Poor performance of monocyte-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, and fibrinogen when screening for occult infection among patients with sequelae of suppurative hip arthritis before total hip arthroplasty

Jiang, Wenyu; Xu, Hong; Wang, Xing; Xie, Jinwei; Huang, Qiang; Zhou, Zongke; Pei, Fuxing

doi:10.1007/s00264-022-05474-2

Cited by 1 publication

(1 citation statement)

References 32 publications

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“…There were limited studies relating NLR and MLR to PJI. Jiang et al looked at the association between NLR or MLR and PJI in septic arthritis patients undergoing THA to detect any occult infections and suggested that NLR and MLR are unreliable biomarkers [ 79 ]. In a preliminary study, Zhao et al observed higher values of NLR and MLR during the incubation period in the cases of PJI, and suggested that it is potentially useful in early postoperative infection [ 80 ].…”

Section: Methodsmentioning

confidence: 99%

Current relevance of biomarkers in diagnosis of periprosthetic joint infection: an update

Tripathi,

Tarabichi,

Parvizi

et al. 2023

Arthroplasty

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With a significant rise in the number of arthroplasty procedures performed worldwide, the increasing revision burden posed by periprosthetic joint infection (PJI) is a matter of growing concern. In spite of various attempts to diagnose PJI, there are no defined tests that can be called a gold standard. Given the importance of early diagnosis in PJI, newer tests and biomarkers have been introduced to improve cumulative diagnostic accuracy. Novel biomarkers like calprotectin, lipocalcin, monocyte-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and platelet-to-mean platelet volume ratio have demonstrated a potential as diagnostic biomarkers for PJI. This article discusses the relevance of available and newly described diagnostic biomarkers to provide a perspective on the practical applicability in current medical practice, as well as highlights some recent advances in biomarkers for the diagnosis of PJI.

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Section: Methodsmentioning

confidence: 99%