Pomegranate Peel Extract Reduces Cisplatin-Induced Toxicity and Oxidative Stress in Primary Neuron Culture

Çınar, İrfan; Yayla, Muhammed; Demirbağ, Çağlar; Binnetoğlu, Damla

doi:10.33808/clinexphealthsci.797718

Cited by 4 publications

(5 citation statements)

References 30 publications

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“…Besides, PP (200 mg/ kg) protected against aluminum chloride-induced neurotoxicity in rat models through the reduced accumulation of aluminum together with enhancement of antioxidant effect and anti-apoptotic proteins namely Bcl-2 (Moneim, 2012). Also, PP prevented the neurotoxicity induced by cisplatin, used in cancer treatment, mainly due to its antioxidant effect, and suggestive of its beneficial inclusion in cisplatinbased chemoradiotherapy after further pharmacological and clinical studies (Cinar et al, 2021).…”

Section: Neuroprotective Effectsmentioning

confidence: 91%

Ongoing and potential novel trends of pomegranate fruit peel; a comprehensive review of its health benefits and future perspectives as nutraceutical

Fahmy

Farag

2021

Journal of Food Biochemistry

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Pomegranate is an ancient shrub, globally distributed nowadays. It has been used in the middle east as a medicinal food and traditional medicine for thousands of years.Pomegranate peel (PP) constitutes about 50% of the total fruit, however, it has been previously regarded as a waste. Recent research points to PP as a rich source of phenolics (e.g., ellagitannins, flavonoids, and anthocyanins), polysaccharides, in addition to its biotransformed metabolites viz. urolithins making it a valuable waste with promising pharmacological actions.Compared to the pulp and the juice, PP exhibited stronger antioxidant and antimicrobial activities. Besides, it inhibited inflammation in several conditions, including colitis, arthritis, hepatitis, contact dermatitis, and lung inflammation. Moreover, it displayed anti-osteoporosis, anti-hyperglycemic, antidiabetic, antihypertensive, vasculoprotective, hepatoprotective, neuroprotective, and immunomodulatory effects. Additionally, it was effective as a prebiotic and in obesity control, besides it promoted wound healing. Furthermore, PP demonstrated anticancer effects against different cancer types, for example, colon, liver, thyroid, uterine, breast, bladder, prostate, leukemia, and osteosarcoma. Despite PP safety, it may interfere with the metabolism of other drugs because it inhibits cytochromes (CYP) changing their bioavailability, effectiveness, and toxicity. PP biowaste valorization not only avoids against its environmental and economic burden but can also provide a promising platform to produce novel or improved nutraceuticals. This study provides a comprehensive overview of PP biological activities with the reported action mechanisms related to its phytochemicals and further biotransformed metabolites inside the body. Future research prospects to unravel the merits of such waste and optimize its use are discussed.Practical application: Pomegranate is widely distributed throughout the world.Although its peel was previously considered a waste, recent research regards it as a rich source of bioactive compounds with promising biological activities. Its recycling not only overcomes the bio-waste problems, but also provides a source of valuable compounds with several health benefits.

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Section: Neuroprotective Effectsmentioning

confidence: 91%

Ongoing and potential novel trends of pomegranate fruit peel; a comprehensive review of its health benefits and future perspectives as nutraceutical

Fahmy

Farag

2021

Journal of Food Biochemistry

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“…The most abundant ET is PUN, which exists as alpha and beta isomers in nearly equal proportions. Upon hydrolysis, one PUN molecule gives a total of three EA molecules, via the intermediates punicalin and gallagic acid [17][18][19] (Figure 2).…”

Section: Of 21mentioning

confidence: 99%

“…The most abundant ET is PUN, which exists as alpha and beta isomers in nearly e proportions. Upon hydrolysis, one PUN molecule gives a total of three EA molecules the intermediates punicalin and gallagic acid [17][18][19] (Figure 2). EA (2,3,7,8-tetrahydroxy-chromeno [5,4,3-cde]chromene-5,10-dione) is the agly component of the ellagitanins-a group of the hydrolyzable tannins [10].…”

Section: Of 21mentioning

confidence: 99%

Preventive and Therapeutic Effects of Punica granatum L. Polyphenols in Neurological Conditions

Aleksandrova

Alexova

Dragomanova

et al. 2023

IJMS

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Pomegranate (Punica granatum L.) is a polyphenol-rich food and medicinal plant containing flavonols, anthocyanins, and tannins. Ellagitannins (ETs) are the most abundant polyphenols in pomegranate. A growing body of research shows that polyphenol-rich pomegranate extracts and their metabolites target multiple types of brain cell and support their redox balance, proliferation and survival, as well as cell signaling. Independent studies have demonstrated that the significant neuroprotective effects of ETs are mediated by their antioxidant and anti-inflammatory effects, their chelating properties, by their ability to activate various signaling pathways, as well as the ability to influence mitochondrial damage, thus regulating autophagy, apoptosis and neurotransmitter signaling. The multitude of in vitro and in vivo studies summarized in the present review suggest that pomegranate polyphenols act on both neuronal and glial cells directly, and also affect blood–brain barrier function, restoring redox balance in the blood and brain and increasing blood flow to the brain.

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“…So far, different types of biological activities such as antimutagenic, antiproliferative, anti-inflammatory, and chemo-preventive properties were stated for pomegranate peel extract (PPE) according to chemical composition (El-Kady et al, 2021;Mastrogiovanni et al, 2019;Viswanath et al, 2019). Furthermore, low toxicity and high safety have been reported by means of in vivo and in vitro studies (Cinar et al, 2021;Hasnaoui, 2022;Mastrogiovanni et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…So far, different types of biological activities such as antimutagenic, antiproliferative, anti‐inflammatory, and chemo‐preventive properties were stated for pomegranate peel extract (PPE) according to chemical composition (El‐Kady et al, 2021 ; Mastrogiovanni et al, 2019 ; Viswanath et al, 2019 ). Furthermore, low toxicity and high safety have been reported by means of in vivo and in vitro studies (Cinar et al, 2021 ; Hasnaoui, 2022 ; Mastrogiovanni et al, 2019 ). Therefore, it seems that PPE has enough potential for shelf life enhancement in food products (Belgacem et al, 2021 ; Kumar et al, 2022 , 2023 ) and also in formulation of functional foods and nutraceutical supplements (Moussaoui et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Ultrasonication/dynamic maceration‐assisted extraction method as a novel combined approach for recovery of phenolic compounds from pomegranate peel

Andishmand,

Masoumi,

Torbati

et al. 2023

Food Science & Nutrition

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According to recent studies, pomegranate peel (PP) has the potential to be inverted from environmental pollutant waste to wealth due to possessing valuable phenolic compounds at a higher amount compared to edible parts. So far, different types of biological activities such as antimutagenic, antiproliferative, anti‐inflammatory, and chemo‐preventive properties were stated for pomegranate peel extract (PPE) according to chemical composition. In the present research, the probable intensifying effects of two extraction methods and optimum conditions for novel combined method of ultrasonication and dynamic maceration‐assisted extraction of PPE using response surface methodology (RSM) were determined. A Box–Behnken Design (BBD) was employed to optimize three extraction variables, including sonication time (X1), sonication temperature (X2), and stirring speed (X3) for the achievement of high extraction yield of the phenolic compounds and antioxidant activity. The optimized conditions to obtain maximum extraction efficiency were determined as X1 = 70 min, X2 = 61.8°C, and X3 = 1000 rpm. The experimental values were in line with the values anticipated by RSM models, which indicates the appropriateness of the applied quadratic model and the accomplishment of RSM in optimizing the extraction conditions. The results suggest that the extraction of PPE by mix of ultrasonication as a modern method and dynamic maceration as a conventional method could improve its bioactive extractability and the obtained values were higher than any of the methods used. In other words, these two methods together have intensifying effects in increasing extraction efficiency which could further be utilized in food and agricultural industry.

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Pomegranate Peel Extract Reduces Cisplatin-Induced Toxicity and Oxidative Stress in Primary Neuron Culture

Cited by 4 publications

References 30 publications

Ongoing and potential novel trends of pomegranate fruit peel; a comprehensive review of its health benefits and future perspectives as nutraceutical

Ongoing and potential novel trends of pomegranate fruit peel; a comprehensive review of its health benefits and future perspectives as nutraceutical

Preventive and Therapeutic Effects of Punica granatum L. Polyphenols in Neurological Conditions

Ultrasonication/dynamic maceration‐assisted extraction method as a novel combined approach for recovery of phenolic compounds from pomegranate peel

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