Pomegranate peel as a phytogenic in broiler chickens: Influence upon antioxidant, lipogenesis and hypotensive response

Abstract

The aim of this study was to evaluate antioxidant, antihyperlipidemic and hypotensive properties of pomegranate peel (PP) on antioxidant status, fat deposition, lipid peroxidation and pulmonary hypertensive response in broiler chickens. A total of 375 one‐day‐old male broilers (Cobb 500) were randomly assigned to five treatments included dietary PP levels of 0, 2.5, 5.0, 7.5 and 10 g/kg. Supplementation of PP at 7.5 and 10 g/kg resulted in significant upregulation of hepatic catalase (p < 0.004) and superoxide dismutase1 (SOD1; p < 0.05), which reflected in decreased concentration of circulatory malondialdehyde (MDA). Dietary inclusion of PP at 7.5 and 1.0 g/kg significantly decreased serum concentrations of triglycerides (p < 0.004) and cholesterol (p < 0.006) with concomitant decrease in abdominal fat deposition (p < 0.05). The antihyperlipidemic effect of PP was mediated through down‐regulation of peroxisome proliferator activated receptor alpha (PPARα). Hypotensive effect of PP was also observed at 7.5 and 10 g/kg as reduced heart weight and the right‐to‐total ventricular weight ratio (RV/TV) and decreased mortality from pulmonary hypertension. The hypotensive property of PP was associated with increased concentration of serum nitric oxide. In conclusion, this study revealed antioxidative, antihyperlipidemic and hypotensive effects of PP at 7.5 and 10 g/kg in broiler chickens exposed to hypobaric hypoxia. Health‐beneficial effects of PP suggest this product as a promising multi‐functional phytogenic feed additive for broiler chickens.

Effects of dietary supplementation with quercetagetin on nutrient digestibility, intestinal morphology, immunity, and antioxidant capacity of broilers

“…Normally, fewer free radicals are produced of poultry, which can be timely eliminated by the antioxidant system to prevent oxidative stress and injury (1). However, with the increase in poultry production scale and intensity, various factors, such as excessive feeding, lower feeding management, unstable feed quality (excessive metal element content, mycotoxin pollution, and lipid oxidation), and pathogen infestation increase the free radical production in poultry through the respiratory burst mechanism, which exceeds the scavenging capacity of the antioxidant system, triggering a free radical chain reaction, which leads to oxidative stress, and damage (2)(3)(4)(5)(6)(7). In chicks, oxidative stress also reduces disease resistance, survival rate, feed return, and production performance and causes maldevelopment.…”

Managing broiler production challenges at high altitude

“…Pomegranate is a rich source of flavonoids, with the peel containing the highest flavonoid content and greatest antioxidant capacity compared to the seed and juice (Rafiei and Khajali, 2021). Feeding broiler chickens with pomegranate peel at 7.5 and 10 g/kg effectively subsided right ventricular hypertrophy and decreased ascites mortality (Ahmadipour et al., 2021). Inclusion of 5 g/kg garlic bulb in diets effectively reduced ascites incidence in broiler chickens (Varmaghany et al., 2015).…”

Pomegranate Peel in the Amelioration of High-Altitude Disease: A Network Pharmacology and Molecular Docking Study of Underlying Mechanisms

“…Numerous biological activities have been attributed to PP, such as antioxidant, antitumor, anti-infammatory, neuroprotective, antiviral, and antibacterial efects [3]. Ahmadipour et al found that PP reduced pulmonary hypertension and blood pressure in broiler chickens due to its antioxidant and hypolipidemic efects [4] and it was also shown to reduce serum malondialdehyde in broilers [5]. Te phenolic and favonoid compounds present in PP scavenged reactive oxygen species to produce antihyperglycemic and antihyperlipidemic actions.…”