Poor Outcome of Acute Respiratory Infection in Young Children with Underlying Health Condition in Brazil

Durigon, Giuliana Stravinskas; Oliveira, Danielle Bruna Leal; Felício, Maria C.C.; Finelli, Cristiane; Pereira, Maria Fernanda Bádue; Storni, Juliana Gamo; Caldeira, Raquel Negrão; Berezin, Reni Chehter; Durigon, Edison Luiz; Berezin, Eitan Naaman

doi:10.1016/j.ijid.2015.03.003

Cited by 16 publications

(18 citation statements)

References 30 publications

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“…Particularly, hRSVs were more frequently detected during autumn (Fisher's exact, P = .004), a pattern already observed in surveillance studies carried out in two distinct São Paulo city hospitals. 22,23 HCoV were more frequently detected during winter (Fisher's exact, P = .011; Figure 1D), as observed previously in a study conducted during 20 years in the United States. 24 The fifth similarity included statistically significant associations of FLU and hRSV infections with more severe symptoms such as fever (Fisher's exact, P = .007 and P = .02, respectively) and of hRSV infections with dyspnea (Fisher's exact, P = .038) ( Figure 1E) Because of coinfections in several patients, the number of individual virus detections (N = 252), including HCoV (N = 34) and hPiV (N = 28), were higher than the number of infected patients.…”

Section: Resultssupporting

confidence: 85%

Typical epidemiology of respiratory virus infections in a Brazilian slum

Góes

Zerbinati

Tateno

et al. 2019

Journal of Medical Virology

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Host population size, density, immune status, age structure, and contact rates are critical elements of virus epidemiology. Slum populations stand out from other settings and may present differences in the epidemiology of acute viral infections. We collected nasopharyngeal specimens from 282 children aged ≤5 years with acute respiratory tract infection (ARI) during 2005 to 2006 in one of the largest Brazilian slums. We conducted real-time reverse transcription-polymerase chain reaction (RT-PCR) for 16 respiratory viruses, nested RT-PCR-based typing of rhinoviruses (HRVs), and collected clinical symptoms. Viruses were common causes of respiratory disease;with ≥1 virus being detected in 65.2% of patients. We detected 15 different viruses during 1 year with a predominance of HRV (33.0%) and human respiratory syncytial virus (hRSV, 12.1%) infections, and a high rate of viral coinfections (28.3%). We observed seasonality of hRSV, HRV and human coronavirus infections, more severe symptoms in hRSV and influenza virus (FLU) infections and prolonged circulation of seven HRV clusters likely representing distinct serotypes according to genomic sequence distances. Potentially unusual findings included the absence of human metapneumovirus detections and lack of typical FLU seasonal patterns, which may be linked to the population size and density of the slum. Nonetheless, most epidemiological patterns were similar to other studies globally, suggesting surprising similarities of virus-associated ARI across highly diverse settings and a complex impact of population characteristics on respiratory virus epidemiology. K E Y W O R D S acute respiratory infection, Brazil, epidemiology, real-time polymerase chain reaction, respiratory tract infections, slum, viruses ---

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Section: Resultssupporting

confidence: 85%

Typical epidemiology of respiratory virus infections in a Brazilian slum

Góes

Zerbinati

Tateno

et al. 2019

Journal of Medical Virology

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“…Previous studies have reported that RSV was the primary cause of SARI in hospitalized children [28][29][30]. In contrast, PIC (34.0%) was the most common pathogen in our sample, although the findings in Beijing and Shanghai differed.…”

Section: Discussioncontrasting

confidence: 81%

“…Given the high co-infection rate in our study, we did not investigate associations between clinical characteristics and individual viral infections. A previous study found that RSV infections were more strongly associated with comorbidities and bronchiolitis than were non-RSV infections [29]. However, it is not clear whether symptoms can be used to identify specific viral infections, and we concluded that no individual symptoms were specific to any viral infection.…”

Section: Discussionmentioning

confidence: 66%

Comparison of viral and epidemiological profiles of hospitalized children with severe acute respiratory infection in Beijing and Shanghai, China

Zhao

Shen

et al. 2019

BMC Infect Dis

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Background No comparison data have been reported on viral and epidemiological profiles of hospitalized children with severe acute respiratory infection (SARI) in Beijing or Shanghai, China. Methods We collected 700 nasopharyngeal aspirates (NPA) from hospitalized children with SARI in Beijing (northern China) and Shanghai (southern China). Multiple respiratory viruses (including 15 common viruses) were screened by validated polymerase chain reaction (PCR) or real-time reverse transcription-PCR assays and confirmed by sequencing. Demographic data and the distribution of viral infections were also examined. Results Of 700 samples, 547 (78.1%) tested positive for viral infections. The picornaviruses (PIC), which included rhinovirus (RV) and enterovirus (EV), were the most common (34.0%), followed by respiratory syncytial virus (RSV) (28.3%), human bocavirus (HBoV) (19.1%), adenovirus (ADV) (13.7%), human coronaviruses (HCoV) (10.7%), influenza A and B (8.9%), parainfluenza virus (PIV 1–3) (7.9%), and human metapneumovirus (HMPV) (5.0%). PIC (RV/EV) and RSV were the most prevalent etiological agents of SARI in both cities. The total and age-matched prevalence of RSV, HCoV, and hMPV among SARI children under 5 years old were significantly higher in Beijing than in Shanghai. Different age and seasonal distribution patterns of the viral infections were found between Beijing and Shanghai. Conclusions Viral infection was tested and shown to be the most prevalent etiological agent among children with SARI in either the Beijing or the Shanghai area, while showing different patterns of viral and epidemiological profiles. Our findings provide a better understanding of the roles of geographic location and climate in respiratory viral infections in hospitalized children with SARI.

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“…Infants with underlying risk factors, particularly those with a history of prematurity or congenital heart disease, are at greater risk for unfavorable sequelae when infected with a respiratory virus (27). In this study, prematurity was found in one patient and co-morbidities were noticed in two patients, including cardiac disorder in one patient (25%) and allergy in the other one (25%).…”

Section: Discussionmentioning

confidence: 62%

Human Metapneumovirus Pediatric Respiratory Infections: Comparing Direct Immunofluorescence versus Polymerase Chain Reaction

El-Wakil

El-Seidi

Dwedar

et al. 2016

Arch Pediatr Infect Dis

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Poor Outcome of Acute Respiratory Infection in Young Children with Underlying Health Condition in Brazil

Abstract: Identification of this high-risk population along with strategies for fast diagnosis might each help to reduce morbidity and mortality in this group.

Cited by 16 publications

References 30 publications

Typical epidemiology of respiratory virus infections in a Brazilian slum

Typical epidemiology of respiratory virus infections in a Brazilian slum

Comparison of viral and epidemiological profiles of hospitalized children with severe acute respiratory infection in Beijing and Shanghai, China

Human Metapneumovirus Pediatric Respiratory Infections: Comparing Direct Immunofluorescence versus Polymerase Chain Reaction

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