Poor pharmacological adherence to inhaled medicines compared with oral medicines in Japanese patients with asthma and chronic obstructive pulmonary disease

Imamura, Yohei; Kawayama, Tomotaka; Kinoshita, Takashi; Sakazaki, Yuki; Yoshida, Makoto; Takahashi, Koichiro; Fujii, Kenichi; Ando, Masayuki; Hoshino, Tomoaki; Iwanaga, Tomoaki; Kohrogi, Hirotsugu; Nakanishi, Yoichi; Mukae, Hiroshi; Watanabe, Kentaro; Hayashi, Shinichiro; Kadota, Jun‐ichi; Toshihiko,; Inoue, Hiromasa; T, Tochigi; Fujita, Jiro; Nakamura, Hiroshi

doi:10.1016/j.alit.2016.10.008

Cited by 12 publications

(14 citation statements)

References 9 publications

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“…The ASK-20 questionnaire is useful for identifying the patient-specific adherence barriers using the total ASK-20 scores and TBCs (14-16). We demonstrated that the adherence to inhaled medicines was poorer than to oral medicines in patients with COPD and asthma (13). However, we were unable to identify the differences in the barriers between the different drug formulations based on the total ASK-20 scores and TBCs in patients with COPD and asthma.…”

Section: Discussionmentioning

confidence: 99%

“…Patient characteristics-including the age, sex, body mass index (BMI), smoking habits, presence of comorbid diseases, disease control levels, adherence levels to the selected inhaled and oral medicines, and information on all regular inhaled and oral medications-were recorded (13, 17). The presence of COPD was defined based on the following criteria: 1) age >40 years; 2) smoking history >0 pack-years; 3) fixed airflow obstruction with a forced expiratory volume in 1 second (FEV 1 )/forced vital capacity (FVC) ratio <70%; and 4) reversibility of FEV 1 <12% and <200 mL after administration of bronchodilators in accordance with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guideline (1).…”

Section: Methodsmentioning

confidence: 99%

“…From medical records, physicians selected the best pre-bronchodilation values of FVC and FEV 1 during stable disease status. Adherence to the selected inhaled and oral medicines within 6 months before enrolment was assessed based on the questionnaire findings and prescription refill methods, and poor adherence to medicines was defined as <80% of adherence to inhaled or oral medicine, as determined by either method (13, 21-24). All data were those values from within six months before enrolment.…”

Section: Methodsmentioning

confidence: 99%

“…Previous reports have demonstrated that adherence to inhaled medicines is worse than that to oral, injected, and transdermal medicines (9-12). In Japan, adherence to inhaled medicines has been reported to be significantly poorer than that to oral medicines in patients with COPD and asthma (13).…”

Section: Introductionmentioning

confidence: 99%

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Differences in Adherence Barriers to Inhaled Medicines between Japanese Patients with Chronic Obstructive Pulmonary Disease and Asthma Evaluated using the "Adherence Starts with Knowledge 20" (ASK-20) Questionnaire

et al. 2019

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Objective This multicenter, cross-sectional, non-interventional trial aimed to investigate adherence barriers to inhaled medicines when compared with oral medicines in Japanese patients with chronic obstructive pulmonary disease (COPD) and asthma. Methods The self-reporting "Adherence Starts with Knowledge 20" (ASK-20) questionnaire was administered for adherence barriers of inhaled and oral medicines to outpatients with regular clinic attendance. Results Patients with COPD and asthma reported different adherence barriers to inhaled medicines. Independent adherence barriers (odds ratio [95% confidence interval]) to inhaled medicines relative to those for oral medicines among patients with COPD and asthma were those related to item Q8 ( "I know if I am reaching my health goals"; 2.49 [1.39-4.47]; p=0.0022) and item Q2 ( "I run out of my medicine because I do not get refills on time"; 2.69 [1.26-5.75]; p=0.0127), respectively. Among patients with poor adherence to only inhaled medicines, those with COPD and asthma recognized item Q3 ( "consuming alcohol and taking medicines"; 6.63 [1.27-34.7]; p<0.05) and item Q1 ( "forget to take medicines only sometimes"; 4.29 [1.83-10.0]; p<0.05), respectively, were recognized as independent adherence barriers to inhaled medicines. The total ASK-20 scores and total barrier counts in patients with poor adherence to inhaled medicines were significantly higher than in those without poor adherence among patients with asthma (p=0.0057) but not those with COPD (p>0.05). Conclusion These results will aid in personalizing education on adherence to inhaled medicines among patients with COPD and asthma.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Differences in Adherence Barriers to Inhaled Medicines between Japanese Patients with Chronic Obstructive Pulmonary Disease and Asthma Evaluated using the "Adherence Starts with Knowledge 20" (ASK-20) Questionnaire

et al. 2019

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“…The use of different methods of assessing adherence would provide different results. Second, the majority of drugs used for COPD are inhaled, and inhaled drugs carry different implications for the evaluation of adherence than do oral medications 12. During the study of medication adherence, each case has to be qualitatively defined as being adherent or non-adherent, which depends substantially on the method of measurement used and the period during which adherence is assessed (Figure 1).…”

Section: Assessing Treatment Adherence In Patients With Copdmentioning

confidence: 99%

<p>Status of and strategies for improving adherence to COPD treatment</p>

Lόpez-Campos¹,

Gallego²,

Hernández³

2019

COPD

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Despite the wide application of adherence as a concept, the definition, evaluation and improvement of the adherence to treatment by patients with chronic obstructive pulmonary disease (COPD) still present some challenges. First, it is necessary to clearly define the concepts of treatment adherence, compliance and persistence. Second, it is critical to consider the various methods of evaluating and quantifying adherence when interpreting adherence studies. In addition, the advantages and disadvantages of the different ways of measuring treatment adherence should be taken into account. Another subject of some debate is the number of variables associated with COPD treatment adherence. Adherence is a complex concept that goes beyond the dosage or the use of inhalation devices, and a number of variables are involved in determining adherence, from the clinical aspects of the disease to the patient's confidence in the doctor's expertise and the level of social support experienced by the patient. Notably, despite these challenges, the importance of adherence has been well established by clinical trials and routine clinical practice. The available evidence consistently shows the substantial impact that a lack of adherence has on the control of the disease and its longterm prognosis. For these reasons, the correct evaluation of therapeutic adherence should be a key objective in clinical interviews of patients. In recent years, various initiatives for improving adherence have been explored. All these initiatives have been based on patient education. Therefore, health care professionals should be aware of the issues pertaining to adherence and take the opportunity to educate patients each time they contact the health care system.

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Clinical outcomes of children using a metered dose inhaler with a sleeve attachment device to improve ease of use

Mapondela¹,

Dey²,

Levin³

2023

Journal of Allergy and Clinical Immunology: Global

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Poor pharmacological adherence to inhaled medicines compared with oral medicines in Japanese patients with asthma and chronic obstructive pulmonary disease

Cited by 12 publications

References 9 publications

Differences in Adherence Barriers to Inhaled Medicines between Japanese Patients with Chronic Obstructive Pulmonary Disease and Asthma Evaluated using the "Adherence Starts with Knowledge 20" (ASK-20) Questionnaire

Differences in Adherence Barriers to Inhaled Medicines between Japanese Patients with Chronic Obstructive Pulmonary Disease and Asthma Evaluated using the "Adherence Starts with Knowledge 20" (ASK-20) Questionnaire

<p>Status of and strategies for improving adherence to COPD treatment</p>

Clinical outcomes of children using a metered dose inhaler with a sleeve attachment device to improve ease of use

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