Pooled reanalysis of cancer mortality among five cohorts of workers in wood-related industries

Demers, Paul A.; Boffetta, Paolo; Kogevinas, Manolis; Blair, Aaron; Miller, Barry A.; Robinson, CF; Roscoe, RJ; Winter, P D; Colin, Didier; Matos, Elena; Vainio, Harri

doi:10.5271/sjweh.26

Cited by 109 publications

(74 citation statements)

References 32 publications

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“…20 -24 The association seemed stronger for adenocarcinoma. 25 With an exception of a few studies, 23,26 nasopharyngeal cancer is generally not associated with wood-related work. A given occupation may also expose its workers to carcinogens other than that under study.…”

Section: Discussionmentioning

confidence: 99%

Case‐control study evaluating the homogeneity and heterogeneity of risk factors between sinonasal and nasopharyngeal cancers

Zhu

Levine

Brann

et al. 2002

Intl Journal of Cancer

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Sinonasal cancer and nasopharyngeal cancer may share some risk factors because both are located within the upper aerodigestive tract. They may also have different etiological profiles because of anatomic or pathologic differences. However, the similarities and differences in risk factors have rarely been studied within the same population. We assessed the risk factor profiles of sinonasal and nasopharyngeal cancers, using data from a case-control study. The 2 case groups consisted of men aged 31-59 and diagnosed pathologically with sinonasal cancer (n‫)07؍‬ and nasopharyngeal cancer (n‫,)311؍‬ respectively. Controls were men without these cancers and selected from the same areas (n‫.)0191؍‬ Logistic regression analysis showed that smoking was a risk factor for both sinonasal [odds ratio (OR)‫,5.2؍‬ 95% confidence interval (CI) 1.1-5.4] and nasopharyngeal cancer (OR‫,8.1؍‬ 95%CI 1.1-3.0). However, ever use of barbiturates without a prescription (OR‫,9.4؍‬ 95%CI 1.7-13.8), working with or around cutting oils on a job (OR‫,9.1؍‬ 95%CI 1.1-3.1) and ever having had sinus infections (OR‫,3.2؍‬ 95%CI 1.1-4.6) were associated with nasopharyngeal cancer only. Having received blood products other than a transfusion (OR‫,1.9؍‬ 95%CI 2.2-37.4) and exposure to a pesticide containing 2,4,5-T (OR‫,9.5؍‬ 95%CI 1.5-23.7) were related to sinonasal cancer only. When data analyses were confined to squamous cell type, smoking and exposure to chlorophenols were related to squamous cell tumors at both sites. However, use of barbiturates and sinus problems other than infection only increased the risk of nasopharyngeal carcinoma. Our study suggests that except for smoking and chlorophenol exposure, which are associated with both sites, the risk factor profiles may differ between sinonasal and nasopharyngeal cancers. © 2002 Wiley-Liss, Inc. Key words: case-control studies; nasopharyngeal cancer; risk factors; sinonasal cancer; smokingContiguous sites within a system may be prone to the effect of the same risk factors for cancer because of their common exposures. However, the sites within a system usually differ in anatomical or histologic features and therefore may have different susceptibility to different etiological factors, resulting in different risk factor profiles. Sinonasal cancer (malignancies of the sinus or nasal cavities) and nasopharyngeal cancer (malignancies of the nasopharynx) may share some risk factors because both are located within the upper aerodigestive tract. They may also possess different epidemiological and etiological profiles because of anatomic or pathologic differences. It is known that sinonasal cancer occurs more frequently in individuals in their 60s and in some areas in Japan, France, India and South Africa, 1 while nasopharyngeal cancer is more frequent in Southern China and some African tribes and incidence rates reach a peak during adolescence or during ages 45-55. 2,3 Studies in different regions and different populations have identified distinct risk-factor profiles for sinonasal and nasopharyngeal ...

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Section: Discussionmentioning

confidence: 99%

Case‐control study evaluating the homogeneity and heterogeneity of risk factors between sinonasal and nasopharyngeal cancers

Zhu

Levine

Brann

et al. 2002

Intl Journal of Cancer

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“…131 The majority of studies, however, do not report significant associations, with point estimates at, below or above unity. 28,43,89,90,131,154,223,[243][244][245] Findings among workers exposed to fresh wood, wood dust or those in lumber or wood production have been inconsistent, with some case-control studies reporting excess risks, 28,43,44,90,109,131,246 and others reporting risk deficits. 88,89,154,247 In a follow-up study among Swedish construction workers, Lee et al 243 reported a relative risk of 0.8 (95% CI: 0.49-1.23) for wood dust exposure (ever vs. never), whereas Demers et al 246 reported a nonsignificant increased risk for definite wood dust exposure among wood workers (SMR 5 1.6, 95% CI: 0.8-2.8).…”

Section: Other Occupational and Environmental Factorsmentioning

confidence: 99%

Multiple myeloma: A review of the epidemiologic literature

et al. 2007

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Multiple myeloma, a neoplasm of plasma cells, accounts for 15% of lymphatohematopoietic cancers (LHC) and 2% of all cancers in the US. Incidence rates increase with age, particularly after age 40, and are higher in men, particularly African American men. The etiology is unknown with no established lifestyle, occupational or environmental risk factors. Although several factors have been implicated as potentially etiologic, findings are inconsistent. We reviewed epidemiologic studies that evaluated lifestyle, dietary, occupational and environmental factors; immune function, family history and genetic factors; and the hypothesized precursor, monoclonal gammopathies of undetermined significance (MGUS). Because multiple myeloma is an uncommon disease, etiologic assessments can be difficult because of small numbers of cases in occupational cohort studies, and few subjects reporting exposure to specific agents in case-control studies. Elevated risks have been reported consistently among persons with a positive family history of LHC. A few studies have reported a relationship between obesity and multiple myeloma, and this may be a promising area of research. Factors underlying higher incidence rates of multiple myeloma in African Americans are not understood. The progression from MGUS to multiple myeloma has been reported in several studies; however, there are no established risk factors for MGUS. To improve our understanding of the causes of multiple myeloma, future research efforts should seek the causes of MGUS. More research is also needed on the genetic factors of multiple myeloma, given the strong familial clustering of the disease. ' 2007 Wiley-Liss, Inc.Key words: multiple myeloma; epidemiology Multiple myeloma is a malignancy of plasma cells that results in an overproduction of light and heavy chain monoclonal immunoglobulins. The specific immunoglobulin secreted by the malignant cell is the M-protein, named in reference to its monoclonal characteristics. It is found in the serum and/or urine of persons affected with multiple myeloma.

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“…20 Asbestos is not causally associated with NHL, as relative risk estimates across studies are generally near 1.0. 29,31,117,170,176,239,240 Findings among persons exposed to wood or leather dusts are inconsistent, with relative risk estimates both above 20,21,31,71,202,[241][242][243] and below 1.0. 31,35,71,170,176,200,244,245 One NHL death (2.4 expected) was observed in a study of workers exposed to creosote at 11 woodtreating plants in the US, 246 there was no significant excess of lymphosarcoma among US pulp and paper mill workers (SMR 5 1.19, 95% CI: 0.81-1.69).…”

Section: Occupational and Environmental Chemical Exposurementioning

confidence: 99%