PON-1 haplotype (-108C&gt;T, L55M, and Q192R) modulates the serum levels and activity PONase promoting an atherogenic lipid profile in rheumatoid arthritis patients

Zaragoza-García, Óscar; Guzmán‐Guzmán, Iris Paola; Moreno‐Godínez, Ma. Elena; Navarro‐Zarza, José Eduardo; Antonio-Véjar, Verónica; Ramı́rez, Mónica; Parra‐Rojas, Isela

doi:10.1007/s10067-020-05218-w

Cited by 7 publications

(6 citation statements)

References 64 publications

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“…With the increase in disease degree, the semiquantitative scores of MSUS in different groups would increase, indicating that the consistency between diagnosis of MSUS and disease degree was good. The degree of illness in elderly patients with RA was positively correlated with parameters of MSUS ( r = 0.886, P < 0.001), which was consistent with the results of Zaragoza-García Oscar et al [ 19 ]. At the same time, Naqvi Atta Abbas et al [ 20 ] showed that the DAS28 score was used to evaluate the condition of patients diagnosed with RA, and the analysis found that the semiquantitative score of MSUS increased significantly with the increase of the disease severity of RA, suggesting that the semiquantitative score of MSUS can determine the condition of RA.…”

Section: Discussionsupporting

confidence: 91%

Relationship between the Degree of Illness in Elderly Patients with Rheumatoid Arthritis and Parameters of Musculoskeletal Ultrasound and Oswestry Dysfunction Index and Clinical Value Analysis

Shen

Shan

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. The aim of the study is to explore the relationship between the degree of illness in elderly patients with rheumatoid arthritis (RA) and parameters of musculoskeletal ultrasound (MSUS) and Oswestry Dysfunction Index (ODI) and its clinical value. Methods. The clinical data of 100 elderly patients with RA admitted to our hospital from May 2016 to May 2022 were retrospectively analyzed. The patients were divided into four groups, including the remission group (DAS28 ≤ 2.6, n = 25), low activity group (2.6 ≤ DAS28 ≤ 3.2, n = 25), middle activity group (3.2 ≤ DAS28 ≤ 5.1, n = 25), and high activity group (DAS > 5.1, n = 25) according to the disease activity score-28 (DAS28). All patients underwent ultrasonic detection to compare the relationship between the degree of illness in elderly patients with RA and parameters of MSUS and ODI. Results. The total semiquantitative score of MSUS and ODI score in the remission group were obviously lower than those in the other three groups ( P < 0.001 ). The degree of illness in elderly patients with RA was positively correlated with parameters of MSUS (r = 0.886, P < 0.001 ). The degree of illness in elderly patients with RA was positively correlated with ODI (r = 0.907, P < 0.001 ). Conclusion. The degree of illness in elderly patients with RA is closely related to parameters of MSUS and ODI, and the parameters of MSUS have a higher evaluation value for the degree of illness in elderly patients with RA, which are correlated with ODI.

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Section: Discussionsupporting

confidence: 91%

Relationship between the Degree of Illness in Elderly Patients with Rheumatoid Arthritis and Parameters of Musculoskeletal Ultrasound and Oswestry Dysfunction Index and Clinical Value Analysis

Shen

Shan

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Different mechanisms have been suggested to explicate the impairment of PON-1 activity in RA patients, including the enhanced generation of reactive oxygen species [ 39 ] compositional changes of HDL [ 23 ], inhibitory effect of proinflammatory cytokines on the liver synthesis of PON-1 [ 40 ], and genetic polymorphisms of the PON-1 gene [ 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

“…A recent meta-analysis of 12 studies reported a significant association between PON-1 polymorphisms and enzyme activity in RA [ 44 ]. A relationship between PON-1 polymorphisms, PON-1 activity, atherogenic lipid profile, and atherosclerotic plaque burden has also been reported, suggesting that the genetic regulation of PON-1 activity may contribute to the increased cardiovascular burden in RA [ 21 , 42 , 45 ]. While impaired PON-1 activity and increased concentrations of oxidized LDL have been involved in the development of ED [ 46 ] the evidence supporting this link in RA patients is currently limited.…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress Biomarkers and Peripheral Endothelial Dysfunction in Rheumatoid Arthritis: A Monocentric Cross-Sectional Case-Control Study

et al. 2020

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Previous studies have suggested that oxidative stress may heighten atherosclerotic burden in rheumatoid arthritis (RA), but direct evidence is lacking. Objective: To evaluate the relationship between established plasma oxidative stress biomarkers and peripheral endothelial dysfunction (ED), a marker of early atherosclerosis, in RA. Methods: Paroxonase-1 (PON-1), protein-SH (PSH), and malondialdehyde (MDA) were measured in 164 RA patient s and 100 age- and sex-matched healthy controls without previous cardiovascular events. Peripheral ED, evaluated by flow-mediated pulse amplitude tonometry, was defined by log-transformed reactive hyperemia index (Ln-RHI) values < 0.51. Results: PON-1 activity and PSH concentrations were significantly reduced in RA patients compared to controls. In regression analysis, increased plasma MDA levels were significantly associated with reduced Ln-RHI [B coefficient (95% CI) = −0.003 (−0.005 to −0.0008), p = 0.008] and the presence of peripheral ED (OR (95% CI) = 1.75 (1.06–2.88), p = 0.028). Contrary to our expectations, increased PON-1 activity was significantly associated, albeit weakly, with the presence of ED (OR (95% CI) = 1.00 (1.00–1.01), p = 0.017). Conclusions: In this first evidence of a link between oxidative stress and markers of atherosclerosis, MDA and PON-1 showed opposite associations with peripheral vasodilatory capacity and the presence of ED in RA. Further studies are needed to determine whether this association predicts atherosclerotic events in the RA population.

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“…Paraoxonase 1 is a calcium-dependent glycoprotein of 354 amino-acid, with a molecular weight of 43-47kDa. In humans, PON1 is encoded in the chromosome seven (7q21.3–22.1), synthesized mostly in the liver, and in small quantities in the small intestine and kidneys [ 30 , 31 ]. PON1 was first identified in mammals during the 1950s [ 32 ].…”

Section: Paraoxonase Familymentioning

confidence: 99%

Paraoxonase Role in Human Neurodegenerative Diseases

2020

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The human body has biological redox systems capable of preventing or mitigating the damage caused by increased oxidative stress throughout life. One of them are the paraoxonase (PON) enzymes. The PONs genetic cluster is made up of three members (PON1, PON2, PON3) that share a structural homology, located adjacent to chromosome seven. The most studied enzyme is PON1, which is associated with high density lipoprotein (HDL), having paraoxonase, arylesterase and lactonase activities. Due to these characteristics, the enzyme PON1 has been associated with the development of neurodegenerative diseases. Here we update the knowledge about the association of PON enzymes and their polymorphisms and the development of multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD) and Parkinson’s disease (PD).

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PON-1 haplotype (-108C>T, L55M, and Q192R) modulates the serum levels and activity PONase promoting an atherogenic lipid profile in rheumatoid arthritis patients

Cited by 7 publications

References 64 publications

Relationship between the Degree of Illness in Elderly Patients with Rheumatoid Arthritis and Parameters of Musculoskeletal Ultrasound and Oswestry Dysfunction Index and Clinical Value Analysis

Relationship between the Degree of Illness in Elderly Patients with Rheumatoid Arthritis and Parameters of Musculoskeletal Ultrasound and Oswestry Dysfunction Index and Clinical Value Analysis

Oxidative Stress Biomarkers and Peripheral Endothelial Dysfunction in Rheumatoid Arthritis: A Monocentric Cross-Sectional Case-Control Study

Paraoxonase Role in Human Neurodegenerative Diseases

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