Poor Sleep Quality and Changes in Objectively Recorded Sleep After Traumatic Brain Injury: A Preliminary Study

Parcell, Diane L.; Ponsford, Jennie Louise; Redman, Jennifer R.; Rajaratnam, Shanthakumar M W

doi:10.1016/j.apmr.2007.09.057

Cited by 126 publications

(96 citation statements)

References 48 publications

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“…In light of the regenerative effects of SWS (e.g., axonal sprouting and synaptic remodeling), these findings appear to suggest a potential role for SWS in recovery from TBI. Further supporting this hypothesis, Sommerauer et al [81] found that patients with TBI slept 2.5 h longer per 24-h period-and also underestimated their sleep need-relative to matched healthy controls. Alterations in REM sleep have also been detected, including decrease in total REM sleep and reduced REM latency [77,84,85].…”

Section: What Sleep Disorders Occur Following Mtbi?mentioning

confidence: 87%

“…More specifically, patients with mTBI demonstrate increased sleep fragmentation, delayed sleep onset, increased awakenings and time awake during the night, and reduced sleep efficiency (e.g., [81]). Further, at least 3 studies have found that relative to matched healthy controls, patients with mixed-severity TBI demonstrate increased slow-wave sleep (SWS) [22,82], although another study found reduced SWS and lower NREM delta power [83].…”

Section: What Sleep Disorders Occur Following Mtbi?mentioning

confidence: 99%

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Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group

et al. 2016

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Disturbed sleep is one of the most common complaints following traumatic brain injury (TBI) and worsens morbidity and long-term sequelae. Further, sleep and TBI share neurophysiologic underpinnings with direct relevance to recovery from TBI. As such, disturbed sleep and clinical sleep disorders represent modifiable treatment targets to improve outcomes in TBI. This paper presents key findings from a national working group on sleep and TBI, with a specific focus on the testing and development of sleep-related therapeutic interventions for mild TBI (mTBI). First, mTBI and sleep physiology are briefly reviewed. Next, essential empirical and clinical questions and knowledge gaps are addressed. Finally, actionable recommendations are offered to guide active and efficient collaboration between academic, industry, and governmental stakeholders.

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Section: What Sleep Disorders Occur Following Mtbi?mentioning

confidence: 87%

Section: What Sleep Disorders Occur Following Mtbi?mentioning

confidence: 99%

Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group

et al. 2016

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“…Primary outcomes were decided a priori. Based on our previous work 8,11,18 and that of others, 9,19-21 we hypothesized that patients with TBI would show increased wake after sleep onset and longer sleep onset latency, relative to controls.…”

Section: Primary Outcomesmentioning

confidence: 99%

“…7 Studies have been limited by small sample sizes, with variable and inconsistent findings. [8][9][10][11][12] This makes for a difficult characterization of sleep post TBI. Thus, there is a need to establish the specific aspects of sleep that are most affected post TBI as these have important implications for treatment and rehabilitation.…”

Section: Introductionmentioning

confidence: 99%

Sleep Disturbances in Traumatic Brain Injury: A Meta-Analysis

Grima

Ponsford

Rajaratnam

et al. 2016

Journal of Clinical Sleep Medicine

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Study Objectives: Sleep disturbances are frequently reported following traumatic brain injury (TBI); however, the exact disturbances remain unclear. This meta-analysis aimed to characterize sleep disturbance in community dwelling patients with TBI as compared to controls. Methods: Two investigators independently conducted a systematic search of multiple electronic databases from inception to May 27, 2015. Studies were selected if they compared sleep in community dwelling individuals with TBI relative to a control population without head injury. Data were pooled in metaanalysis with outcomes expressed as the standard mean difference (SMD) and 95% confidence interval (CI). The primary outcomes were derived from polysomnography and secondary outcomes were derived from subjective sleep measures. Results: Sixteen studies were included, combining 637 TBI patients and 567 controls, all of whom were community dwelling. Pooled polysomnography data revealed that TBI patients had poorer sleep efficiency (SMD = −0. I NTRO DUCTI O NSleep disturbances are frequently reported following traumatic brain injury (TBI), with over 50% of people experiencing some form of sleep disturbance post TBI.1 Although a large majority of people with TBI generally make a good physical recovery, disrupted sleep can often go untreated, impacting quality of life, impeding rehabilitation and return to pre-injury activities.2-5 Our recent work showed significant interrelationships between daytime sleepiness, daytime fatigue, cognitive impairment, and mood disturbances in TBI. 6 While individuals with TBI are known to report sleep problems, 1 the specific changes to sleep remain poorly characterized.7 Studies have been limited by small sample sizes, with variable and inconsistent findings. [8][9][10][11][12] This makes for a difficult characterization of sleep post TBI. Thus, there is a need to establish the specific aspects of sleep that are most affected post TBI as these have important implications for treatment and rehabilitation. The aim of the current meta-analysis was to characterize both objective sleep disturbances and subjective sleep complaints in individuals with TBI relative to healthy controls. Study outcomes included the comparison of TBI patients to controls across both polysomnography and subjective measures of sleep. It ; Matthew P. Pase, PhD was hypothesized that those with TBI would display widespread objective and subjective sleep deficits as compared to controls without head injury. The present study aimed to summarize current literature, which would identify important avenues for future research. M ETHO DS Study DesignThe search strategy was conducted in accordance with the meta-analysis of observational studies in epidemiology guidelines. 13 Article SearchingOvid Medline, Embase, PsychInfo, Scopus, and the Cochrane Library were systematically searched until May, 27 2015. The search was initially developed by all authors and refined by a librarian at Monash University. The references of recent publications were also hand searc...

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“…Changes in sleep architecture after TBI are inconsistent, because the neural mechanisms contributing to sleep disturbances are multifaceted. The degree of damage to sleep-wake regulating centers such as the ascending reticular formation and associated pathways or neurotransmitter systems affect sleep disturbances [10,11]. Anxiety and depression frequently occur after TBI, and increased depression is associated with decreased sleep quality [12,13].…”

Section: Introductionmentioning

confidence: 99%

Electrophysiologic Evaluation of Diffuse Axonal Injury after Traumatic Brain Injury

Urakami¹

2013

J Neurol Neurophysiol

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Poor Sleep Quality and Changes in Objectively Recorded Sleep After Traumatic Brain Injury: A Preliminary Study

Cited by 126 publications

References 48 publications

Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group

Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group

Sleep Disturbances in Traumatic Brain Injury: A Meta-Analysis

Electrophysiologic Evaluation of Diffuse Axonal Injury after Traumatic Brain Injury

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