a meta-analysis

Han

Hou

et al. 2022

International Immunopharmacology

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impact of asthma on COVID-19 mortality in the United States: Evidence based on a meta-analysis

Han

Hou

et al. 2022

International Immunopharmacology

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“…The COVID-19 pandemic in the U.S. has disproportionately impacted communities of color with substantially higher rates of infection, hospitalization, and death documented in Asian, Black, and Hispanic people compared to White people ( 1 ). In addition, the pandemic has exacerbated deep-seated social and economic disparities related to living conditions and work environments ( 2 ) putting communities of color at heightened risk of COVID-19-related stressors and adverse mental heath outcomes.…”

Section: Introductionmentioning

confidence: 99%

Contributions of COVID-19 Pandemic-Related Stressors to Racial and Ethnic Disparities in Mental Health During Pregnancy

et al. 2022

Self Cite

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BackgroundThis study aimed to identify racial and ethnic disparities in prenatal mental health and identify COVID-19 pandemic-related health/healthcare and economic contributors to these disparities, using an established framework for disparity investigation.MethodsThis cross-sectional study includes 10,930 pregnant people at Kaiser Permanente Northern California who completed an online survey between June 22, 2020 and April 28, 2021 on COVID-19 pandemic-related health/healthcare and economic stressors, depression, and anxiety. Self-reported race and ethnicity were extracted from electronic health records. Weighted analyses were used to evaluate the association between racial and ethnic category and prenatal depression and anxiety; the prevalence of each stressor by race and ethnicity; and the relationship between each stressor and prenatal depression and anxiety in each racial and ethnic category.ResultsThe sample was 22% Asian, 3% Black, 20% Hispanic, 5% Other/Multiracial/Unknown, and 49% White. Compared to White people, Black and Hispanic people had a higher prevalence of prenatal depression (aPR: 1.85, 95% CI: 1.45, 2.35 and aPR: 1.17, 95% CI: 1.00, 1.37, respectively) and anxiety (aPR: 1.71, 95% CI: 1.34, 2.18 and aPR: 1.10, 95% CI: 0.94, 1.29, respectively). Compared to White people, Black and Hispanic people had a higher prevalence of moderate/severe distress due to changes in prenatal care (24 vs. 34 and 31%), and food insecurity (9 vs. 31 and 24%). Among Black and Hispanic people, distress due to changes in prenatal care was associated with a greater prevalence of prenatal depression (aPR: 2.27, 95% CI: 1.41, 3.64 and aPR: 2.76, 95% CI: 2.12, 3.58, respectively) and prenatal anxiety (aPR: 3.00, 95% CI: 1.85, 4.84 and aPR: 2.82, 95% CI: 2.15, 3.71, respectively). Additionally, among Hispanic people, high-risk employment and food insecurity were associated with a greater prevalence of prenatal depression and anxiety.ConclusionsThis study identified racial and ethnic disparities in mental health for pregnant Black and Hispanic people. Distress due to prenatal care changes contributed to the observed disparities in prenatal depression and anxiety for Black and Hispanic people and food insecurity additionally contributed to the observed disparities for Hispanic people. Addressing distress due to changes to prenatal care and food insecurity specifically in Black and Hispanic people may help reduce the high burden of poor mental health and reduce observed disparities in these communities.

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“…Several studies investigated factors associated with severe COVID-19 outcomes that can be either environmental, population based, or genetic. For instance, a geographic and population variation in the disease course and outcome has demonstrated that individuals representing Black, Hispanic, or Asian ethnicities have a higher risk of death compared to Caucasians [ 2 , 3 ]. The identified risk factors of COVID-19 infection are advanced age, male sex, and comorbidities (especially: renal disease, oncological pathologies, chronic respiratory disease, and cardiovascular disease—excluding hypertension and dementia), but they do not fully explain the wide spectrum of disease manifestations [ 2 , 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…For instance, a geographic and population variation in the disease course and outcome has demonstrated that individuals representing Black, Hispanic, or Asian ethnicities have a higher risk of death compared to Caucasians [ 2 , 3 ]. The identified risk factors of COVID-19 infection are advanced age, male sex, and comorbidities (especially: renal disease, oncological pathologies, chronic respiratory disease, and cardiovascular disease—excluding hypertension and dementia), but they do not fully explain the wide spectrum of disease manifestations [ 2 , 4 , 5 , 6 ]. Moreover, the viral load can play a role in the COVID-19 severity, as demonstrated for mortality, especially in combination with advanced age [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Beyond GWAS—Could Genetic Differentiation within the Allograft Rejection Pathway Shape Natural Immunity to COVID-19?

Szyda

Dobosz

Stojak

et al. 2022

IJMS

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COVID-19 infections pose a serious global health concern so it is crucial to identify the biomarkers for the susceptibility to and resistance against this disease that could help in a rapid risk assessment and reliable decisions being made on patients’ treatment and their potential hospitalisation. Several studies investigated the factors associated with severe COVID-19 outcomes that can be either environmental, population based, or genetic. It was demonstrated that the genetics of the host plays an important role in the various immune responses and, therefore, there are different clinical presentations of COVID-19 infection. In this study, we aimed to use variant descriptive statistics from GWAS (Genome-Wide Association Study) and variant genomic annotations to identify metabolic pathways that are associated with a severe COVID-19 infection as well as pathways related to resistance to COVID-19. For this purpose, we applied a custom-designed mixed linear model implemented into custom-written software. Our analysis of more than 12.5 million SNPs did not indicate any pathway that was significant for a severe COVID-19 infection. However, the Allograft rejection pathway (hsa05330) was significant (p = 0.01087) for resistance to the infection. The majority of the 27 SNP marking genes constituting the Allograft rejection pathway were located on chromosome 6 (19 SNPs) and the remainder were mapped to chromosomes 2, 3, 10, 12, 20, and X. This pathway comprises several immune system components crucial for the self versus non-self recognition, but also the components of antiviral immunity. Our study demonstrated that not only single variants are important for resistance to COVID-19, but also the cumulative impact of several SNPs within the same pathway matters.

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Population‐based assessment of risks for severe COVID‐19 disease outcomes

Cited by 25 publications

References 18 publications

Impact of asthma on COVID-19 mortality in the United States: Evidence based on a meta-analysis

Impact of asthma on COVID-19 mortality in the United States: Evidence based on a meta-analysis

Contributions of COVID-19 Pandemic-Related Stressors to Racial and Ethnic Disparities in Mental Health During Pregnancy

Beyond GWAS—Could Genetic Differentiation within the Allograft Rejection Pathway Shape Natural Immunity to COVID-19?

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