Populatieverschillen in de volledigheid en betrouwbaarheid van COVID-19-registratiedata

Deursen, Babette van; Jonge, Ester A.L. de

doi:10.1007/s12508-022-00358-7

Cited by 1 publication

(2 citation statements)

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“…29 Also, due to asymptomatic infections and limited testing capacity in the beginning of the pandemic, a substantial number of infections remained undetected. 30,31 Therefore, further research is needed to determine the role of SARS-CoV-2 infection in the association between COVID-19 vaccination and miscarriage.…”

Section: Discussionmentioning

confidence: 99%

“…However, a SARS‐CoV‐2 infection could also lead to delayed COVID‐19 vaccination, as people had to wait at least 3 months after a SARS‐CoV‐2 infection before they could get vaccinated 29 . Also, due to asymptomatic infections and limited testing capacity in the beginning of the pandemic, a substantial number of infections remained undetected 30,31 . Therefore, further research is needed to determine the role of SARS‐CoV‐2 infection in the association between COVID‐19 vaccination and miscarriage.…”

Section: Discussionmentioning

confidence: 99%

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The risk of miscarriage after COVID‐19 vaccination before and during pregnancy

de Feijter,

van Gelder,

Vissers

et al. 2023

Pharmacoepidemiology and Drug

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PurposePregnant women are at higher risk of severe illness and adverse pregnancy outcomes due to a SARS‐CoV‐2 infection, which can be prevented by vaccination. Observational studies are needed to ascertain the safety of COVID‐19 vaccination during pregnancy. We aimed to determine whether COVID‐19 vaccination before and during pregnancy is associated with the risk of miscarriage.MethodsIn this cohort study, we included 4640 pregnant women (mean age: 32.8 ± 3.7 years) from the Dutch Pregnancy Drug Register between February 2021 and August 2022. Information on COVID‐19 vaccinations, miscarriage, and confounders was self‐reported, using web‐based questionnaires. The hazard ratio (HR) of miscarriage (in gestational weeks 6–20) after a COVID‐19 vaccination, was estimated using the survival analyses. A COVID‐19 vaccination during pregnancy (≥1 COVID‐19 vaccination between week 2 and 20 of pregnancy) was included as a time‐dependent exposure and vaccination prior to pregnancy was included as a binary exposure.ResultsA total of 3202 pregnant women (69%) received ≥1 COVID‐19 vaccine in gestational week 2–20. We observed no association of vaccination during pregnancy with the risk of miscarriage (adjusted HR = 1.29, 95% CI = 0.93–1.74). Vaccination prior to pregnancy, however, was associated with a decreased risk of miscarriage (adjusted HR = 0.69, 95% CI = 0.48–0.99).ConclusionsWe demonstrated that COVID‐19 vaccination during pregnancy is not associated with an increased risk of miscarriage in gestational weeks 6–20. This study adds to the growing body of evidence demonstrating the safety of COVID‐19 vaccination during pregnancy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%