Poor self‐reported sleep quality and health‐related quality of life in patients with chronic fatigue syndrome/myalgic encephalomyelitis

Abstract

Non-restorative sleep is a hallmark symptom of chronic fatigue syndrome/myalgic encephalomyelitis. However, little is known about self-reported sleep disturbances in these subjects. This study aimed to assess the self-reported sleep quality and its impact on quality of life in a Spanish community-based chronic fatigue syndrome/myalgic encephalomyelitis cohort. A prospective cross-sectional cohort study was conducted in 1,455 Spanish chronic fatigue syndrome/myalgic encephalomyelitis patients. Sleep quality, fatigue, pain, functional capacity impairment, psychopathological status, anxiety/depression and health-related quality of life were assessed using validated subjective measures. The frequencies of muscular, cognitive, neurological, autonomic and immunological symptom clusters were above 80%. High scores were recorded for pain, fatigue, psychopathological status, anxiety/depression, and low scores for functional capacity and quality of life, all of which correlated significantly (all p < 0.01) with quality of sleep as measured by the Pittsburgh Sleep Quality Index. Multivariate regression analysis showed that after adjusting for age and gender, the pain intensity (odds ratio, 1.11; p <0.05), psychopathological status (odds ratio, 1.85; p < 0.001), fibromyalgia (odds ratio, 1.39; p < 0.05), severe autonomic dysfunction (odds ratio, 1.72; p < 0.05), poor functional capacity (odds ratio, 0.98; p < 0.05) and quality of life (odds ratio, 0.96; both p < 0.001) were significantly associated with poor sleep quality. These findings suggest that this large chronic fatigue syndrome/myalgic encephalomyelitis sample presents poor sleep quality, as assessed by the Pittsburgh Sleep Quality Index, and that this poor sleep quality is associated with many aspects of quality of life.

Insomnia is Associated with Depression and Anxiety in Patients Undergoing Noncardiac Surgery

“…The ndings in the present study are in broad agreement with previous studies, which have reported that poor sleep quality was associated with poorer health status, disease severity, impaired daily activities, and reduced survival [24,25]. This study acts as a reminder to enquire about sleep quality in patients with the operation and consider investigation and treatment for potentially treatable cause, including measures to improve factors that adversely affect sleep.…”

“…The observed distributions in the insomnia were summarized in de ned groups based on the scores from ISI as follows: none (0-7), mild (8)(9)(10)(11)(12)(13)(14), moderate (15)(16)(17)(18)(19)(20)(21), severe (22)(23)(24)(25)(26)(27)(28). Depression was rate on PHQ-9 of ve levels: none (0-4), mild (5-9), moderate (10)(11)(12)(13)(14), moderatesevere (15)(16)(17)(18)(19) severe (20)(21)(22)(23)(24)(25)(26)(27). Anxiety was graded according to the score of the GAD-7: none (0-4), mild (5-9), moderate (10-13), moderate-severe (14-18), severe (19)(20)(21).…”

“…Anxiety was graded according to the score of the GAD-7: none (0-4), mild (5-9), moderate (10-13), moderate-severe (14-18), severe (19)(20)(21). And cognition impairment was scaled by the MoCA: none (26-30); mild (18)(19)(20)(21)(22)(23)(24)(25), moderate (≤17).…”

Reduced heart rate variability predicts fatigue severity in individuals with chronic fatigue syndrome/myalgic encephalomyelitis

“…Previous studies have provided strong evidence for autonomic nervous system (ANS) involvement in individuals with CFS/ME, including perturbations in the structure and function of brain (reflected by fMRI testing) [4][5][6][7][8][9][10][11]. In brief, cerebral blood flow volume changes and reduced HRV may lead to greater exacerbation of ANS symptoms in individuals with CFS/ME.…”

A botanical product containing cistanche and ginkgo extracts improves chronic fatigue syndrome: a randomized, double-blind, placebo-controlled study

“…These data were consistent with those from the CFS assessment. Poor sleep quality was widely reported in patients with CFS [16], and nocturia was associated with poor sleep quality [17,18]. In our study, we observed a signi cantly (P < 0.01) improved frequency of nocturia in the subjects of the product group (data not shown).…”