Poor utility of serum interleukin-6 levels to predict indolent periprosthetic shoulder infections

Grosso, Matthew J.; Frangiamore, Salvatore J.; Saleh, Anas; Kovac, Mario Farias; Hayashi, Riku; Ricchetti, Eric T.; Bauer, Thomas W.; Iannotti, Joseph P.

doi:10.1016/j.jse.2013.12.023

Cited by 74 publications

(61 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies were published since then on the utility of IL-6 markers for diagnosing PJI [1,9,13,17,19,20,22,45]. Most of them found serum IL-6 to have a very high sensitivity reaching up to 1.00 [1,8,9] and high specificity reaching up to 0.90 Fig.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of diagnostic tests for prosthetic joint infection: a systematic review

Ahmad

Shaker

Saffarini³

et al. 2016

Knee Surg Sports Traumatol Arthrosc

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Accuracy of diagnostic tests for prosthetic joint infection: a systematic review

Ahmad

Shaker

Saffarini³

et al. 2016

Knee Surg Sports Traumatol Arthrosc

View full text Add to dashboard Cite

show abstract

“…Intraoperative antibiotics were given after the synovial fluid and tissue samples were obtained. Fluid and tissue specimens were processed per standard laboratory protocol with cultures held for an average of 11.8 days (range, [6][7][8][9][10][11][12][13][14][15][16][17]. 3,21,29 Fluid specimens were placed into anaerobic fluid vials (BBL Port-A-Cul; Becton, Dickinson and Company, Franklin Lakes, NJ, USA); tissue specimens were transported in sterile containers and processed within 3 hours of collection.…”

Section: Methodsmentioning

confidence: 99%

“…Plates were examined every 2 days. A small 1-mL aliquot was added to thioglycollate enrichment broth, which was incubated for an average of 11.8 days (range, [6][7][8][9][10][11][12][13][14][15][16][17]. Turbid broth was subcultured on any day until the final day of incubation.…”

Section: Methodsmentioning

confidence: 99%

“…These criteria were consistent with current literature 10,26,32,35 and have been used by our group in the evaluation of other diagnostic tests for PJI of the shoulder. 13,16,17 To facilitate the analysis of the diagnostic utility of synovial fluid a-defensin results, the patients were condensed into 2 groups: (1) a noinfection group and (2) an infection group. The no-infection group included revision patients who met criteria for the categories of probable contaminant and no evidence for infection ( Table I).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

α-Defensin as a predictor of periprosthetic shoulder infection

Frangiamore

Saleh

Grosso

et al. 2015

Journal of Shoulder and Elbow Surgery

Self Cite

130

View full text Add to dashboard Cite

“…Synovial CRP and a variety of inflammatory cytokines have been lauded as being superior to serum testing, 33,34 but these tests are not widely available, they are expensive, and they are not consistently reproduced. 35,36 For our study series, the use of preoperative arthrocentesis with both culture and leukocyte cell count was the only diagnostic tool significantly associated with a positive PJI treatment outcome. Although it is unclear if the treating surgeons used similar leukocyte count thresholds to diagnose PJI, it is logical to assume that arthrocentesisbased bacterial culture permits proper identification of the offending organism and permits expedient perioperative use of appropriate antibiotics, which can eradicate infection.…”

mentioning

confidence: 87%

Tertiary care centre adherence to unified guidelines for management of periprosthetic joint infections: a gap analysis

Armstrong

Carli

Abdelbary

et al. 2018

cjs

View full text Add to dashboard Cite

Background:The success rate of surgical treatment for periprosthetic joint infection (PJI) remains inconsistent in the literature. Variability in PJI clinical guidelines and surgeon adherence to guidelines could affect treatment success. The objectives of this study were to appraise current recommendations for PJI management and develop a unified clinical standard of care, to perform a gap analysis of PJI cases in a tertiary institution to determine the rate of guideline adherence, and to determine if adherence to unified PJI guidelines affected 2-year treatment outcomes. Methods: We appraised the PJI guidelines from 3 academic medical societies, and consistent statements were aggregated. We retrospectively reviewed all PJI cases in a tertiary care institution. We defined PJI based on Musculoskeletal Infection Society PJI criteria. Surgeon adherence to preoperative, intraoperative, surgical and medical management guidelines was calculated, and we evaluated the association between guideline adherence and 2-year treatment outcomes. Results: The institutional rate of PJI was 1.13% (38 of 3368). Treatment success was 57.8% at 2 years. Unified guideline adherence percentages varied substantially: 92% of patients had preoperative erythrocyte sedimentation rate and C-reactive protein, 97% had intraoperative tissue cultures, 42% had appropriate preoperative arthrocentesis, and 74% underwent guideline-appropriate surgery. Performing appropriate preoperative arthrocentesis significantly correlated with positive treatment outcomes at 2 years (p = 0.028). Conclusion: Adherence to PJI guidelines varies considerably, indicating that clinicians are either unaware of them or do not recognize their value for PJI treatment. This study shows the need for institution-based PJI treatment pathways that are consistent with published guidelines and the need to monitor adherence. Contexte :Les études ne concordent pas quant au taux de réussite du traitement chirurgical des infections de prothèses articulaires (IPA). Une certaine variabilité dans les lignes directrices sur ces infections et dans l'adhésion des chirurgiens à celles-ci pourrait nuire à la réussite du traitement. La présente étude visait à évaluer les recommandations actuelles sur la prise en charge des IPA afin d'élaborer une norme de soins uniforme, à effectuer une analyse des lacunes entourant les cas d'IPA dans un établissement de soins tertiaires pour déterminer le taux d'adhésion aux lignes directrices, et à déterminer si l'adhésion à des lignes directrices uniformes influençait les issues de traitement après 2 ans. Méthodes : Nous avons évalué les lignes directrices sur les IPA de 3 sociétés médi-cales universitaires, et agrégé des énoncés cohérents. Nous avons également examiné de façon rétrospective tous les cas d'IPA dans un établissement de soins tertiaires. Aux fins de notre étude, l'IPA était définie selon les critères de la Musculoskeletal Infection Society. Nous avons calculé l'adhésion des chirurgiens aux lignes directrices de prise en charge préopératoire, ...

show abstract

Poor utility of serum interleukin-6 levels to predict indolent periprosthetic shoulder infections

Cited by 74 publications

References 17 publications

Accuracy of diagnostic tests for prosthetic joint infection: a systematic review

Accuracy of diagnostic tests for prosthetic joint infection: a systematic review

α-Defensin as a predictor of periprosthetic shoulder infection

Tertiary care centre adherence to unified guidelines for management of periprosthetic joint infections: a gap analysis

Contact Info

Product

Resources

About