Poor Response Inhibition as a Predictor of Problem Drinking and Illicit Drug Use in Adolescents at Risk for Alcoholism and Other Substance Use Disorders

Nigg, Joel T.; Wong, Maria M.; Martel, Michelle M.; Jester, Jennifer M.; Puttler, Leon I.; Glass, Jennifer M.; Adams, Kenneth M.; Fitzgerald, Hiram E.; Zucker, Robert A.

doi:10.1097/01.chi.0000199028.76452.a9

Cited by 496 publications

(411 citation statements)

References 16 publications

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“…Longitudinal studies further support the role of disinhibition on alcoholrelated problems in late adolescence (Nigg et al, 2006;Tarter, Kirisci, Habeych, Reynolds, & Vanyukov, 2004). To this end, behavioural disinhibition (as a personality trait associated with increased risk-taking) appears to be associated with alcohol consumption, and in some cases, is suggested to predict alcohol use (Courtney et al, 2012;Fernie et al, 2013;Fernie, Cole, Goudie, & Field, 2010).…”

Section: Risky To Whiskymentioning

confidence: 85%

“…The notion of alcohol consumption being a determinant of disinhibition has been supported by some longitudinal research, suggesting those less able to inhibit behaviour will develop more alcohol use issues in later years (Nigg et al, 2006;Tarter et al, 2004). Often viewed as a trait ability that is independent of contextual influences (Gladstone & Parker, 2005), it could be assumed that inhibitory control cannot be affected by situational or external cues (such as intoxication or peers).…”

Section: Disinhibitionmentioning

confidence: 99%

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The influence of groups and alcohol consumption on individual risk-taking

Erskine-Shaw

Monk

Qureshi

et al. 2017

Drug and Alcohol Dependence

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Section: Risky To Whiskymentioning

confidence: 85%

Section: Disinhibitionmentioning

confidence: 99%

The influence of groups and alcohol consumption on individual risk-taking

Erskine-Shaw

Monk

Qureshi

et al. 2017

Drug and Alcohol Dependence

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“…In addition, poor response inhibition has been demonstrated to be a predictor of problem drinking in adolescents at risk for alcoholism (e.g. Nigg et al 2006).…”

Section: Discussionmentioning

confidence: 99%

Alcohol cues increase cognitive impulsivity in individuals with alcoholism

et al. 2007

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Background Individuals with alcoholism are characterized by both attentional bias for alcohol cues and prepotent response inhibition deficit. We tested the hypothesis that alcoholics exhibit greater cognitive disinhibition when the response to be suppressed is associated with alcohol-related information. Methods Forty recently detoxified individuals with alcoholism were compared with 40 healthy non-substance abusers on the "Alcohol-Shifting Task", a variant of the go/no-go paradigm requiring a motor response to targets and no response to distracters. The aim was to test the ability of alcoholics to discriminate between alcohol-related and neutral words. Sometimes, the alcohol-related words were the targets for the "go" response, with neutral words as distracters, sometimes the reverse. Several shifts in target type occurred during the task. Results Alcoholics made significantly more commission errors (i.e., press a key when a distracter displayed) and more omission errors (i.e., not press a key when a target displayed) than controls. Moreover, the number of commission errors was greater in alcoholics when alcoholrelated stimuli had to be detected. Conclusions These results demonstrate that alcoholics exhibit a basic prepotent response inhibition deficit, which is enhanced when the response to be suppressed is related to alcohol. We discuss clinical and theoretical implications of these findings.

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“…Self-control is important because the level of childhood self-control predicts long-term outcomes, including mental health, substance abuse, financial independence, and criminal behavior (11). Individuals at risk for substance abuse typically have deficits in self-control (12)(13)(14)(15)(16). Dysfunction of the prefrontal cortex (PFC), including dorsolateral PFC, anterior cingulate cortex (ACC), and medial orbitofrontal cortex, play a key role in addiction (12,17,18).…”

mentioning

confidence: 99%

Brief meditation training induces smoking reduction

Tang

Posner

2013

Proc. Natl. Acad. Sci. U.S.A.

171

119

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More than 5 million deaths a year are attributable to tobacco smoking, but attempts to help people either quit or reduce their smoking often fail, perhaps in part because the intention to quit activates brain networks related to craving. We recruited participants interested in general stress reduction and randomly assigned them to meditation training or a relaxation training control. Among smokers, 2 wk of meditation training (5 h in total) produced a significant reduction in smoking of 60%; no reduction was found in the relaxation control. Resting-state brain scans showed increased activity for the meditation group in the anterior cingulate and prefrontal cortex, brain areas related to self-control. These results suggest that brief meditation training improves self-control capacity and reduces smoking.addiction | anterior cingulate cortex | brain state | integrative body-mind training | mindfulness S moking harms nearly every organ of the body, causing many diseases and compromising smokers' health (1). Despite the negative consequences, many smokers have difficulty quitting or even reducing tobacco use (2). In addition, many teenagers are added to the smoking roll each year and may be at risk for abuse of other substances (2). Because tobacco use is often thought of as a gateway to other drug use, reducing smoking might reduce the vulnerability of youths to cocaine and other drugs (3). Although public health campaigns may have decreased the number of smokers, current methods for aiding those who persist in smoking have had limited success (4, 5). These failures may be a result of the inability to relieve withdrawal symptoms, stress, and cue-induced cravings, which often leads to drug seeking and taking (6-10). This urgent need calls for a short-term, effective intervention for reducing smoking behavior and cravings (2).One reason for addiction to tobacco may involve a deficit in selfcontrol. Self-control is important because the level of childhood self-control predicts long-term outcomes, including mental health, substance abuse, financial independence, and criminal behavior (11). Individuals at risk for substance abuse typically have deficits in self-control (12-16). Dysfunction of the prefrontal cortex (PFC), including dorsolateral PFC, anterior cingulate cortex (ACC), and medial orbitofrontal cortex, play a key role in addiction (12,17,18). In cigarette smokers, regional cerebral blood flow was reduced in the left dorsal ACC, and this correlated with a decrease in craving after smoking the first cigarette of the day (19). These reports raise the question of whether impaired self-control could be ameliorated and strengthened with intervention, and thus potentially change smoking behavior.There is emerging evidence that mindfulness meditation has the potential to ameliorate negative outcomes resulting from deficits in self-control (20-25). Although preliminary findings suggest mindfulness training shows some proof of efficacy in substance abuse, these studies are replete with limitations, including a lack of ...

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Poor Response Inhibition as a Predictor of Problem Drinking and Illicit Drug Use in Adolescents at Risk for Alcoholism and Other Substance Use Disorders

Cited by 496 publications

References 16 publications

The influence of groups and alcohol consumption on individual risk-taking

The influence of groups and alcohol consumption on individual risk-taking

Alcohol cues increase cognitive impulsivity in individuals with alcoholism

Brief meditation training induces smoking reduction

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