PON1Q192R polymorphism is associated with lipid profile in Mexican men with Mayan ascendancy

Pérez-Herrera, Norma; May-Pech, Carlos; Hernández‐Ochoa, Isabel; Castro-Mañé, Jorge; Rojas‐García, Elizabeth; Borja-Aburto, Víctor Hugo; Castillo-Burguete, Teresa; Quintanilla‐Vega, Betzabet

doi:10.1016/j.yexmp.2008.05.003

Cited by 26 publications

(19 citation statements)

References 38 publications

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“…In fact, the antioxidant activity and anti-atherogenic effect of HDL is thought to be largely because of the paraoxonase located on the HDL particle. Variants in PON1 previously have been associated with serum HDL and LDL cholesterol levels [51,52], and with increased risk for stroke [53]. There have been multiple studies and meta-analyses evaluating the association of PON1 variants with blood lipids in several populations or community-based samples, but with inconsistent results [51,54-61].…”

Section: Discussionmentioning

confidence: 99%

Genetic variants associated with fasting blood lipids in the U.S. population: Third National Health and Nutrition Examination Survey

et al. 2010

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BackgroundThe identification of genetic variants related to blood lipid levels within a large, population-based and nationally representative study might lead to a better understanding of the genetic contribution to serum lipid levels in the major race/ethnic groups in the U.S. population.MethodsUsing data from the second phase (1991-1994) of the Third National Health and Nutrition Examination Survey (NHANES III), we examined associations between 22 polymorphisms in 13 candidate genes and four serum lipids: high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TG). Univariate and multivariable linear regression and within-gene haplotype trend regression were used to test for genetic associations assuming an additive mode of inheritance for each of the three major race/ethnic groups in the United States (non-Hispanic white, non-Hispanic black, and Mexican American).ResultsVariants within APOE (rs7412, rs429358), PON1 (rs854560), ITGB3 (rs5918), and NOS3 (rs2070744) were found to be associated with one or more blood lipids in at least one race/ethnic group in crude and adjusted analyses. In non-Hispanic whites, no individual polymorphisms were associated with any lipid trait. However, the PON1 A-G haplotype was significantly associated with LDL-C and TC. In non-Hispanic blacks, APOE variant rs7412 and haplotype T-T were strongly associated with LDL-C and TC; whereas, rs5918 of ITGB3 was significantly associated with TG. Several variants and haplotypes of three genes were significantly related to lipids in Mexican Americans: PON1 in relation to HDL-C; APOE and NOS3 in relation to LDL-C; and APOE in relation to TC.ConclusionsWe report the significant associations of blood lipids with variants and haplotypes in APOE, ITGB3, NOS3, and PON1 in the three main race/ethnic groups in the U.S. population using a large, nationally representative and population-based sample survey. Results from our study contribute to a growing body of literature identifying key determinants of plasma lipoprotein concentrations and could provide insight into the biological mechanisms underlying serum lipid and cholesterol concentrations.

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Section: Discussionmentioning

confidence: 99%

Genetic variants associated with fasting blood lipids in the U.S. population: Third National Health and Nutrition Examination Survey

et al. 2010

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“…The study determined that for this population, the R allele of the PON1 Q192R polymorphism was not an independent risk factor for the development of myocardial infarction (p<0.005) (46). Gamboa et al (13), Pérez-Herrera et al (47), Rojas-García et al (48), and other studies in Chinese, Afro-American, and other Mexican populations demonstrated that individuals with the PON1 192RR genotype had lower levels of HDL cholesterol than 192QQ genotype carriers. These results are similar to those in our control group.…”

Section: Introductionmentioning

confidence: 90%

Polymorphisms of lipid metabolism enzyme-coding genes in patients with diabetic dyslipidemia

Vardarlı

Harman²,

Çetintaş³

et al. 2017

Anatol J Cardiol

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Objective:The polymorphisms/mutations of genes encoding proteins and enzymes involved in lipoprotein metabolism play important roles in the development of diabetic dyslipidemia. The aim of our study was to investigate the effects of LPL (rs320), LIPC (rs2070895), SCARB1 (rs5888), LCAT (rs2292318), CETP (rs708272), ADIPOQ (rs1501299), RETN (rs3745367), PON1 (rs662), and MNSOD (rs4880) gene polymorphisms on lipid metabolism and diabetic dyslipidemia.Methods:This case-control study included 217 patients with diabetic dyslipidemia and 212 healthy age- and gender-matched individuals. Genomic DNA isolation was performed from blood samples, and genotype analysis was performed using melting curve analysis on a LightCycler® 480 Instrument. The chi-square test was used to compare genotype distribution and allele frequencies between the groups.Results:Significant associations were observed between LPL (rs320) (p<0.001), LIPC (rs2070895) (p<0.001), SCARB1 (rs5888) (p<0.001), LCAT (rs2292318) (p<0.001), CETP (rs708272) (p<0.001), ADIPOQ (rs1501299) (p=0.01), RETN (rs3745367) (p<0.001), and MNSOD (rs4880) (p<0.001) polymorphisms and diabetic dyslipidemia. However, no association was observed between PON1 (rs662) polymorphisms and diabetic dyslipidemia (p=0.611).Conclusion:LPL (rs320), LIPC (rs2070895), SCARB1 (rs5888), LCAT (rs2292318), CETP (rs708272), ADIPOQ (rs1501299), RETN (rs3745367), and MNSOD (rs4880) polymorphisms play an important role in basic molecular metabolism in diabetic dyslipidemia. Therefore, these polymorphisms may be used as a predictive marker for diabetic dyslipidemia in high-risk patients. (Anatol J Cardiol 2017; 17: 313-21)

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“…Após a sua descoberta, a PON tem sido objeto de estudo em diversos campos de pesquisa (Van Himbergen et al, 2006;Goswami et al, 2009). Assim, a família PON pode estar associada a inúmeros eventos fisiopatológicos como doença aterosclerótica coronariana (Pérez-Herrera et al, 2008;Shin, 2009;Précourt et al, 2011), síndrome metabólica (Flekac et al, 2008;Kordi-Tamandani et al, 2011) e distúrbios neurológicos (Lawlor et al, 2007;Kucukali et al, 2008).…”

Section: Paraoxonase (Pon)unclassified

“…O substrato paroxon é eficientemente hidrolisado pela aloenzima 192R (Li et al, 2000;Draganov e La Du, 2004) e outros substratos como soman, sarin e diazoxon são mais rapidamente hidrolisados pela aloenzima 192Q (Humbert et al, 1993;Richter et al, 2009). A isoforma 192Q, in vitro, promove melhor proteção da LDL contra o acúmulo de peróxidos lipídicos Sepahvand et al, 2007) em detrimento da isoforma 192R, a qual, por sua vez, tem sido considerada um fator de risco independente e positivamente associada com a doença coronariana, devido a menor eficácia antioxidativa (Sanghera et al, 1997;Mackness et al,1998;Pérez-Herrera et al, 2008;Vaisi-Raygani et al, 2011).…”

Section: Pon1 E Hdlunclassified

“…O alelo 192Q, no gene da PON1, parece ser mais frequente na população asiática, quando comparado ao alelo 192R (Phuntuwate et al, 2005;Sepahvand et al, 2007;Ozturk et al, 2009;VaisiRaygani et al, 2011), assim como em regiões temperadas da Europa e da América do Norte (Deakin et al, 2003;Hernandez et al, 2003). Achados similares foram também encontrados em alguns estudos realizados na América do Sul (Gamboa et al, 2006;Santos et al, 2005;Maselli, 2007;Pérez-Herrera et al, 2008). Em outros estudos, no entanto, há pouca diferença na distribuição desses alelos ou são inexistentes (Acuña et al, 2004;Rojas-García et al, 2005;Cataño et al, 2006).…”

PON1Q192R polymorphism is associated with lipid profile in Mexican men with Mayan ascendancy

Cited by 26 publications

References 38 publications

Genetic variants associated with fasting blood lipids in the U.S. population: Third National Health and Nutrition Examination Survey

Genetic variants associated with fasting blood lipids in the U.S. population: Third National Health and Nutrition Examination Survey

Polymorphisms of lipid metabolism enzyme-coding genes in patients with diabetic dyslipidemia

Estudo das paraoxonases 1, 2 e 3 em pacientes portadores de anemia falciforme"

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