POPd/TBAB co-catalyzed Suzuki cross-coupling reaction of heteroaryl chlorides/bromides with 4-fluorophenylboronic acid in water

Scope and limitation of propylene carbonate as a sustainable solvent in the Suzuki–Miyaura reaction

“…Aer 3 h reaction time, product 16 [58][59][60] was formed only in an acceptable average yield of 51% by oil heating and 57% average yield under MW conditions. 4-(4-Fluorophenyl)pyridine [61][62][63] (17) was obtained with a 75% average yield by traditional heating in 1 h and 82% average yield under microwave irradiation. From this results we conclude that, in the same reaction time, reactions conducted under microwave irradiation afford higher yields, than those for oil-heating experiments.…”

Tetrabutylammonium Bromide (TBAB) Catalyzed Synthesis of Bioactive Heterocycles

“…It showed excellent catalytic efficacies for the synthesis of N -aryl amines [ 31 ] and 1-alkyl/aryl-2-(1-arylsulfonyl alkyl) benzimidazoles [ 32 ]. It was also employed for the carbonylation-peroxidation of styrene derivatives [ 33 ], the alkylation of aldehydes or ketones [ 34 ], the S -alkylation of 4-mercapto-6-methyl-2-pyrone [ 35 ], the N- alkylation of acridones [ 36 ], the sulfonylation of para -quinone methides [ 37 ], Suzuki cross-coupling reaction [ 38 ], Heck reaction [ 39 ], and Suzuki–Miyaura reaction [ 40 ].…”