“…In contrast, GENS at 200 mg/kg/day almost completely suppressed the expression of C/EBPα and PPARγ protein. This result is consistent with recent research, thereby suggesting that the consumption of edible seaweed GENS may result in a lower weight gain through the inhibition of adipose tissue development [19]. …”
Section: Resultssupporting
confidence: 93%
“…In particular, Gelidium elegans (GENS), previously known as Gelidium amansii , has been shown to have nutraceutical activities such as anti-adipogenesis and anti-obesity effects [19,20,21]. However, the mechanism by which GENS is able to achieve its anti-obesity effects remains to be clearly defined.…”
The incidence of obesity is rising at an alarming rate throughout the world and is becoming a major public health concern with incalculable social and economic costs. Gelidium elegans (GENS), also previously known as Gelidium amansii, has been shown to exhibit anti-obesity effects. Nevertheless, the mechanism by which GENS is able to do this remains unclear. In the present study, our results showed that GENS prevents high-fat diet (HFD)-induced weight gain through modulation of the adenosine monophosphate-activated protein kinase (AMPK)-PR domain-containing16 (PRDM16)-uncoupling protein-1 (UCP-1) pathway in a mice model. We also found that GENS decreased hyperglycemia in mice that had been fed a HFD compared to corresponding controls. We also assessed the beneficial effect of the combined treatment with GENS and orlistat (a Food and Drug Administration-approved obesity drug) on obesity characteristics in HFD-fed mice. We found that in HFD-fed mice, the combination of GENS and orlistat is associated with more significant weight loss than orlistat treatment alone. Moreover, our results demonstrated a positive synergistic effect of GENS and orlistat on hyperglycemia and plasma triglyceride level in these animals. Thus, we suggest that a combination therapy of GENS and orlistat may positively influence obesity-related health outcomes in a diet-induced obese population.
“…In contrast, GENS at 200 mg/kg/day almost completely suppressed the expression of C/EBPα and PPARγ protein. This result is consistent with recent research, thereby suggesting that the consumption of edible seaweed GENS may result in a lower weight gain through the inhibition of adipose tissue development [19]. …”
Section: Resultssupporting
confidence: 93%
“…In particular, Gelidium elegans (GENS), previously known as Gelidium amansii , has been shown to have nutraceutical activities such as anti-adipogenesis and anti-obesity effects [19,20,21]. However, the mechanism by which GENS is able to achieve its anti-obesity effects remains to be clearly defined.…”
The incidence of obesity is rising at an alarming rate throughout the world and is becoming a major public health concern with incalculable social and economic costs. Gelidium elegans (GENS), also previously known as Gelidium amansii, has been shown to exhibit anti-obesity effects. Nevertheless, the mechanism by which GENS is able to do this remains unclear. In the present study, our results showed that GENS prevents high-fat diet (HFD)-induced weight gain through modulation of the adenosine monophosphate-activated protein kinase (AMPK)-PR domain-containing16 (PRDM16)-uncoupling protein-1 (UCP-1) pathway in a mice model. We also found that GENS decreased hyperglycemia in mice that had been fed a HFD compared to corresponding controls. We also assessed the beneficial effect of the combined treatment with GENS and orlistat (a Food and Drug Administration-approved obesity drug) on obesity characteristics in HFD-fed mice. We found that in HFD-fed mice, the combination of GENS and orlistat is associated with more significant weight loss than orlistat treatment alone. Moreover, our results demonstrated a positive synergistic effect of GENS and orlistat on hyperglycemia and plasma triglyceride level in these animals. Thus, we suggest that a combination therapy of GENS and orlistat may positively influence obesity-related health outcomes in a diet-induced obese population.
“…However, the reported side effects of these drugs include tension headaches, thirst, insomnia, constipation, and steatorrhea [7,8]. Consequently, many researchers have focused intensively on the identification of natural substances to treat obesity-related effects.…”
Seaweed, a popular and abundant food ingredient mainly consumed in Asian countries, is a good source of bioactive compounds with anti-obesity effects. However, the anti-obesity effects of Sargassum thunbergii have not yet been established. In this study, we isolated six indole derivatives (STCs)—indole-2-carboxaldehyde (STC-1), indole-3-carboxaldehyde (STC-2), indole-4-carboxaldehyde (STC-3), indole-5-carboxaldehyde (STC-4), indole-6-carboxaldehyde (STC-5), and indole-7-carboxaldehyde (STC-6)—from S. thunbergii and evaluated their inhibitory effects on adipocyte differentiation in 3T3-L1 cells. We found that STC-1 and STC-5 resulted in non-toxic inhibition of the differentiation of 3T3-L1 adipocytes and thus selected these compounds for further study. STC-1 and STC-5 significantly inhibited lipid accumulation and downregulated the expression of peroxisome proliferator-activated receptor-γ (PPARγ), CCAAT/enhancer-binding protein α (C/EBPα), and sterol regulatory element-binding protein 1c (SREBP-1c) in a dose-dependent manner. The specific mechanism mediating the effects of STC-1 and STC-5 was shown to be AMP-activated protein kinase (AMPK) activation. Our results demonstrated the inhibitory effect of STC-1 and STC-5 on adipogenesis through the activation of the AMPK signal pathway. Together, these findings suggested that STC-1 and STC-5 may be effective candidates for the prevention of obesity or obesity-related diseases.
“…For instance, Kang et al (2016) assessed the anti-obesity effects of ethanol extracts from seaweeds collected from Jeju Island, Korea [23]. Of the extracts tested, the extract from the red seaweed Plocamium telfairiae was found to have the highest inhibitory effect on lipogenesis in adipocytes, especially in decreasing the expression of the adipogenic-specific proteins peroxisome proliferator-activated receptor-γ (PPAR-γ), cytosine-cytosine-adenosine-adenosine-thymidine (CCAAT)/enhancer-binding protein-α (C/EBPα), sterol regulatory element-binding protein 1 (SREBP 1), and fatty acid-binding protein 4.…”
Section: Seaweeds As Food and Their Potential Anti-obesity Effectsmentioning
confidence: 99%
“…Of the extracts tested, the extract from the red seaweed Plocamium telfairiae was found to have the highest inhibitory effect on lipogenesis in adipocytes, especially in decreasing the expression of the adipogenic-specific proteins peroxisome proliferator-activated receptor-γ (PPAR-γ), cytosine-cytosine-adenosine-adenosine-thymidine (CCAAT)/enhancer-binding protein-α (C/EBPα), sterol regulatory element-binding protein 1 (SREBP 1), and fatty acid-binding protein 4. In another study, administration of extracts from the edible red seaweed Gelidium amansii caused body weight reduction in mice fed a high-fat diet [23]. The effect was attributed to suppressed adipogenic expression in adipocytes.…”
Section: Seaweeds As Food and Their Potential Anti-obesity Effectsmentioning
Obesity is a major epidemic that poses a worldwide threat to human health, as it is also associated with metabolic syndrome, type 2 diabetes and cardiovascular disease. Therapeutic intervention through weight loss drugs, accompanied by diet and exercise, is one of the options for the treatment and management of obesity. However, the only approved anti-obesity drug currently available in the market is orlistat, a synthetic inhibitor of pancreatic lipase. Other anti-obesity drugs are still being evaluated at different stages of clinical trials, while some have been withdrawn due to their severe adverse effects. Thus, there is a need to look for new anti-obesity agents, especially from biological sources. Marine algae, especially seaweeds are a promising source of anti-obesity agents. Four major bioactive compounds from seaweeds which have the potential as anti-obesity agents are fucoxanthin, alginates, fucoidans and phlorotannins. The anti-obesity effects of such compounds are due to several mechanisms, which include the inhibition of lipid absorption and metabolism (e.g., fucoxanthin and fucoidans), effect on satiety feeling (e.g., alginates), and inhibition of adipocyte differentiation (e.g., fucoxanthin). Further studies, especially testing bioactive compounds in long-term human trials are required before any new anti-obesity drugs based on algal products can be developed.
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