Ponderal index at birth associates with later risk of gestational diabetes mellitus

Crusell, Mie; Damm, Peter; Hansen, Torben; Pedersen, Oluf; Glümer, Charlotte; Vaag, Allan; Lauenborg, Jeannet

doi:10.1007/s00404-017-4427-4

Cited by 9 publications

(8 citation statements)

References 30 publications

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“…Similar to previous studies that have shown birth weight to be inversely associated with risk for GDM [16–18, 29, 30], and a more recent study from 2017 that reported ponderal index to be inversely associated with GDM [22], we also found an increased risk for GDM in women with a small BSA at birth and a lower risk for women with a large BSA at birth. However, we did not detect a similar statistically significant relationship between ponderal index and risk for GDM.…”

Section: Discussionsupporting

confidence: 90%

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Body surface area at birth and later risk for gestational diabetes mellitus among primiparous women

et al. 2018

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AimsTo assess the relationship between body surface area (BSA) at birth and future risk for gestational diabetes mellitus (GDM).MethodsThis is an observational cohort study from Vantaa, Finland. The cohort included 1548 Finnish primiparous women, aged 15–28 years, without pre-existing diabetes, who gave birth 2009–2015. All women were born full-term and had complete information about their birth weight and length, from the Finnish Medical Birth Register. Additional data for the study were provided by individual patient health records and Statistics Finland. Study participants were divided into five levels (I–V) according to BSA at birth, based on normal distribution.ResultsThere was an inverse association between BSA at birth and risk for GDM (p = 0.015 for linearity, after adjustments for age, educational attainment, pre-pregnancy BMI and smoking). The odds ratio (OR) for GDM in level V, with the largest BSA at birth, compared with level I, with the smallest BSA at birth, was 0.43 [95% confidence interval (CI) 0.22–0.83]; adjusted for age, educational attainment, pre-pregnancy body mass index and smoking. The OR for GDM was 0.8 (95% CI 0.68–0.95, p = 0.009) for each one standard deviation increase in BSA at birth, adjusted for the same confounders. BSA at birth correlated with adult anthropometry: correlation coefficients were r = 0.16 (95% CI 0.11–0.21) for weight, r = 0.31 (95% CI 0.26–0.35) for height, and r = 0.06 (95% CI 0.01–0.11) for BMI.ConclusionsBody surface area at birth is inversely associated with future risk for GDM in primiparous women.

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Section: Discussionsupporting

confidence: 90%

“…However, birth weight is a very crude measurement of body size at birth. Interestingly, only one recent study has assessed the relationship between maternal birth size using ponderal index (PI) as a measurement of body size at birth and risk for GDM, showing an inverse association [22]. …”

Section: Introductionmentioning

confidence: 99%

Body surface area at birth and later risk for gestational diabetes mellitus among primiparous women

et al. 2018

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“…Although PI may not be a better indicator of foetal morbidity 13 than BW, it reflects potential asymmetric growth due to a nonoptimal periconceptional environment as well as neonatal fat mass 19 . Additionally, variations in PI have been associated with adverse long-term consequences 20 . The multivariate analyses performed here show that a high PI at birth is an infertility risk factor in adulthood.…”

Section: Discussionmentioning

confidence: 99%

Female ponderal index at birth and idiopathic infertility

Dupont

Hulot

Jaffrézic

et al. 2019

J Dev Orig Health Dis

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Epidemiological studies have demonstrated an increased risk of developing non-transmittable diseases in adults subjected to adverse early developmental conditions. Metabolic and cardiovascular diseases have been the focus of most studies. Nevertheless, data from animal models also suggest early programming of fertility. In humans, it is difficult to assess the impact of the in utero environment retrospectively. Birthweight is commonly used as an indirect indicator of intrauterine development. This research is part of the ALIFERT study. We investigated a potential link between ponderal index at birth and female fertility in adulthood. Data from 51 infertile and 74 fertile women were analysed. BW was on average higher in infertile women, whereas birth length did not differ between the two groups; thus, resulting in a significantly higher ponderal index at birth in infertile women. Ponderal index at birth has been identified as a risk factor for infertility. These results suggest the importance of the intra-uterine environment, not only for long-term metabolic health but also for fertility.

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“…Birth weight was recorded in 100 g groups and analyzed in three categories: ≤2500 low birth weight; 2500–4000 normal birth weight; and ≥4000 g high birth weight. Ponderal index, calculated as birth weight [Kg]/birth length [meters] 3 , was also included as it is theoretically assumed to measure fetal growth and thereby discriminate between intra-uterine well-fed (high ponderal index) and disproportionate growth restricted newborns (low ponderal index) [40]. Ponderal index was analyzed as three-category variable (1 st quintile; 2 nd -4 th quintile; 5th quintile).…”

Section: Methodsmentioning

confidence: 99%

Birth dimensions, severe mental illness and risk of type 2 diabetes in a cohort of Danish men born in 1953

Garriga

Wium‐Andersen

et al. 2019

Eur. psychiatr.

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Background: Birth dimensions have been associated with increased risk of both, severe mental illness and type 2 diabetes in adulthood, however, any influence on their co-occurrence has never been examined. This cohort study examine whether birth weight/ponderal index explain or modify the later association between severe mental illness and risk of type 2 diabetes. Methods: The Metropolit cohort included 10,863 Danish men born in 1953 with information from age at conscription (between1971-84) until February 15th, 2018. Severe mental illness was defined as the exposure and information was retrieved from the national Danish health registries. Information on type 2 diabetes diagnosis or oral antidiabetic prescriptions was also obtained, as they were the outcome of interest. Information on birth weight/ponderal index was available from birth certificates. Cox proportional hazards regression models were used to estimate the associations and interactions were tested. Results: After 47.1 years of follow-up, 848 (7.8%) and 1320 (12.2%) men developed a severe mental illness or diabetes, respectively. Men with severe mental illness presented higher risk of subsequent diabetes (HR = 1.92; 95%CI, 1.61–2.30). This association was stronger in severe mental ill men with low birth weight (HR = 3.58; 95%CI, 2.11–6.07), than in those normal birth weight (HR = 1.79; 95%CI, 1.45–2.20). This effect modification was most evident for men diagnosed with schizophrenia. Conclusions: Birth information on birth weight/ponderal index could be of interest in diabetes screening on severe mental ill populations (especially in schizophrenia) since they might play a critical role in the increased risk of type 2 diabetes following severe mental illness.

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Ponderal index at birth associates with later risk of gestational diabetes mellitus

Cited by 9 publications

References 30 publications

Body surface area at birth and later risk for gestational diabetes mellitus among primiparous women

Body surface area at birth and later risk for gestational diabetes mellitus among primiparous women

Female ponderal index at birth and idiopathic infertility

Birth dimensions, severe mental illness and risk of type 2 diabetes in a cohort of Danish men born in 1953

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