Poor plasma status of carotene and vitamin C is associated with higher mortality from ischemic heart disease and stroke Basel Prospective Study

Gey, K. F.; Stähelin, Hannes; Eichholzer, Monika

doi:10.1007/bf00210955

Cited by 281 publications

(123 citation statements)

References 12 publications

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“…This contrasts with results in healthy middle-aged US smokers [14], and in Swiss with a 42% smoking prevalence [15]. Since smoking was strongly predictive in PRIME and was associated with low carotenoid levels, these results [14,15] may have been due to confounding by lifestyle factors, e.g. fruit/vegetable intake.…”

Section: Carotenoidscontrasting

confidence: 69%

Low plasma retinol predicts coronary events in healthy middle-aged men: The PRIME Study

et al. 2010

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a b s t r a c tThe role of plasma retinol and carotenoids in coronary heart disease (CHD) remains unclear. The PRIME Study prospectively evaluated these in France and Northern Ireland in 9758 men aged 50-59 years who were free of CHD at baseline. After five years' follow-up 150 incident cases of CHD (non-fatal myocardial infarction and fatal CHD) were compared with 285 controls matched for age, date of blood collection and study centre. Geometric means of major carotenoids did not differ significantly between cases and controls (P > 0.05), whereas the absolute and lipid-standardized plasma retinol levels were 9% lower in cases than controls in both countries (P < 0.002), without correlation with carotenoids. After adjusting for risk factors, the relative risks (RRs) of CHD in the first four quintiles of retinol distribution in controls (≤601, −683, −760, and −846 g/l) were 2.65 (P = 0.0009), 1.70, 1.03, and 1.12 (all P > 0.05) respectively, relative to the top quintile (retinol ≥846 g/l; linear trend P = 0.0001). The 10th percentile of lipid-standardized retinol (≤544 g/l) predicted an RR of 4.7 (P < 0.001). The risk associated with low retinol was comparable to strong risk factors (e.g. HDL-cholesterol, Interleukin-6) and behaved additively.In conclusion, plasma retinol levels of <601 g/l in a fifth of middle-aged European men place them at an approximately threefold RR of developing CHD. Thus the intake of vitamin A might be too low in middle-aged men. These findings must be confirmed.

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Section: Carotenoidscontrasting

confidence: 69%

Low plasma retinol predicts coronary events in healthy middle-aged men: The PRIME Study

et al. 2010

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“…There have been three major epidemiological complementary studies of the association between low plasma concentration of diet-derived antioxidants and the risk of IHD and stroke: the WHO MONICA Project (1989); the Edinburgh Angina-Control Study (Riemersma et al 1991); the Basel Prospective Study (Gey et al 1993). These studies consistently revealed an association between increased risk of IHD (and stroke) and low plasma concentrations of antioxidants.…”

Section: Fruit and Vegetables (Antioxidants)mentioning

confidence: 99%

Nutrition, ageing and ill health

1998

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There are physical, mental, social and environmental changes which take place with ageing; for example, decreased physical activity, increase in body fat, decrease in lean body mass and consequently decreased energy intake may be associated with physiological functions that affect metabolism, nutrient intake, physical activity and risk of disease. There are now many studies which have found that undernutrition is prevalent and often unrecognized in patients admitted to hospitals and institutions. There is also evidence which links protein-energy undernutrition or its markers with clinical outcomes in acute and non-acute hospital settings and that nutritional supplements can improve outcomes in some of these settings. However, most clinically-available nutrition screening instruments lack sensitivity and specificity, and abnormal nutritional indicators may simply reflect effects of age, functional disability, or severe underlying disease. Thus, causal relationship cannot be assumed without a sufficiently powerful intervention study which adequately adjusts for the effects of non-nutritional factors, such as the number and severity of co-morbid conditions on clinical outcome.

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“…Antioxidants prevent the oxidation of low-density lipoproteins and may therefore reduce the occurrence of ischaemic heart disease and cerebrovascular disease (CVA) (Steinberg et al, 1989;Gey et al, 1993). Since¯avonoids are effective antioxidants, it is plausible that they provide protection against CVA (Shutenko et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Quercetin intake and the incidence of cerebrovascular disease

et al. 2000

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Objective: To study the relation between intake of the antioxidant¯avonoid quercetin and subsequent incidence of cerebrovascular disease (CVA). Design: A cohort study carried out among 9208 Finnish men and women 15 y or more of age and initially free from cardiovascular disease. During a 28 y follow-up period in 1967 ± 1994, a total of 824 cases with CVA were diagnosed. Methods: Food consumption data were collected using a dietary history interview method covering the total habitual diet during the previous year. Results: Quercetin intake was not associated with CVA incidence. The relative risk of CVA adjusted for age, serum cholesterol, body mass index, smoking, hypertension, diabetes, geographical area, occupation and intake of beta-carotene, vitamin E, vitamin C, ®bre, various fatty acids, and energy between the highest and lowest quartiles of quercetin intake was 0.99 (95% con®dence interval (CI) 0.71 ± 1.38) for men and 0.85 (CI 0.60 ± 1.21) for women. In contrast, apples, the major source of quercetin in the study population, showed a signi®cant inverse association both in men and women, mainly due to an association with thrombotic or embolic stroke. The relative risks of thrombotic stroke after further adjustment for quercetin intake were 0.59 (CI 0.35 ± 0.99; P 0.45) and 0.61 (CI 0.33 ± 1.12: P for trend 0.02) for men and women, respectively. Conclusions: The results suggest that the intake of apples is related to a decreased risk of thrombotic stroke. This association apparently is not due to the presence of the antioxidant¯avonoid quercetin.

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Poor plasma status of carotene and vitamin C is associated with higher mortality from ischemic heart disease and stroke Basel Prospective Study

Cited by 281 publications

References 12 publications

Low plasma retinol predicts coronary events in healthy middle-aged men: The PRIME Study

Low plasma retinol predicts coronary events in healthy middle-aged men: The PRIME Study

Nutrition, ageing and ill health

Quercetin intake and the incidence of cerebrovascular disease

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