Poor Outcome of Intestinal Ischemic Manifestations of COVID-19

Norsa, Lorenzo; Bonaffini, Pietro Andrea; Indriolo, A.; Valle, Clarissa; Sonzogni, Aurelio; Sironi, Sandro

doi:10.1053/j.gastro.2020.06.041

Cited by 38 publications

(40 citation statements)

References 8 publications

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“…Gastrointestinal [GI] symptoms have been described in 10% of patients with COVID-19 infection . [7] In a recent meta-analysis of 29 studies the COVID-10 induced GI symptoms symptoms were anorexia (21%), nausea / vomiting (7%), diarrhea (9%), and abdominal pain (3%). [8] …”

Section: Discussionmentioning

confidence: 99%

Our early experience with mesenteric ischemia in COVID-19 positive patients

Mahruqi

Stephen

Abdelhedy

et al. 2021

Annals of Vascular Surgery

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Section: Discussionmentioning

confidence: 99%

Our early experience with mesenteric ischemia in COVID-19 positive patients

Mahruqi

Stephen

Abdelhedy

et al. 2021

Annals of Vascular Surgery

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“…Moreover, cases of mesenteric ischemia were reported in the conservative oxygen therapy group. We therefore posit that comparable lower levels of

could also be deleterious in critically ill patients with COVID-19, given that intestinal ischemia is a commonly reported complication ( 36 ). On the other hand, liberal use of oxygen resulting in hyperoxemia (

of >100 mmHg) should also be avoided.…”

Section: Hyperoxia and Clinical Outcomes In Ardsmentioning

confidence: 99%

Hyperoxia and modulation of pulmonary vascular and immune responses in COVID-19

Hanidziar

Robson

2021

American Journal of Physiology-Lung Cellular and Molecular Phys

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Oxygen is the most commonly used therapy in hospitalized patients with COVID-19. In those patients who develop worsening pneumonia and acute respiratory distress syndrome (ARDS), high concentrations of oxygen may need to be administered for prolonged time periods, often together with mechanical ventilation. Hyperoxia, although lifesaving and essential for maintaining adequate oxygenation in the short-term, may have adverse long-term consequences upon lung parenchymal structure and function. How hyperoxia per se impacts lung disease in COVID-19 has remained largely unexplored. Numbers of experimental studies have previously established that hyperoxia is associated with deleterious outcomes inclusive of: perturbations in immunologic responses; abnormal metabolic function and alterations in hemodynamics and alveolar barrier function. Such changes may ultimately progress into clinically evident lung injury, adverse remodeling and result in parenchymal fibrosis when exposure is prolonged. Given that significant exposure to hyperoxia in patients with severe COVID-19 may be unavoidable to preserve life, these sequelae of hyperoxia, superimposed on the cytopathic effects of SARS-CoV-2 virus may well impact pathogenesis of COVID-19-induced ARDS.

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“…Some studies used abdominal diagnostic imaging in patients with SARS-CoV-2 infection to assess their intestinal condition and provide evidence for GI involvement. The most frequently reported observations are intestinal ischemia, including vessel thrombosis/embolism in the small bowel and/or colon and ischemic colitis [ 45 , 46 , 47 , 48 , 49 , 50 , 51 ]. Bhayana et al examined 42 abdominal CT scans of 412 hospitalized patients with COVID-19 [ 48 ].…”

Section: Clinical Gi Featuresmentioning

confidence: 99%

Clinical Features and Pathogenic Mechanisms of Gastrointestinal Injury in COVID-19

Mitsuyama

Tsuruta

Takedatsu

et al. 2020

JCM

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the global coronavirus disease 2019 (COVID-19) outbreak. Along with the respiratory tract, the gastrointestinal (GI) tract is one of the main extra-pulmonary targets of SARS-CoV-2 with respect to symptom occurrence and is a potential route for virus transmission, most likely due to the presence of angiotensin-converting enzyme 2. Therefore, understanding the mechanisms of GI injury is crucial for a harmonized therapeutic strategy against COVID-19. This review summarizes the current evidence for the clinical features of and possible pathogenic mechanisms leading to GI injury in COVID-19.

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Poor Outcome of Intestinal Ischemic Manifestations of COVID-19

Cited by 38 publications

References 8 publications

Our early experience with mesenteric ischemia in COVID-19 positive patients

Our early experience with mesenteric ischemia in COVID-19 positive patients

Hyperoxia and modulation of pulmonary vascular and immune responses in COVID-19

Clinical Features and Pathogenic Mechanisms of Gastrointestinal Injury in COVID-19

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