Poor Sleep Is Associated With Impaired Cognitive Function in Older Women: The Study of Osteoporotic Fractures

Blackwell, Terri; Yaffe, Kristine; Ancoli‐Israel, Sonia; Schneider, Jennifer L.; Cauley, Jane A.; Hillier, Teresa A.; Fink, Howard A; Stone, Katie L.

doi:10.1093/gerona/61.4.405

Cited by 382 publications

(346 citation statements)

References 42 publications

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“…Increasing age is associated with a decrease in sleep efficiency [4], early morning awakening [5; 6], nocturnal awakenings [1 ] and increased sleep latency [7]. Poor sleep in older people has been linked to cognitive decline [8], an increase in falls [9] and poorer physical and mental health [10] with a significant correlation between cognitive ratings and sleep fragmentation [11]. Sleep changes may be due to any number of factors including age-related effects on the homeostatic and/or circadian regulation of sleep [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Blue-Enriched Lighting for Older People Living in Care Homes: Effect on Activity, Actigraphic Sleep, Mood and Alertness

Hopkins

Morgan

Schlangen

et al. 2017

CAR

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Environmental (little outdoor light; low indoor lighting) and age-related physiological factors (reduced light transmission through the ocular lens, reduced mobility) contribute to a light-deprived environment for older people living in care homes. This study investigates the effect of increasing indoor light levels with blueenriched white lighting on objective (rest-activity rhythms, performance) and self-reported (mood, sleep, alertness) measures in older people. Eighty residents (69 female), aged 86 ± 8 yrs (mean ± SD), participated (MMSE 19 ± 6). Overhead fluorescent lighting was installed in communal rooms (n=20) of seven care homes.Four weeks of blue-enriched white lighting (17000 K  900 lux) were compared with four weeks of control white lighting (4000 K  200 lux), separated by three weeks wash-out. Participants completed validated mood and sleep questionnaires, psychomotor vigilance task (PVT) and wore activity and light monitors (AWL). Restactivity rhythms were assessed by cosinor, non-parametric circadian rhythm (NPCRA) and actigraphic sleep analysis. Blue-enriched (17000 K) light increased wake time and activity during sleep decreasing actual sleep time, sleep percentage and sleep efficiency (p < 0.05) (actigraphic sleep). Compared to 4000 K lighting, blueenriched 17000 K lighting significantly (p < 0.05) advanced the timing of participants' rest-activity rhythm (cosinor), increased daytime and night-time activity (NPCRA), reduced subjective anxiety (HADA) and sleep quality (PSQI). There was no difference between the two light conditions in daytime alertness and performance (PVT). Blue-enriched lighting produced some positive (increased daytime activity, reduced anxiety) and negative (increased night-time activity, reduced sleep efficiency and quality) effects in older people.Keywords: care home, light therapy; mood; elderly; rest-activity; sleep. 3 Graphical AbstractThe effect of blue-enriched 17000 K lighting (right) on the rest-activity, sleep and mood of older people living in care homes has been investigated compared to control 4000 K lighting (middle) (left, original lighting) 4

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Section: Introductionmentioning

confidence: 99%

Blue-Enriched Lighting for Older People Living in Care Homes: Effect on Activity, Actigraphic Sleep, Mood and Alertness

Hopkins

Morgan

Schlangen

et al. 2017

CAR

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“…Sleep fragmentation 1 is a common symptom in older adults and is associated with a number of adverse health outcomes including falls, 2 poor quality of life, 3 poorer cognition, [4][5][6] and depression. 7 Sleep disorders such as sleep apnea contribute to sleep fragmentation in some older adults.…”

Section: Introductionmentioning

confidence: 99%

Regional neocortical gray matter structure and sleep fragmentation in older adults

et al. 2015

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“…While the duration or quantity of sleep is significant, the quality of sleep may be related to cognitive decline too. Several studies have reported that it was the self-reported quality but not the quantity of sleep that affected cognition (Blackwell et al 2006;Nebes et al 2009;Cricco et al 2001). Therefore, the relationship between sleep quantity, quality, and cognitive deficit or dementia has remained elusive.…”

Section: Introductionmentioning

confidence: 99%

Cognitive deficit is associated with phase advance of sleep–wake rhythm, daily napping, and prolonged sleep duration—a cross-sectional study in 2,947 community-dwelling older adults

Auyeung

Lee

Leung

et al. 2012

AGE

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This study aims to examine the phase advance of sleep-wake rhythm, napping habit, nocturnal sleep duration, prolonged sleep latency and insomnia and their relationship with cognitive function. This is a crosssectional study. Participants in this study are 2,947 community-dwelling adults older than 65 years old.Measurements of mini-mental examination (MMSE) score, go-to-bed time, wake-up time, nocturnal sleep duration, prolonged sleep latency, napping, and insomnia were done. The mean (standard deviation) nocturnal sleep hours was 7.96 (1.39) h. Twenty-one percent and 16.2% of the participants complained of prolonged sleep latency longer than 1 h and insomnia, respectively. Fiftysix percent of the participants napped once or more than once weekly. With advancing age, the participants reported longer sleep duration (p<0.001), went to bed earlier, and woke up earlier, which were significant both before and after adjustment. The participants who had lower MMSE score went to bed earlier and woke up earlier, which were statistically significant both before and after adjustment. An inverted U-shaped relationship was observed between MMSE score and napping frequency, p for tend 0.026.The MMSE score decreased when the sleep duration prolonged from 7 h to ≧10 h (p for trend 0.006). No trend was observed from the sleep duration <4 up to 7.9 h (p for trend 0.500). Modest ageindependent phase advance of the sleep-wake rhythm is associated with lower cognitive function. Whether this is a manifestation of early pre-clinical dementia and whether its recognition with early stabilization can slow cognitive decline remain elusive.

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Poor Sleep Is Associated With Impaired Cognitive Function in Older Women: The Study of Osteoporotic Fractures

Abstract: Objectively measured disturbed sleep was consistently related to poorer cognition, whereas total sleep time was not. This finding may suggest that it is disturbance of sleep rather than quantity that affects cognition.

Cited by 382 publications

References 42 publications

Blue-Enriched Lighting for Older People Living in Care Homes: Effect on Activity, Actigraphic Sleep, Mood and Alertness

Blue-Enriched Lighting for Older People Living in Care Homes: Effect on Activity, Actigraphic Sleep, Mood and Alertness

Regional neocortical gray matter structure and sleep fragmentation in older adults

Cognitive deficit is associated with phase advance of sleep–wake rhythm, daily napping, and prolonged sleep duration—a cross-sectional study in 2,947 community-dwelling older adults

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