PON1 Polymorphisms Can Predict Generalized Anxiety and Depressed Mood in Patients with Multiple Chemical Sensitivity

Mosca, Alessio; Casale, Antonio Del; Borro, Marina; Gentile, Giovanna; Pomes, Leda Marina; Padovano, Alessio; Fiaschè, Federica; Pinzone, Vito; Rapinesi, Chiara; Zoppi, Teodolinda; Brugnoli, Roberto; Sani, Gabriele; Kotzalidis, Georgios D.; Girardi, Paolo; Ferracuti, Stefano; Simmaco, Maurizio; Pompili, Maurizio

doi:10.2217/pme-2019-0141

Cited by 4 publications

(3 citation statements)

References 109 publications

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“…The influence of the paraoxonase 1 (PON1) polymorphisms, which affect the formation of ROS/RNS and the immuno-inflammatory characteristics of depression, has also been discussed [ 45 , 46 ]. Similarly, the PON1 polymorphism has been associated with depression and anxiety in individuals who are sensitive to contact with chemicals of nontoxic concentrations [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress Markers and Antioxidant Enzymes in Children and Adolescents with Depressive Disorder and Impact of Omega-3 Fatty Acids in Randomised Clinical Trial

et al. 2021

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Oxidative stress (OS) is thought to play a role in mental disorders. However, it is not clear whether the OS is the cause or consequence of the disorder. We investigated markers of oxidative stress (8-isoprostane (8-IsoP-U), lipoperoxides (LP), advanced oxidation protein products (AOPP) and nitrotyrosine (NT)) and antioxidant protection (Trolox equivalent antioxidant capacity (TEAC), activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) in 60 paediatric and adolescent patients with depressive disorder (DD) compared to healthy controls. The patients were divided into two groups (1:1). One group received an emulsion of omega-3 fatty acid (FA), and the other group an emulsion of sunflower oil with omega-6 FA for 12 weeks. The levels of 8-IsoP-U, AOPP and NT were increased, and GPx activity was decreased in patients compared to the controls. We found a significant positive correlation of the Children’s Depression Inventory score with NT and a negative correlation with TEAC, SOD and GPx. NT correlated positively with the baseline omega-6/omega-3 FA ratio and a negatively with SOD. A supplementation with omega-3 FA, but not with omega-6 FA, decreased 8-IsoP-U, AOPP, NT levels and increased TEAC and SOD activity. Our results suggest that NT may play a role in the pathophysiology of DD, while elevated isoprostane is likely caused by the high omega-6/omega-3 FA ratio. Omega-3 FA supplementation reduces oxidative stress in patients with DD. This study was registered with the ISRCTN registry (ISRCTN81655012).

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Section: Discussionmentioning

confidence: 99%

Oxidative Stress Markers and Antioxidant Enzymes in Children and Adolescents with Depressive Disorder and Impact of Omega-3 Fatty Acids in Randomised Clinical Trial

et al. 2021

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“…The historic lack of understanding of the underlying biomechanisms for CI has inappropriately fostered a view of CI as a psychosomatic disorder (e.g., Multiple Chemical Sensitivity) [59]. However, the psychosomatic view of CI has diminished over time due in part to a greater understanding of the roles of gene-environment interactions, oxidative stress processes, olfactory and sensory pathways, and systemic inflammation in CI [60][61][62][63]. In addition to avoiding symptom triggers, other treatment options have been identified, and while evidence-based treatments are not yet available, multidisciplinary integrative care models have been suggested [64][65][66][67][68].…”

Section: Discussionmentioning

confidence: 99%

Chemical Intolerance and Mast Cell Activation: A Suspicious Synchronicity

Palmer,

Dempsey,

Afrin

2023

JoX

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Background: Chemical Intolerance (CI) is characterized by intolerances for chemicals, foods, and drugs with multi-system symptoms. As yet, the biomechanism remains unclear. One study reported converging lines of evidence supporting a substantive association between mast cell activation syndrome (MCAS) and CI. The purpose of this study is to (1) confirm a previous report demonstrating that 60% of MCAS patients report CI and (2) examine the parallels between symptoms and intolerances in CI and MCAS. Methods: Five hundred forty-four MCAS patients were assigned a clinical MCAS score using a validated assessment instrument and were assessed for CI using the validated Quick Environmental Exposure Sensitivity Index. Results: Our outcomes confirm the previously published study where the majority of MCAS patients also have CI. There was a clear overlap between various ICD-10 diagnostic categories and CI symptoms, providing further support for a potential shared mechanism. Conclusions: Exposures to pesticides, volatile organic compounds, combustion products, and mold have previously been reported as initiators of CI. However, until recently, little was known about the biological mechanism involved that could explain the multisystem symptoms associated with CI. This paper addresses a newly identified biomechanism for disease, which may underlie a host of “medically unexplained symptoms” triggered by xenobiotics.

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“…Specifically, there has been a significant relationship with the Superoxide Dismutase 2 (SOD2) [ 2 ]. Another study found that PON1 polymorphisms may play an additional role in patients with MCS who also have anxiety and depression [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Multiple Chemical Sensitivity Syndrome: First Symptoms and Evolution of the Clinical Picture: Case-Control Study/Epidemiological Case-Control Study

Fares-Medina

Díaz-Caro

García-Montes

et al. 2022

IJERPH

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Multiple chemical sensitivity (MCS) is a chronic condition characterized by the appearance of symptoms caused by exposure to chemical compounds that are tolerable for the general population. It mainly affects middle-aged women. There are very few studies focusing on the most frequent symptoms of MCS considering age groups and gender. The main goal of this study was to find the most frequent symptoms both at the onset of the disease and at the present time describing them by age groups. The QEESI (Quick Environmental Exposure and Sensitivity Inventory) questionnaire, Scale 3 which assesses symptoms and their severity, was used as a diagnostic tool for the disease. A case-control study was conducted with the participation of 210 people. Of the cases, 94.3% were women. The symptoms that most often manifested first were airway and mucous membrane alterations (68.9%). In the development of the disease, we found cognitive alterations (OR = 31.25), heart or chest problems (OR = 22.49), neuromuscular problems (OR = 20.00) and head-related symptomatology (OR = 19.29). Identifying the most frequent pattern of symptoms by age group and sex will allow an early diagnosis of the disease to improve its prognosis and treatment.

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PON1 Polymorphisms Can Predict Generalized Anxiety and Depressed Mood in Patients with Multiple Chemical Sensitivity

Cited by 4 publications

References 109 publications

Oxidative Stress Markers and Antioxidant Enzymes in Children and Adolescents with Depressive Disorder and Impact of Omega-3 Fatty Acids in Randomised Clinical Trial

Oxidative Stress Markers and Antioxidant Enzymes in Children and Adolescents with Depressive Disorder and Impact of Omega-3 Fatty Acids in Randomised Clinical Trial

Chemical Intolerance and Mast Cell Activation: A Suspicious Synchronicity

Multiple Chemical Sensitivity Syndrome: First Symptoms and Evolution of the Clinical Picture: Case-Control Study/Epidemiological Case-Control Study

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