Pomolic acid reduces contractility and modulates excitation-contraction coupling in rat cardiomyocytes

López, Rubén; Bolaños, Pura; Guillen, Alis; Fernández, Marbely C; Ramos, Miguel; Granados, Sergio; Milán, Andrés F.; Caputo, Carlo; Alvarado-Castillo, Claudia; Estrada, Omar; Calderón, Juan C.

doi:10.1016/j.ejphar.2019.02.016

Cited by 5 publications

(2 citation statements)

References 35 publications

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“…PA was isolated from Eucalyptus and was also proved to have cardiovascular protective effects. In 2019, López et al (2019). demonstrated that PA has a reversible negative inotropic effect on cardiomyocytes.…”

Section: Othersmentioning

confidence: 99%

Recent progress in the development of ursolic acid derivatives as anti‐diabetes and anti‐cardiovascular agents

Dai,

Sun,

Tan

et al. 2023

Chem Biol Drug Des

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Ursolic acid (UA) is a pentacyclic triterpenoid, which exhibits many biological activities, particularly in anti‐cardiovascular and anti‐diabetes. The further application of UA is greatly limited due to its low bioavailability and poor water solubility. Up to date, various UA derivatives have been designed to overcome these shortcomings. In this paper, the authors reviewed the development of UA derivatives as the anti‐diabetes anti‐cardiovascular reagents.

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Section: Othersmentioning

confidence: 99%

Recent progress in the development of ursolic acid derivatives as anti‐diabetes and anti‐cardiovascular agents

Dai,

Sun,

Tan

et al. 2023

Chem Biol Drug Des

View full text Add to dashboard Cite

show abstract

“…A study of López et al presented that PA may also exert a positive effect on isolated cardiomyocytes from rats. PA preserved sarcoplasmic reticulum from Ca 2+ exhaustion, which enhanced the rate of cardiomyocytes relaxation (positive lusitropic effect) [93]. Further insights into the molecular mechanisms of action of PA may expand its list of cardiovascular properties.…”

Section: Pomolic Acidmentioning

confidence: 99%

Beneficial Effects of Ursolic Acid and Its Derivatives—Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions

2021

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Ursolic acid (UA) is a natural pentacyclic triterpenoid found in a number of plants such as apples, thyme, oregano, hawthorn and others. Several in vitro and in vivo studies have presented its anti-inflammatory and anti-apoptotic properties. The inhibition of NF-κB-mediated inflammatory pathways and the increased scavenging of reactive oxygen species (ROS) in numerous ways seem to be the most beneficial effects of UA. In mice and rats, administration of UA appears to slow down the development of cardiovascular diseases (CVDs), especially atherosclerosis and cardiac fibrosis. Upregulation of endothelial-type nitric oxide synthase (eNOS) and cystathionine-λ-lyase (CSE) by UA may suggest its vasorelaxant property. Inhibition of metalloproteinases activity by UA may contribute to better outcomes in aneurysms management. UA influence on lipid and glucose metabolism remains inconsistent, and additional studies are essential to verify its efficacy. Furthermore, UA derivatives appear to have a beneficial impact on the cardiovascular system. This review aims to summarize recent findings on beneficial effects of UA that may make it a promising candidate for clinical trials for the management of CVDs.

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Pentacyclic triterpenes, potential novel therapeutic approaches for cardiovascular diseases

Peng,

Wang,

Shi

et al. 2024

Arch. Pharm. Res.

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Pomolic acid reduces contractility and modulates excitation-contraction coupling in rat cardiomyocytes

Cited by 5 publications

References 35 publications

Recent progress in the development of ursolic acid derivatives as anti‐diabetes and anti‐cardiovascular agents

Recent progress in the development of ursolic acid derivatives as anti‐diabetes and anti‐cardiovascular agents

Beneficial Effects of Ursolic Acid and Its Derivatives—Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions

Pentacyclic triterpenes, potential novel therapeutic approaches for cardiovascular diseases

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