Poor quality of life and functioning in bipolar disorder

Abstract

BackgroundThis study explores the association of demographic and clinical features with quality of life and functioning in individuals with bipolar disorder.MethodsAdult participants (N = 482) with bipolar I or II disorder were enrolled in a comparative effectiveness study across eleven study sites and completed baseline measures of medical and psychiatric history, current mood, quality of life, and functioning. Participants with at least mildly depressive or manic/hypomanic symptomatic severity were randomized to receive lithium or quetiapine in addition to adjunctive personalized treatment for 6 months.ResultsParticipants with more severe depressive and irritability symptoms had lower quality of life and higher functional impairment. All psychiatric comorbid conditions except substance use disorder were associated with worse quality of life. On average, females had lower quality of life than males. Patients who were married, living as married, divorced, or separated had worse functional impairment compared with patients who were single or never married. A composite score of social disadvantage was associated with worse functioning and marginally associated with worse quality of life. Symptom severity did not moderate the effect of social disadvantage on quality of life or functioning.ConclusionsOur findings highlight that depression, irritability, and psychiatric comorbid conditions negatively impact quality of life and functioning in bipolar disorder. The study suggests that individuals with social disadvantage are at risk for functional impairment. Trial Registration This study is registered with ClinicalTrials.gov. Identification number: NCT01331304

Functioning in euthymic patients with bipolar disorder: A systematic review and meta‐analysis using the Functioning Assessment Short Test

“…Likewise, claims data from the National Health Insurance Research Database used in a cohort of 502 patients detected poorer employments outcomes in patients than in HCs, with a greater risk of occupational deterioration in the years after disease incidence 49 . In addition, studies suggest that the social disadvantages (including education level, employment status, income level, and occupational prestige) frequently seen in this population increase their risk of FI 50 …”

Systemic challenges in bipolar disorder management: A patient‐centered approach

“…Challenges in bipolar disorder (BD) management shared by psychiatrists and patients across the USA include poorly controlled mood episodes, incomplete remission with cognitive decline, social dysfunction, and diminished quality of life . The problems faced by patients are broader than a range of symptoms targeted by available pharmacologic and psychosocial treatments, and, for many, reflect the lived negative experience of low self‐esteem, impaired sense of identity, isolation, and social stigma, all of which can be exacerbated by inadequate mental health care .…”

More than Half of Bipolar Patients attending Emanuel Mental Specialized Hospital has Poor Quality of Life, Emanuel Mental Specialized Hospital, Ethiopia: Facility- Based Cross-Sectional Study Design

“…This study was in line with study done in UK. Participants with higher educational attainment appeared to have good quality of life [22][23][24][25][26][27][28][29][30][31][32]. People with bipolar disorder have poor quality of life than the general population which is in line with study done in pristine, England [33].…”

“…In our study sex of the patient was not significantly associated with quality of life. But study did in USA show females had lower quality of life than males [31].…”