Poor airway function in early infancy and lung function by age 22 years: a non-selective longitudinal cohort study

Stern, Debra A.; Morgan, Wayne J.; Wright, Anne L.; Guerra, Stefano; Martínez, Fernando D.

doi:10.1016/s0140-6736(07)61379-8

Cited by 516 publications

(452 citation statements)

References 43 publications

(28 reference statements)

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“…There is increasing evidence that lung function ''tracks'' from birth into infancy and childhood, and from childhood into adulthood [6,[24][25][26][27]. In our study, a relationship between infant lung function and spirometry at 5 years of age was also found.…”

Section: Discussionsupporting

confidence: 69%

Reduced neonatal lung function and wheezing illnesses during the first 5 years of life

et al. 2012

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Studies of reduced neonatal lung function and wheezing illnesses during childhood show conflicting results. The aim of our study was to assess the association between resistance (Rrs) and compliance (Crs) of the respiratory system by using the single occlusion technique (SOT) and prospectively collected wheezing illnesses during the first 5 years of life in a large birth cohort.SOT was performed during natural sleep before the age of 2 months. Information about wheezing illnesses was collected from the electronic patient file.549 infants had a successful SOT measurement and complete medical records. Every kPa?L -1 ?s -1 increase in Rrs was associated with 10% more consultations in the first 3 years of life. Every 10 mL?kPa -1 increase in Crs was associated with a 14% reduction in consultations in the first 3 years of life, 27% in the fourth to fifth years of life, and a lower probability of having asthma at the age of 5 years (OR 0.66). Children with lateonset or persistent wheezing had significant lower Crs values than their peers.An increased neonatal resistance is associated with more wheezing illnesses during infancy, while a reduced neonatal compliance is associated with more wheezing illnesses during the first 5 years of life, a late-onset or persistent wheezing phenotype, and asthma. @ERSpublications Increased neonatal resistance and reduced neonatal compliance are both associated with more wheezing illnesses

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Section: Discussionsupporting

confidence: 69%

Reduced neonatal lung function and wheezing illnesses during the first 5 years of life

et al. 2012

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“…Longitudinal cohort studies have shown that lung function trajectories are set in early life with a developmental window of susceptibility, which can be disrupted by both infectious and environmental exposures [10,90,91]. Maternal smoking reduces infant lung function which is associated with impaired lung volume in adulthood (both for FEV1 and forced vital capacity (FVC)), independent of smoking in adulthood, compounding the effect of smoking to reduce airflow limitation and increasing the risk of COPD [92].…”

Section: Resultsmentioning

confidence: 99%

The association between environmental tobacco smoke exposure and childhood respiratory disease: a review

Vanker

Gie

Zar

2017

Expert Review of Respiratory Medicine

136

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Introduction: Childhood respiratory illness is a major cause of morbidity and mortality particularly in low and middle-income countries. Environmental tobacco smoke (ETS) exposure is a recognised risk factor for both acute and chronic respiratory illness.Areas covered: The aim of this paper was to review the epidemiology of ETS exposure and impact on respiratory health in children. We conducted a search of 3 electronic databases of publications on ETS and childhood respiratory illness from 1990–2015. Key findings were that up to 70% of children are exposed to ETS globally, but under-reporting may mask the true prevalence. Maternal smoking and ETS exposure influence infant lung development and are associated with childhood upper and lower respiratory tract infection, wheezing or asthma. Further, exposure to ETS is associated with more severe respiratory disease. ETS exposure reduces lung function early in life, establishing an increased lifelong risk of poor lung health.Expert commentary: Urgent and effective strategies are needed to decrease ETS exposure in young children to improve child and long-term lung health in adults especially in low and middle income countries where ETS exposure is increasing.

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“…Studies involving children and young adults have shown that the most important determinant of maximally attained lung function later in life was the lung-function value at a younger age. [26][27][28][29] Svanes et al observed that childhood risk factors such as maternal smoking, childhood respiratory infections, and childhood asthma were strongly related to the development of COPD in young adults. 30 Nevertheless, although our results highlight the important role of maximally attained lung function in early adulthood, Shown is the distribution of observed annual decline in forced expiratory volume in 1 second (FEV 1 ) among 2864 participants in the Framingham Offspring Cohort (FOC) and the Copenhagen City Heart Study (CCHS), according to the four trajectories defined on the basis of a normal FEV 1 (≥80% of the predicted value) or low FEV 1 (<80% of the predicted value) at baseline and the presence or absence of chronic obstructive pulmonary disease (COPD) at the final examination.…”

Section: Discussionmentioning

confidence: 99%

Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease

et al. 2015

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BACKGROUNDChronic obstructive pulmonary disease (COPD) is thought to result from an accelerated decline in forced expiratory volume in 1 second (FEV 1 ) over time. Yet it is possible that a normal decline in FEV 1 could also lead to COPD in persons whose maximally attained FEV 1 is less than population norms. METHODSWe stratified participants in three independent cohorts (the Framingham Offspring Cohort, the Copenhagen City Heart Study, and the Lovelace Smokers Cohort) according to lung function (FEV 1 ≥80% or <80% of the predicted value) at cohort inception (mean age of patients, approximately 40 years) and the presence or absence of COPD at the last study visit. We then determined the rate of decline in FEV 1 over time among the participants according to their FEV 1 at cohort inception and COPD status at study end. RESULTSAmong 657 persons who had an FEV 1 of less than 80% of the predicted value before 40 years of age, 174 (26%) had COPD after 22 years of observation, whereas among 2207 persons who had a baseline FEV 1 of at least 80% of the predicted value before 40 years of age, 158 (7%) had COPD after 22 years of observation (P<0.001). Approximately half the 332 persons with COPD at the end of the observation period had had a normal FEV 1 before 40 years of age and had a rapid decline in FEV 1 thereafter, with a mean (±SD) decline of 53±21 ml per year. The remaining half had had a low FEV 1 in early adulthood and a subsequent mean decline in FEV 1 of 27±18 ml per year (P<0.001), despite similar smoking exposure. CONCLUSIONSOur study suggests that low FEV 1 in early adulthood is important in the genesis of COPD and that accelerated decline in FEV 1 is not an obligate feature of COPD. (Funded by an unrestricted grant from GlaxoSmithKline and others.) a bs tr ac t

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Poor airway function in early infancy and lung function by age 22 years: a non-selective longitudinal cohort study

Abstract: Background-Together with smoking, the level of lung function attained in early adulthood is among the strongest predictors of chronic obstructive pulmonary disease. Whether airway function measured shortly after birth is a determinant of this level is currently unknown.

Cited by 516 publications

References 43 publications

Reduced neonatal lung function and wheezing illnesses during the first 5 years of life

Reduced neonatal lung function and wheezing illnesses during the first 5 years of life

The association between environmental tobacco smoke exposure and childhood respiratory disease: a review

Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease

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