Popular Fancies in Table Ware

Role of Thromboxane A2 Receptor on the Effects of Oxidized LDL on Microvascular Endothelium Nitric Oxide, Endothelin‐1, and IL‐6 Production

“…However, other mechanisms could be involved, since both modified apolipoprotein B and lipid moieties, such as isoprostanes, present in oxidized LDL can interact with other receptors present in endothelial cells, such as the scavenger receptor [38] or the thromboxane A 2 receptor (TP) [31]. While in human endothelial cells the role of TP receptors in modulating angiogenesis, apoptosis, and adhesion molecule expression is well established [3,20], whether they participate in the control of the synthesis of vasoactive products is largely unknown. The interaction between isoprostanes and the endothelium is relevant because these molecules, which are normally present on the surface of oxidized LDL particles, are also produced by cells exposed to oxidative stress [27].…”