Poor chemotherapy-induced nausea and vomiting control in children receiving intermediate or high dose methotrexate

Abstract

The poor complete CINV control rate in children receiving methotrexate confirms the classification of HD-MTX as highly emetogenic chemotherapy (HEC) and suggests that ID-MTX be reclassified as HEC.

Risk Factors Associated With Chemotherapy-Induced Nausea in the Week Before the Next Cycle and Impact of Nausea on Quality of Life Outcomes

“…In three studies, 2e4 younger than 50 years was associated with increased risk for CIN, whereas in two studies, 5,6 no age association was found. Similarly, in three studies, 2,3,5 female patients were more likely to report CIN, whereas in three studies, 2,6,7 no association was reported.…”

Smartphone App to Self-Monitor Nausea During Pediatric Chemotherapy Treatment: User-Centered Design Process

“…Nausea has a higher incidence than vomiting during administration of chemotherapy, but it is a challenge to recognize subjective symptoms such as nausea in children. Furthermore, children under 4 years of age are often excluded from studies that investigate the burden of chemotherapy-induced nausea and vomiting in children [ 32 - 34 ]. The target users of this app are children aged 0 to 18 years (and their parents) undergoing cancer treatment.…”

Acupressure bands do not improve chemotherapy‐induced nausea control in pediatric patients receiving highly emetogenic chemotherapy: A single‐blinded, randomized controlled trial

“…Evaluation of CIN in pediatric patients has only recently been possible through the development and validation of pediatric, self‐report measures like the Pediatric Nausea Assessment Tool (PeNAT) . Recent studies indicate that almost all pediatric patients receiving highly emetogenic chemotherapy (HEC) experience CIN …”

“…2 Recent studies indicate that almost all pediatric patients receiving highly emetogenic chemotherapy (HEC) experience CIN. 3,4 Many patients and families are interested in using nonpharmacologic therapies to control symptoms. 5 Acupuncture and acupressure are traditional Chinese medicine techniques that seek to improve health by regulating basal energy through acupoint stimulation.…”