Poor late prognosis of bleeding peptic ulcer

Abstract

Long-term prognosis of peptic ulcer bleeding is poor! The majority of deaths after hospital stay is probably not because of ulcer bleeding, but because of more aged patients with severe concomitant diseases.

The excess long-term mortality in peptic ulcer bleeding is explained by nonspecific comorbidity

“…In accordance with previous studies [2][3][4][5][6][7][8], we observed that the long-term mortality was higher in PUB patients than in an age-and sex-matched control cohorts. Unfortunately, it is not possible to establish a well-defined focus area to mitigate the high long-term mortality in PUB patients.…”

“…For reasons that are not fully understood, PUB is also associated with an excess long-term mortality, lasting many years after the bleeding episode has been managed [2][3][4][5][6][7][8]. The cause of long-term mortality in patients surviving an episode with PUB seems to be competing diseases as cancer, cardiovascular, or respiratory diseases, rather than recurrence of PUB [3,[5][6][7]9].…”

Systematic Review of the Epidemiology of Complicated Peptic Ulcer Disease: Incidence, Recurrence, Risk Factors and Mortality

“…tables 5 and 6) [12,15,39,46,51,59,60,61,62,63,64,65,66,67]. In most cases, this increase in mortality was associated with age over 60 years.…”

Chronic liver disease and 90-day mortality in 21 359 patients following peptic ulcer bleeding - a Nationwide Cohort Study

“…Chronic liver disease increases the risk of peptic ulcer bleeding, a serious and frequent medical emergency with reported incidence ranging from 0.47 to 0.57 per 1000 person‐years . Despite improvements in peri‐operative management, post‐operative care, and adjuvant pharmacological treatment, mortality rates remain elevated, with reported 30‐day mortality as high as 12% …”

“…[4][5][6][7] Despite improvements in peri-operative management, post-operative care, and adjuvant pharmacological treatment, mortality rates remain elevated, with reported 30-day mortality as high as 12%. [8][9][10][11][12][13] Comorbidity may contribute to mortality from peptic ulcer bleeding. 12,[14][15][16][17] In particular, liver disease may result in disturbances in coagulation and susceptibility to hypovolaemic shock and infection.…”