Poorly differentiated oncocytic thyroid carcinoma – diagnostic implications and outcome

Dettmer, Matthias S.; Schmitt, Anja; Steinert, H.; Moch, Holger; Komminoth, Paul; Perren, Aurel

doi:10.1111/j.1365-2559.2012.04188.x

Cited by 53 publications

(37 citation statements)

References 33 publications

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“…PDs can be admixed with well differentiated thyroid tumors like PTCs or FTCs but even a small PD component determines the patient outcome (Dettmer, et al 2011). Oncocytic PD were originally not included in the consensus proposal, however it was shown that proposed criteria were also applicable to them, demonstrating an even worse outcome for oncocytic PD compared to conventional PD (Dettmer, et al 2012). …”

Section: Introductionmentioning

confidence: 99%

MicroRNA profile of poorly differentiated thyroid carcinomas: new diagnostic and prognostic insights

Dettmer¹,

Perren²,

Moch³

et al. 2014

Journal of Molecular Endocrinology

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The diagnosis of conventional and oncocytic poorly differentiated thyroid carcinomas is difficult. The aim of this study was to characterize their largely unknown miRNA expression profile and to compare it to well differentiated thyroid tumors as well as to identify miRNAs which could potentially serve as diagnostic and prognostic markers. A total of 14 poorly differentiated, 13 oncocytic poorly differentiated, 72 well differentiated thyroid carcinomas and 8 normal thyroid specimens were studied for expression of 768 miRNAs using PCR-Microarrays. MiRNA expression was different between poorly differentiated and oncocytic poorly differentiated thyroid carcinomas demonstrating individual clusters on the clustering analysis. Both tumor types showed upregulation of miR-125a-5p, -15a-3p, -182, -183-3p, -222, -222-5p and downregulation of miR-130b, -139-5p, -150, -193a-5p, -219-5p, -23b, -451, -455-3p and of miR-886-3p as compared to normal thyroid tissue. In addition, the oncocytic poorly differentiated thyroid carcinomas demonstrated upregulation of miR-221 and miR-885-5p. The difference in expression was also observed between miRNA expression in poorly differentiated and well differentiated tumors. The CHAID algorithm allowed to separate poorly differentiated from well differentiated thyroid carcinomas with a 73–79% accuracy using miR-23b and miR-150 as a separator. Kaplan-Meier and multivariate analysis showed a significant association with tumor relapses (for miR-23b) and with tumor specific death (for miR-150) in poorly differentiated and oncocytic poorly differentiated thyroid carcinomas. MiRNA expression is different in conventional and oncocytic poorly differentiated thyroid carcinomas in comparison to well differentiated thyroid cancers and can be used for discrimination between these tumor types. The newly identified deregulated miRNAs (miR-150, miR-23b) bear the potential to be used in a clinical setting delivering prognostic and diagnostic information.

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Section: Introductionmentioning

confidence: 99%

MicroRNA profile of poorly differentiated thyroid carcinomas: new diagnostic and prognostic insights

Dettmer¹,

Perren²,

Moch³

et al. 2014

Journal of Molecular Endocrinology

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“…Although these tumors were not considered at the Turin Consensus Meeting, they are now recognized as the oncocytic variant of PDTC. The hallmark of OV‐PDTC is the presence of large, polygonal oncocytic cells with granular, eosinophilic cytoplasm, and a large hyperchromatic nucleus, often with prominent macronucleoli . According to some authors, OV‐PDTCs are associated with worse overall and tumor‐specific survival, compared with conventional PDTCs .…”

Section: Discussionmentioning

confidence: 99%

Oncocytic poorly differentiated (insular) thyroid carcinoma mimicking metastatic adenocarcinoma. A case report and review of the literature

Laforga

Cortés

2019

Diagnostic Cytopathology

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We report the cytohistologic and immunohistochemical findings of an oncocytic variant of poorly differentiated thyroid carcinoma in a 76‐year old man with a prior history of prostatic adenocarcinoma. The man complained of a palpable nodule in the right thyroid lobe and cervical lymph node. Fine‐needle aspiration (FNA) in both cases yielded solid clusters of cells/insulae, microfollicles, and isolated atypical cells. Considering the patient's past history, an initial diagnosis of metastasis from prostate adenocarcinoma was considered. However, immunohistochemical staining of liquid‐based cytology specimens (Thin‐Prep) showed diffuse positive results for TTF‐1 and thyroglobulin. The patient underwent total thyroidectomy with bilateral neck dissection. Histologic and immunohistochemical evaluation showed a poorly differentiated oncocytic thyroid carcinoma with lymphovascular invasion and lymph node metastases. To our knowledge, this is the first description of the immunocytochemical evaluation of this rare variant of poorly differentiated thyroid carcinoma using FNA and liquid based cytology.

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“…who were blinded to the clinical data and outcome. The tumours were classified according to the 4th edition of the WHO classification and the Turin criteria for poorly differentiated carcinomas . After review, the study cohort comprised 126 PTCs, 59 FTCs, 34 poorly differentiated thyroid carcinomas (PDs), five FTAs, and two follicular tumours of unknown malignant potential (FTUMPs).…”

Section: Methodsmentioning

confidence: 99%

Diagnostic and prognostic implications of the PAX8–PPARγ translocation in thyroid carcinomas—a TMA‐based study of 226 cases

et al. 2013

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Poorly differentiated oncocytic thyroid carcinoma – diagnostic implications and outcome

Abstract: The Turin criteria can be applied to oncocytic PDTC and patients with this variant have a decreased survival using conventional radioiodine treatment compared to conventional PDTC and might therefore be candidates for novel treatment modalities.

Cited by 53 publications

References 33 publications

MicroRNA profile of poorly differentiated thyroid carcinomas: new diagnostic and prognostic insights

MicroRNA profile of poorly differentiated thyroid carcinomas: new diagnostic and prognostic insights

Oncocytic poorly differentiated (insular) thyroid carcinoma mimicking metastatic adenocarcinoma. A case report and review of the literature

Diagnostic and prognostic implications of the PAX8–PPARγ translocation in thyroid carcinomas—a TMA‐based study of 226 cases

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