Poor Clinical Outcome for Meningitis Caused by<i>Haemophilus influenzae</i>Serotype A Strains Containing the IS<i>1016‐bexA</i>Deletion

Lima, Josilene Borges Torres; Ribeiro, Guilherme S.; Cordeiro, Soraia Machado; Gouveia, Edilane Lins; Salgado, Kaátia; Spratt, Brian G.; Godoy, Daniel; Reis, Mitermayer Galvão dos; Ko, Albert I.; Reis, Joice Neves

doi:10.1086/656778

Cited by 33 publications

(26 citation statements)

References 36 publications

(60 reference statements)

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“…Of the 13 Alaska Native children infected during the 2009–2011 outbreak, 6 (46%) had meningitis, 1 (8%) child died, and 1 child had serious neurologic complications following a stroke the child experienced in the hospital. Although clinical disease associated with Hia was often severe, the Hia isolates from this outbreak in Alaska do not exhibit the IS 1016 -bexA partial deletion, a characteristic classically associated with more severe disease ( 12 , 25 ). …”

Section: Discussionmentioning

confidence: 82%

Haemophilus influenzae Serotype a Invasive Disease, Alaska, USA, 1983–2011

Bruce¹,

Zulz²,

DeByle³

et al. 2013

Emerg. Infect. Dis.

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Before introduction of Haemophilus influenzae type b (Hib) vaccines, rates of Hib disease in Alaska’s indigenous people were among the highest in the world. Vaccination reduced rates dramatically; however, invasive H. influenzae type a (Hia) disease has emerged. Cases of invasive disease were identified through Alaska statewide surveillance during1983–2011. Of 866 isolates analyzed for serotype, 32 (4%) were Hia. No Hia disease was identified before 2002; 32 cases occurred during 2002–2011 (p<0.001). Median age of case-patients was 0.7 years; 3 infants died. Incidence of Hia infection (2002–2011) among children <5 years was 5.4/100,000; 27 cases occurred in Alaska Native children (18/100,000) versus 2 cases in non-Native children (0.5/100,000) (risk ratio = 36, p<0.001). From 12/2009 to 12/2011, 15 cases of Hia disease occurred in southwestern Alaska (in children <5 years, rate = 204/100,000). Since introduction of the Hib conjugate vaccine, Hia infection has become a major invasive bacterial disease in Alaska Native children.

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Section: Discussionmentioning

confidence: 82%

Haemophilus influenzae Serotype a Invasive Disease, Alaska, USA, 1983–2011

Bruce¹,

Zulz²,

DeByle³

et al. 2013

Emerg. Infect. Dis.

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“…Both cases of Hia meningitis reported in the present study required hospitalization and long-term antibiotic therapy; furthermore, both children cleared the infection with some persistent seizure activity and developmental issues. Lima et al (25) reported poorer outcomes in Hia meningitis caused by strains having the IS1016-bexA partial deletion. Both isolates lacked this deletion and were also negative for β-lactamase and that may explain the success in treatment.…”

Section: Discussionmentioning

confidence: 99%

Emergence of Non-Serotype b EncapsulatedHaemophilus influenzaeas a Cause of Pediatric Meningitis in Northwestern Ontario

Sadeghi-Aval

Tsang

Ulanova

2013

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Before the introduction of the conjugate vaccine, Haemophilus influenzae serotype b (Hib) was the leading cause of bacterial meningitis in children. Although successful in reducing Hib cases, the vaccine confers no protection against other serotypes of H influenzae, such as a (Hia), or f (Hif). The emergence of invasive disease caused by non-Hib in northwestern Ontario (38 cases between 2002 and 2008) with predominance of Hia was previously reported by the authors. At that time, no cases of pediatric meningitis caused by H influenzae were recorded in the region. Continued surveillance identified 12 new cases of invasive non-Hib between January 2009 and July 2011. Among these cases, three young children developed meningitis with severe complications caused by Hia or Hif. The present article describes these cases along with the characteristics of recent H influenzae isolates from the region, (ie, their genetic background and antibiotic sensitivity). The findings point to the clonal nature of circulating Hia strains as well as to an increase in frequency and severity of pediatric invasive H influenzae infections in northwestern Ontario.

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“…The isolates characterized in this study were originally collected as part of three separate studies of meningitis and communityacquired UTI that occurred in Salvador, Brazil (26,27). Due to sample loss, only a subset of the UTI isolates were characterized.…”

Section: Methodsmentioning

confidence: 99%

“…As part of an ongoing study of the etiology of meningitis, limited epidemiologic information is recorded, and bacterial isolates are collected from this reference laboratory and then biobanked at the Gonçalo Moniz Research Center. The methodology and results of this study were previously published (27).…”

Section: Methodsmentioning

confidence: 99%

Distribution of Strain Type and Antimicrobial Susceptibility of Escherichia coli Isolates Causing Meningitis in a Large Urban Setting in Brazil

et al. 2014

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The clinical management of meningitis caused by Escherichia coli is greatly complicated when the organism becomes resistant to broad-spectrum antibiotics. We sought to characterize the antimicrobial susceptibilities, sequence types (ST), and presence of known drug resistance genes of E. coli isolates that caused meningitis between 1996 and 2011 in Salvador, Brazil. We then compared these findings to those for E. coli isolates from community-acquired urinary tract infections (UTI) that occurred during the same time period and in the same city. We found that 19% of E. coli isolates from cases of meningitis and less than 1% of isolates from UTI were resistant to third-generation cephalosporins. The sequence types of E. coli isolates from cases of meningitis included ST131, ST69, ST405, and ST62, which were also found among isolates from UTI. Additionally, among the E. coli isolates that were resistant to third-generation cephalosporins, we found genes that encode the extended-spectrum beta-lactamases CTX-M-2, CTX-M-14, and CTX-M-15. These observations demonstrate that compared to E. coli strains isolated from cases of community-acquired UTI, those isolated from cases of meningitis are more resistant to third-generation cephalosporins, even though the same sequence types are shared between the two forms of extraintestinal infections.

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Poor Clinical Outcome for Meningitis Caused byHaemophilus influenzaeSerotype A Strains Containing the IS1016‐bexADeletion

Cited by 33 publications

References 36 publications

Haemophilus influenzae Serotype a Invasive Disease, Alaska, USA, 1983–2011

Haemophilus influenzae Serotype a Invasive Disease, Alaska, USA, 1983–2011

Emergence of Non-Serotype b EncapsulatedHaemophilus influenzaeas a Cause of Pediatric Meningitis in Northwestern Ontario

Distribution of Strain Type and Antimicrobial Susceptibility of Escherichia coli Isolates Causing Meningitis in a Large Urban Setting in Brazil

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