Pools of independently cycling inositol phosphates revealed by pulse labeling with18O-water
G. Kim,
G. Liu,
D. Qiu
et al.
Abstract:Inositol phosphates control many central processes in eukaryotic cells, including nutrient availability, growth, and motility. Kinetic resolution of a key modulator of their signaling functions, the turnover of the phosphate groups on the inositol ring, has been hampered by slow uptake, high dilution, and constraining growth conditions in radioactive pulse-labeling approaches. Here, we demonstrate rapid (seconds to minutes), non-radioactive labeling of inositol polyphosphates through 18O-water in yeast, amoeba… Show more
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