Population-Based Analysis of Invasive Fungal Infections, France, 2001–2010

Bitar, Dounia; Lortholary, Olivier; Strat, Yann Le; Nicolau, J.; Coignard, B.; Tattevin, Pierre; Che, Didier; Dromer, Françoise

doi:10.3201/eid2007.140087

Cited by 344 publications

(308 citation statements)

References 32 publications

(32 reference statements)

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“…This disease is associated with significant morbidity and carries a crude mortality rate of up to 30-40% in some risk groups. [6][7][8] In addition, a growing number of azole-resistant A. fumigatus strains has been identified in Europe over the past decade, contributing significantly to treatment failure. [9][10][11][12][13] Preclinical in vivo studies are indispensable for gaining a better understanding of the pathogenesis of infections caused by both azole-susceptible and -resistant strains and for assessing their response to antifungal drugs.…”

mentioning

confidence: 99%

Longitudinal, in vivo assessment of invasive pulmonary aspergillosis in mice by computed tomography and magnetic resonance imaging

Poelmans

Hillen

Vanherp

et al. 2016

Laboratory Investigation

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Invasive aspergillosis is an emerging threat to public health due to the increasing use of immune suppressive drugs and the emergence of resistance against antifungal drugs. To deal with this threat, research on experimental disease models provides insight into the pathogenesis of infections caused by susceptible and resistant Aspergillus strains and by assessing their response to antifungal drugs. However, standard techniques used to evaluate infection in a preclinical setting are severely limited by their invasive character, thereby precluding evaluation of disease extent and therapy effects in the same animal. To enable non-invasive, longitudinal monitoring of invasive pulmonary aspergillosis in mice, we optimized computed tomography (CT) and magnetic resonance imaging (MRI) techniques for daily follow-up of neutropenic BALB/c mice intranasally infected with A. fumigatus spores. Based on the images, lung parameters (signal intensity, lung tissue volume and total lung volume) were quantified to obtain objective information on disease onset, progression and extent for each animal individually. Fungal lung lesions present in infected animals were successfully visualized and quantified by both CT and MRI. By using an advanced MR pulse sequence with ultrashort echo times, pathological changes within the infected lung became visually and quantitatively detectable at earlier disease stages, thereby providing valuable information on disease onset and progression with high sensitivity. In conclusion, these noninvasive imaging techniques prove to be valuable tools for the longitudinal evaluation of dynamic disease-related changes and differences in disease severity in individual animals that might be readily applied for rapid and cost-efficient drug screening in preclinical models in vivo.

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confidence: 99%

Longitudinal, in vivo assessment of invasive pulmonary aspergillosis in mice by computed tomography and magnetic resonance imaging

Poelmans

Hillen

Vanherp

et al. 2016

Laboratory Investigation

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“…Owing to an evolving fungal epidemiology and the emergence of drug‐resistant strains,1, 3, 4 a versatile antifungal armamentarium is required to meet this challenge.…”

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confidence: 99%

Pharmacokinetic and Pharmacodynamic Evaluation of the Drug‐Drug Interaction Between Isavuconazole and Warfarin in Healthy Subjects

Desai

Yamazaki

Dietz

et al. 2016

Clinical Pharm in Drug Dev

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This phase 1 trial evaluated pharmacokinetic and pharmacodynamic interactions between the novel triazole antifungal agent isavuconazole and warfarin in healthy adults. Multiple doses of isavuconazole were administered as the oral prodrug, isavuconazonium sulfate (372 mg 3 times a day for 2 days loading dose, then 372 mg once daily thereafter; equivalent to isavuconazole 200 mg), in the presence and absence of single doses of oral warfarin sodium 20 mg. Coadministration with isavuconazole increased the mean area under the plasma concentration‐time curves from time 0 to infinity of S‐ and R‐warfarin by 11% and 20%, respectively, but decreased the mean maximum plasma concentrations of S‐ and R‐warfarin by 12% and 7%, respectively, relative to warfarin alone. Mean area under the international normalized ratio curve and maximum international normalized ratio were 4% lower in the presence vs absence of isavuconazole. Mean warfarin area under the prothrombin time curve and maximum prothrombin time were 3% lower in the presence vs absence of isavuconazole. There were no serious treatment‐emergent adverse events (TEAEs), and no subjects discontinued the study due to TEAEs. All TEAEs were mild in intensity. These findings indicate that coadministration with isavuconazole has no clinically relevant effects on warfarin pharmacokinetics or pharmacodynamics.

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“…Ces différents agents fongiques sont susceptibles d'augmenter la mortalité et la morbidité des patients [8][9][10] ; (3) les traitements antibiotiques pourraient faciliter le développement des infections fongiques pulmonaires chez ces patients. De même, l'utilisation de traitements immunosuppresseurs (corticosté-roïdes au long cours ou autres) favorise le développement d'infections fongiques invasives et graves, en particulier dans un contexte de transplantation, mais éga-lement sur fond de pathologie chronique telle que la BPCO où des cas d'aspergillose semi-invasive ont été rapportés [11][12][13] ; (4) enfin, les champignons sont capables d'interagir notamment avec des bactéries [14]. Ils peuvent aussi former des biofilms et induire une résistance aux traitements anti-infectieux.…”

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Nguyen

Delhaès

2015

Med Sci (Paris)

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Population-Based Analysis of Invasive Fungal Infections, France, 2001–2010

Abstract: These infections are underrecognized as a cause of death in the general population and high-risk groups.

Cited by 344 publications

References 32 publications

Longitudinal, in vivo assessment of invasive pulmonary aspergillosis in mice by computed tomography and magnetic resonance imaging

Longitudinal, in vivo assessment of invasive pulmonary aspergillosis in mice by computed tomography and magnetic resonance imaging

Pharmacokinetic and Pharmacodynamic Evaluation of the Drug‐Drug Interaction Between Isavuconazole and Warfarin in Healthy Subjects

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