Pomological, Sensorial, Nutritional and Nutraceutical Profile of Seven Cultivars of Cherimoya (Annona cherimola Mill)

Gentile, Carla; Mannino, Giuseppe; Palazzolo, Eristanna; Gianguzzi, Giuseppe; Perrone, Anna; Serio, Graziella; Farina, Vittorio

doi:10.3390/foods10010035

Cited by 26 publications

(30 citation statements)

References 79 publications

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“…Originally, the assay was studied with the aim to detect and quantify PACs from cranberry samples and correlate their content with potential antimicrobial activity against uropathogenic Escherichia coli [ 83 ]. However, after several experimental studies, the high reproducibility and analytical precision of BL-DMAC was demonstrated, also using different typologies of plant raw materials [ 96 , 97 , 98 , 99 , 100 , 101 , 102 ] and their derived products [ 47 , 64 , 103 , 104 , 105 ]. Since the PAC determination occurs at 640 nm, this assay is less affected by the presence of other phytochemicals, including anthocyanins [ 83 ].…”

Section: Analytical Methods For the Identification And Quantification Of Proanthocyanidinsmentioning

confidence: 99%

“… Cluster distribution of proanthocyanidins based on the total proanthocyanidin content within plant families and according to previously published data [ 96 , 97 , 99 , 100 , 101 , 102 , 104 , 105 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 ]. Euclidean distances were calculated with the average linkage method.…”

Section: Figurementioning

confidence: 99%

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Proanthocyanidins and Where to Find Them: A Meta-Analytic Approach to Investigate Their Chemistry, Biosynthesis, Distribution, and Effect on Human Health

et al. 2021

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Proanthocyanidins (PACs) are a class of polyphenolic compounds that are attracting considerable interest in the nutraceutical field due to their potential health benefits. However, knowledge about the chemistry, biosynthesis, and distribution of PACs is limited. This review summarizes the main chemical characteristics and biosynthetic pathways and the main analytical methods aimed at their identification and quantification in raw plant matrices. Furthermore, meta-analytic approaches were used to identify the main plant sources in which PACs were contained and to investigate their potential effect on human health. In particular, a cluster analysis identified PACs in 35 different plant families and 60 different plant parts normally consumed in the human diet. On the other hand, a literature search, coupled with forest plot analyses, highlighted how PACs can be actively involved in both local and systemic effects. Finally, the potential mechanisms of action through which PACs may impact human health were investigated, focusing on their systemic hypoglycemic and lipid-lowering effects and their local anti-inflammatory actions on the intestinal epithelium. Overall, this review may be considered a complete report in which chemical, biosynthetic, ecological, and pharmacological aspects of PACs are discussed.

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Section: Analytical Methods For the Identification And Quantification Of Proanthocyanidinsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Proanthocyanidins and Where to Find Them: A Meta-Analytic Approach to Investigate Their Chemistry, Biosynthesis, Distribution, and Effect on Human Health

et al. 2021

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“…A. cherimola and A. squamosa fruits are sweeter than A. muricata , A. reticulata, and A. macroprophyllata . They have a low content of lipids and proteins [ 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 ]. Furthermore, the pulp exhibits a good quantity of dietary fiber, although A. muricata and A. cherimola fruits are more fibrous.…”

Section: Agronomic Knowledgementioning

confidence: 99%

Current Situation and Perspectives of Fruit Annonaceae in Mexico: Biological and Agronomic Importance and Bioactive Properties

Fuentes

Montalvo‐González

Magaña

et al. 2021

Plants

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The Annonaceae family is one of the oldest angiosperms. The genus Annona is the one with the most species and, together with Asimina, the only ones that contain edible fruits. In the last 10 years, interest in these fruit species has increased, mainly due to their nutritional properties and their application in the treatment of human diseases. Mexico is the center of origin for most of them. However, at present much of the basic agronomic information, postharvest handling of the fruits, and their potential as new crops for areas with poor soils in organic matter or semi-dry climates is unknown. It is considered that these custard apple species may be an option to change towards instead of crops that have lost profitability and sustainability. A review of the current state of knowledge in different areas of the species A. muricata, A. macroprophyllata, A. reticulata, A. squamosa, and A. cherimola was carried out and to focus research efforts on the topics of greatest interest and on those where is required to achieve a sustainable production and use of these resources in Mexico. However, knowledge about the cultivation and potential uses of these species is needed to increase their commercialization; the integration of interdisciplinary and interinstitutional groups is required.

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“…On the other hand, the nephrotoxicity, carcinogenicity, cytotoxicity, and teratogenicity of citrinin are well known even at a very low dosage [20]. For these reasons, in the last few decades, the research of new medicinal plants as an alternative approach for the treatment of hypercholesterolemia is on-going [21][22][23]. In particular, attention is focused on the identification of new phytochemicals that may exert an antihypercholesterolemic action through a different mechanism of action from what has been reported for statins [24].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Triterpenes of Protium heptaphyllum Gum Resin Extract Display Cholesterol-Lowering Potential

Mannino

Iovino²,

Lauria

et al. 2021

IJMS

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Hypercholesterolemia is one of the major causes of cardiovascular disease, the risk of which is further increased if other forms of dyslipidemia occur. Current therapeutic strategies include changes in lifestyle coupled with drug administration. Statins represent the most common therapeutic approach, but they may be insufficient due to the onset of resistance mechanisms and side effects. Consequently, patients with mild hypercholesterolemia prefer the use of food supplements since these are perceived to be safer. Here, we investigate the phytochemical profile and cholesterol-lowering potential of Protium heptaphyllum gum resin extract (PHE). Chemical characterization via HPLC-APCI-HRMS2 and GC-FID/MS identified 13 compounds mainly belonging to ursane, oleanane, and tirucallane groups. Studies on human hepatocytes have revealed how PHE is able to reduce cholesterol production and regulate the expression of proteins involved in its metabolism. (HMGCR, PCSK9, LDLR, FXR, IDOL, and PPAR). Moreover, measuring the inhibitory activity of PHE against HMGR, moderate inhibition was recorded. Finally, molecular docking studies identified acidic tetra- and pentacyclic triterpenoids as the main compounds responsible for this action. In conclusion, our study demonstrates how PHE may be a useful alternative to contrast hypercholesterolemia, highlighting its potential as a sustainable multitarget natural extract for the nutraceutical industry that is rapidly gaining acceptance as a source of health-promoting compounds.

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Pomological, Sensorial, Nutritional and Nutraceutical Profile of Seven Cultivars of Cherimoya (Annona cherimola Mill)

Cited by 26 publications

References 79 publications

Proanthocyanidins and Where to Find Them: A Meta-Analytic Approach to Investigate Their Chemistry, Biosynthesis, Distribution, and Effect on Human Health

Proanthocyanidins and Where to Find Them: A Meta-Analytic Approach to Investigate Their Chemistry, Biosynthesis, Distribution, and Effect on Human Health

Current Situation and Perspectives of Fruit Annonaceae in Mexico: Biological and Agronomic Importance and Bioactive Properties

Bioactive Triterpenes of Protium heptaphyllum Gum Resin Extract Display Cholesterol-Lowering Potential

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